Bibliographic Details
| Title: |
Efficacy and Safety of Metformin for Obesity: A Systematic Review. |
| Authors: |
Masarwa, Reem, Brunetti, Vanessa C., Aloe, Stephanie, Henderson, Mélanie, Platt, Robert W., Filion, Kristian B. |
| Source: |
Pediatrics. Mar2021, Vol. 147 Issue 3, p1-15. 15p. |
| Subjects: |
Drug efficacy, Safety, Online information services, Lifestyles, Homeostasis, Medical information storage & retrieval systems, Medical databases, Information storage & retrieval systems, Childhood obesity, Systematic reviews, Gastrointestinal diseases, Treatment effectiveness, Descriptive statistics, Metformin, MEDLINE, Body mass index, Insulin resistance, Evaluation |
| Abstract: |
CONTEXT: The efficacy and safety of metformin for obesity in children and adolescents remains unclear. OBJECTIVE: To assess the efficacy and safety of metformin via systematic review. DATA SOURCES: Data sources included PubMed, Embase, the Cochrane Library, Scopus, and ClincalTrials.gov (inception to November 2019). STUDY SELECTION: We selected randomized controlled trials (RCTs) in which researchers assessed the efficacy and safety of metformin with lifestyle interventions, compared with a placebo with lifestyle interventions, in children and adolescents with obesity. DATA EXTRACTION: Two researchers independently extracted data and assessed quality. The primary outcomes were mean changes from baseline in BMI, BMI z score, homeostatic model assessment of insulin resistance, and gastrointestinal adverse effects. RESULTS:Twenty-four RCTs (1623 patients; range: 16 to 151) were included. Ages ranged from 4 to 19 years, and follow-up ranged from 2 months to 2 years. Metformin resulted in a modest decrease in BMI (range of mean values: 22.70 to 1.30 vs 21.12 to 1.90), BMI z score (range of mean values: 20.37 to 20.03 vs 20.22 to 0.15), and homeostatic model assessment of insulin resistance (range of mean values: 23.74 to 1.00 vs 21.40 to 2.66). Metformin resulted in a higher frequency of gastrointestinal adverse effects (range: 2% to 74% vs 0% to 42%). LIMITATIONS: The available evidence is of varying quality, with high heterogeneity between trials, suggesting some uncertainty in the benefits of metformin in this population. CONCLUSIONS: With this systematic review of RCTs, we suggest that metformin has modest but favorable effects on weight and insulin resistance and a tolerable safety profile among children and adolescents with obesity. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
