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Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up.

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Title: Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up.
Authors: Gamberini, Lorenzo, Mazzoli, Carlo Alberto, Sintonen, Harri, Colombo, Davide, Scaramuzzo, Gaetano, Allegri, Davide, Tonetti, Tommaso, Zani, Gianluca, Capozzi, Chiara, Giampalma, Emanuela, Agnoletti, Vanni, Becherucci, Filippo, Bertellini, Elisabetta, Castelli, Andrea, Cappellini, Iacopo, Cavalli, Irene, Crimaldi, Federico, Damiani, Federica, Fusari, Maurizio, Gordini, Giovanni
Source: Quality of Life Research. Oct2021, Vol. 30 Issue 10, p2805-2817. 13p. 1 Diagram, 3 Charts, 1 Graph.
Subjects: Coronavirus diseases, Critical care medicine, Adult respiratory distress syndrome, Quality of life, Artificial respiration
Abstract: Purpose: The onset of the coronavirus disease 19 (COVID-19) pandemic in Italy induced a dramatic increase in the need for intensive care unit (ICU) beds for a large proportion of patients affected by COVID-19-related acute respiratory distress syndrome (ARDS). The aim of the present study was to describe the health-related quality of life (HRQoL) at 90 days after ICU discharge in a cohort of COVID-19 patients undergoing invasive mechanical ventilation and to compare it with an age and sex-matched sample from the general Italian and Finnish populations. Moreover, the possible associations between clinical, demographic, social factors, and HRQoL were investigated. Methods: COVID-19 ARDS survivors from 16 participating ICUs were followed up until 90 days after ICU discharge and the HRQoL was evaluated with the 15D instrument. A parallel cohort of age and sex-matched Italian population from the same geographic areas was interviewed and a third group of matched Finnish population was extracted from the Finnish 2011 National Health survey. A linear regression analysis was performed to evaluate potential associations between the evaluated factors and HRQoL. Results: 205 patients answered to the questionnaire. HRQoL of the COVID-19 ARDS patients was significantly lower than the matched populations in both physical and mental dimensions. Age, sex, number of comorbidities, ARDS class, duration of invasive mechanical ventilation, and occupational status were found to be significant determinants of the 90 days HRQoL. Clinical severity at ICU admission was poorly correlated to HRQoL. Conclusion: COVID-19-related ARDS survivors at 90 days after ICU discharge present a significant reduction both on physical and psychological dimensions of HRQoL measured with the 15D instrument. Trial Registration: NCT04411459. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up.
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  Data: <searchLink fieldCode="AR" term="%22Gamberini%2C+Lorenzo%22">Gamberini, Lorenzo</searchLink><br /><searchLink fieldCode="AR" term="%22Mazzoli%2C+Carlo+Alberto%22">Mazzoli, Carlo Alberto</searchLink><br /><searchLink fieldCode="AR" term="%22Sintonen%2C+Harri%22">Sintonen, Harri</searchLink><br /><searchLink fieldCode="AR" term="%22Colombo%2C+Davide%22">Colombo, Davide</searchLink><br /><searchLink fieldCode="AR" term="%22Scaramuzzo%2C+Gaetano%22">Scaramuzzo, Gaetano</searchLink><br /><searchLink fieldCode="AR" term="%22Allegri%2C+Davide%22">Allegri, Davide</searchLink><br /><searchLink fieldCode="AR" term="%22Tonetti%2C+Tommaso%22">Tonetti, Tommaso</searchLink><br /><searchLink fieldCode="AR" term="%22Zani%2C+Gianluca%22">Zani, Gianluca</searchLink><br /><searchLink fieldCode="AR" term="%22Capozzi%2C+Chiara%22">Capozzi, Chiara</searchLink><br /><searchLink fieldCode="AR" term="%22Giampalma%2C+Emanuela%22">Giampalma, Emanuela</searchLink><br /><searchLink fieldCode="AR" term="%22Agnoletti%2C+Vanni%22">Agnoletti, Vanni</searchLink><br /><searchLink fieldCode="AR" term="%22Becherucci%2C+Filippo%22">Becherucci, Filippo</searchLink><br /><searchLink fieldCode="AR" term="%22Bertellini%2C+Elisabetta%22">Bertellini, Elisabetta</searchLink><br /><searchLink fieldCode="AR" term="%22Castelli%2C+Andrea%22">Castelli, Andrea</searchLink><br /><searchLink fieldCode="AR" term="%22Cappellini%2C+Iacopo%22">Cappellini, Iacopo</searchLink><br /><searchLink fieldCode="AR" term="%22Cavalli%2C+Irene%22">Cavalli, Irene</searchLink><br /><searchLink fieldCode="AR" term="%22Crimaldi%2C+Federico%22">Crimaldi, Federico</searchLink><br /><searchLink fieldCode="AR" term="%22Damiani%2C+Federica%22">Damiani, Federica</searchLink><br /><searchLink fieldCode="AR" term="%22Fusari%2C+Maurizio%22">Fusari, Maurizio</searchLink><br /><searchLink fieldCode="AR" term="%22Gordini%2C+Giovanni%22">Gordini, Giovanni</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Oct2021, Vol. 30 Issue 10, p2805-2817. 13p. 1 Diagram, 3 Charts, 1 Graph.
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  Data: Purpose: The onset of the coronavirus disease 19 (COVID-19) pandemic in Italy induced a dramatic increase in the need for intensive care unit (ICU) beds for a large proportion of patients affected by COVID-19-related acute respiratory distress syndrome (ARDS). The aim of the present study was to describe the health-related quality of life (HRQoL) at 90 days after ICU discharge in a cohort of COVID-19 patients undergoing invasive mechanical ventilation and to compare it with an age and sex-matched sample from the general Italian and Finnish populations. Moreover, the possible associations between clinical, demographic, social factors, and HRQoL were investigated. Methods: COVID-19 ARDS survivors from 16 participating ICUs were followed up until 90 days after ICU discharge and the HRQoL was evaluated with the 15D instrument. A parallel cohort of age and sex-matched Italian population from the same geographic areas was interviewed and a third group of matched Finnish population was extracted from the Finnish 2011 National Health survey. A linear regression analysis was performed to evaluate potential associations between the evaluated factors and HRQoL. Results: 205 patients answered to the questionnaire. HRQoL of the COVID-19 ARDS patients was significantly lower than the matched populations in both physical and mental dimensions. Age, sex, number of comorbidities, ARDS class, duration of invasive mechanical ventilation, and occupational status were found to be significant determinants of the 90 days HRQoL. Clinical severity at ICU admission was poorly correlated to HRQoL. Conclusion: COVID-19-related ARDS survivors at 90 days after ICU discharge present a significant reduction both on physical and psychological dimensions of HRQoL measured with the 15D instrument. Trial Registration: NCT04411459. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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