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The ubiquitin E3 ligase Nedd4‐2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.

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Title: The ubiquitin E3 ligase Nedd4‐2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
Authors: Wang, Shenglan (AUTHOR), Qi, Simin (AUTHOR), Kogure, Yoko (AUTHOR), Kanda, Hirosato (AUTHOR), Tian, Lin (AUTHOR), Yamamoto, Satoshi (AUTHOR), Noguchi, Koichi (AUTHOR), Dai, Yi (AUTHOR)
Source: European Journal of Neuroscience. Mar2021, Vol. 53 Issue 6, p1691-1704. 14p. 1 Chart, 4 Graphs.
Subjects: Ubiquitin ligases, Ubiquitination, Dorsal root ganglia, Allodynia, Sensory neurons
Abstract: Neural precursor cell‐expressed developmentally downregulated protein 4‐2 (Nedd4‐2) is a member of the E3 ubiquitin ligase family that is highly expressed in sensory neurons and involved in pain modulation via downregulation of ion channels in excitable membranes. Ubiquitination involving Nedd4‐2 is regulated by adenosine monophosphate‐activated protein kinase (AMPK), which is impaired in the dorsal root ganglion (DRG) neurons of db/db mice. AMPK negatively regulates the expression of transient receptor potential ankyrin 1 (TRPA1), a recognised pain sensor expressed on the membrane of DRG neurons, consequently relieving mechanical allodynia in db/db mice. Herein, we studied the involvement of Nedd4‐2 in painful diabetic neuropathy and observed that Nedd4‐2 negatively regulated diabetic mechanical allodynia. Nedd4‐2 was co‐expressed with TRPA1 in mouse DRG neurons. Nedd4‐2 was involved in TRPA1 ubiquitination, this ubiquitination, as well as Nedd4‐2–TRPA1 interaction, was decreased in db/db mice. Moreover, Nedd4‐2 levels were decreased in db/db mice, while an abnormal intracellular distribution was observed in short‐term high glucose‐cultured DRG neurons. AMPK activators not only restored Nedd4‐2 distribution but also increased Nedd4‐2 expression. These findings demonstrate that Nedd4‐2 is a potent regulator of TRPA1 and that the abnormal expression of Nedd4‐2 in DRG neurons contributes to diabetic neuropathic pain. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: The ubiquitin E3 ligase Nedd4‐2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Shenglan%22">Wang, Shenglan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qi%2C+Simin%22">Qi, Simin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kogure%2C+Yoko%22">Kogure, Yoko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kanda%2C+Hirosato%22">Kanda, Hirosato</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Lin%22">Tian, Lin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yamamoto%2C+Satoshi%22">Yamamoto, Satoshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Noguchi%2C+Koichi%22">Noguchi, Koichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dai%2C+Yi%22">Dai, Yi</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2021, Vol. 53 Issue 6, p1691-1704. 14p. 1 Chart, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ubiquitin+ligases%22">Ubiquitin ligases</searchLink><br /><searchLink fieldCode="DE" term="%22Ubiquitination%22">Ubiquitination</searchLink><br /><searchLink fieldCode="DE" term="%22Dorsal+root+ganglia%22">Dorsal root ganglia</searchLink><br /><searchLink fieldCode="DE" term="%22Allodynia%22">Allodynia</searchLink><br /><searchLink fieldCode="DE" term="%22Sensory+neurons%22">Sensory neurons</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Neural precursor cell‐expressed developmentally downregulated protein 4‐2 (Nedd4‐2) is a member of the E3 ubiquitin ligase family that is highly expressed in sensory neurons and involved in pain modulation via downregulation of ion channels in excitable membranes. Ubiquitination involving Nedd4‐2 is regulated by adenosine monophosphate‐activated protein kinase (AMPK), which is impaired in the dorsal root ganglion (DRG) neurons of db/db mice. AMPK negatively regulates the expression of transient receptor potential ankyrin 1 (TRPA1), a recognised pain sensor expressed on the membrane of DRG neurons, consequently relieving mechanical allodynia in db/db mice. Herein, we studied the involvement of Nedd4‐2 in painful diabetic neuropathy and observed that Nedd4‐2 negatively regulated diabetic mechanical allodynia. Nedd4‐2 was co‐expressed with TRPA1 in mouse DRG neurons. Nedd4‐2 was involved in TRPA1 ubiquitination, this ubiquitination, as well as Nedd4‐2–TRPA1 interaction, was decreased in db/db mice. Moreover, Nedd4‐2 levels were decreased in db/db mice, while an abnormal intracellular distribution was observed in short‐term high glucose‐cultured DRG neurons. AMPK activators not only restored Nedd4‐2 distribution but also increased Nedd4‐2 expression. These findings demonstrate that Nedd4‐2 is a potent regulator of TRPA1 and that the abnormal expression of Nedd4‐2 in DRG neurons contributes to diabetic neuropathic pain. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.15062
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        Text: English
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      – SubjectFull: Ubiquitination
        Type: general
      – SubjectFull: Dorsal root ganglia
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      – SubjectFull: Allodynia
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      – SubjectFull: Sensory neurons
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      – TitleFull: The ubiquitin E3 ligase Nedd4‐2 relieves mechanical allodynia through the ubiquitination of TRPA1 channel in db/db mice.
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            NameFull: Wang, Shenglan
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              Text: Mar2021
              Type: published
              Y: 2021
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