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Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer.

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Title: Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer.
Authors: Mueller, Sarina Katrin (AUTHOR), Mantsopoulos, Konstantinos (AUTHOR), Semrau, Sabine (AUTHOR), Agaimy, Abbas (AUTHOR), Eckstein, Markus (AUTHOR), Traxdorf, Maximilian (AUTHOR), Gostian, Antoniu Oreste (AUTHOR), Goncalves, Miguel (AUTHOR), Sievert, Matti (AUTHOR), Haderlein, Marlen (AUTHOR), Grundtner, Philipp (AUTHOR), Hecht, Markus (AUTHOR), Koch, Michael (AUTHOR), Fietkau, Rainer (AUTHOR), Iro, Heinrich (AUTHOR), Scherl, Claudia (AUTHOR)
Source: Acta Oto-Laryngologica. Feb2021, Vol. 141 Issue 2, p187-192. 6p.
Subjects: Neck radiography, Tumor suppressor genes, Adjuvant treatment of cancer, Computed tomography, Immunohistochemistry, Neck surgery, Papillomaviruses, Probability theory, Ultrasonic imaging, Treatment effectiveness, Retrospective studies, Descriptive statistics, Oropharyngeal cancer, Chemoradiotherapy
Abstract: Human papillomavirus (HPV)+ and HPV– oropharyngeal squamous cell carcinomas (OPSCC) are separate tumor entities. The aim of this study was to examine if the p16 status influences the need and outcome of a salvage neck dissection (SND) after primary radiochemotherapy (pRCT). Retrospective study of 164 patients (n = 108 p16–, n = 56 p16+) who underwent pRCT for OPSCC between 2009 and 2016. HPV status was defined via p16 immunohistochemical staining. Clinical nodal status was assessed using ultrasound and computed tomography of the neck with contrast. Of the 56 p16+ patients, 17 (30.4%) patients were given an indication for a SND after pRCT with 4 (23.5%) patients showing persistent malignant nodes. Of the 108 p16– patients, 24 (22.2%) patients underwent a SND with 8 (33.3%) patients showing persistent malignant nodes. There was no significant association of the p16 status and neither the indication for SND (p(Chi2(two-sided)-Test) = 0.25, ϕ = 0.34) nor the occurrence of positive nodes (p(Chi2(two-sided)-Test) = 0.74, ϕ = 0.50). The probability for persistence of the ypN + nodal status independent of HPV-status was 29.2%(12/41). There was neither a significant association between the p16 status and the indication for a SND nor for persistent malignant nodal disease after pRCT. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer.
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  Data: <searchLink fieldCode="AR" term="%22Mueller%2C+Sarina+Katrin%22">Mueller, Sarina Katrin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mantsopoulos%2C+Konstantinos%22">Mantsopoulos, Konstantinos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Semrau%2C+Sabine%22">Semrau, Sabine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Agaimy%2C+Abbas%22">Agaimy, Abbas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eckstein%2C+Markus%22">Eckstein, Markus</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Traxdorf%2C+Maximilian%22">Traxdorf, Maximilian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gostian%2C+Antoniu+Oreste%22">Gostian, Antoniu Oreste</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goncalves%2C+Miguel%22">Goncalves, Miguel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sievert%2C+Matti%22">Sievert, Matti</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haderlein%2C+Marlen%22">Haderlein, Marlen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grundtner%2C+Philipp%22">Grundtner, Philipp</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hecht%2C+Markus%22">Hecht, Markus</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koch%2C+Michael%22">Koch, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fietkau%2C+Rainer%22">Fietkau, Rainer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iro%2C+Heinrich%22">Iro, Heinrich</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scherl%2C+Claudia%22">Scherl, Claudia</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Feb2021, Vol. 141 Issue 2, p187-192. 6p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Neck+radiography%22">Neck radiography</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+suppressor+genes%22">Tumor suppressor genes</searchLink><br /><searchLink fieldCode="DE" term="%22Adjuvant+treatment+of+cancer%22">Adjuvant treatment of cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Immunohistochemistry%22">Immunohistochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Neck+surgery%22">Neck surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Papillomaviruses%22">Papillomaviruses</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Ultrasonic+imaging%22">Ultrasonic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Oropharyngeal+cancer%22">Oropharyngeal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Chemoradiotherapy%22">Chemoradiotherapy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Human papillomavirus (HPV)+ and HPV– oropharyngeal squamous cell carcinomas (OPSCC) are separate tumor entities. The aim of this study was to examine if the p16 status influences the need and outcome of a salvage neck dissection (SND) after primary radiochemotherapy (pRCT). Retrospective study of 164 patients (n = 108 p16–, n = 56 p16+) who underwent pRCT for OPSCC between 2009 and 2016. HPV status was defined via p16 immunohistochemical staining. Clinical nodal status was assessed using ultrasound and computed tomography of the neck with contrast. Of the 56 p16+ patients, 17 (30.4%) patients were given an indication for a SND after pRCT with 4 (23.5%) patients showing persistent malignant nodes. Of the 108 p16– patients, 24 (22.2%) patients underwent a SND with 8 (33.3%) patients showing persistent malignant nodes. There was no significant association of the p16 status and neither the indication for SND (p(Chi2(two-sided)-Test) = 0.25, ϕ = 0.34) nor the occurrence of positive nodes (p(Chi2(two-sided)-Test) = 0.74, ϕ = 0.50). The probability for persistence of the ypN + nodal status independent of HPV-status was 29.2%(12/41). There was neither a significant association between the p16 status and the indication for a SND nor for persistent malignant nodal disease after pRCT. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2020.1831697
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 187
    Subjects:
      – SubjectFull: Neck radiography
        Type: general
      – SubjectFull: Tumor suppressor genes
        Type: general
      – SubjectFull: Adjuvant treatment of cancer
        Type: general
      – SubjectFull: Computed tomography
        Type: general
      – SubjectFull: Immunohistochemistry
        Type: general
      – SubjectFull: Neck surgery
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      – SubjectFull: Papillomaviruses
        Type: general
      – SubjectFull: Probability theory
        Type: general
      – SubjectFull: Ultrasonic imaging
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Oropharyngeal cancer
        Type: general
      – SubjectFull: Chemoradiotherapy
        Type: general
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      – TitleFull: Influence of p16 status on indication and outcome of salvage neck dissection in oropharyngeal cancer.
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