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Wide‐field choroidal thickness and vascularity index in myopes and emmetropes.

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Title: Wide‐field choroidal thickness and vascularity index in myopes and emmetropes.
Authors: Yazdani, Negareh (AUTHOR), Ehsaei, Asieh (AUTHOR), Hoseini‐Yazdi, Hosein (AUTHOR), Shoeibi, Nasser (AUTHOR), Alonso‐Caneiro, David (AUTHOR), Collins, Michael J (AUTHOR)
Source: Ophthalmic & Physiological Optics. Nov2021, Vol. 41 Issue 6, p1308-1319. 12p. 1 Color Photograph, 1 Black and White Photograph, 1 Chart, 4 Graphs.
Subjects: Choroid, Optical coherence tomography, Refractive errors, Young adults
Abstract: Purpose: To study regional variations in choroidal thickness (CT), luminal thickness and stromal thickness of the choroid, and choroidal vascularity index (CVI) in low myopic and emmetropic eyes using wide‐field optical coherence tomography (OCT). Methods: Sixty‐nine healthy young adults between 20 and 38 years of age participated in this study, including 40 low myopes (mean ± SD spherical equivalent (MSE) refractive error: −3.00 ± 1.39 D, range: −6.00 to −0.62 D) and 29 emmetropes (MSE: −0.05 ± 0.09 D, range: −0.25 to +0.12 D). Wide‐field CT, luminal thickness, stromal thickness and CVI were measured across five eccentricities (fovea, parafovea, perifovea; near‐periphery and periphery) and four quadrants (nasal, temporal, inferior and superior), in vertical and horizontal meridians, while controlling for a range of extraneous factors potentially influencing the CT. Custom‐written software was used to segment and binarize the OCT images. Results: Wide‐field CT, luminal thickness and stromal thickness, averaged across all participants, exhibited significant topographical variation, with the foveal (379 ± 8 µm, 200 ± 4 µm, 179 ± 4 µm, respectively) and peripheral (275 ± 8 µm, 161 ± 4 µm, 114 ± 4 µm, respectively) regions presenting the thickest and thinnest regions (all p < 0.001). Wide‐field CVI showed a progressively higher percentage (greater vascularity) with increasing eccentricity from the fovea towards the periphery (p < 0.001). Macular CT and stromal choroidal thickness were significantly thinner in myopes compared to emmetropes (p < 0.05). Myopes (55.7 ± 0.3%) showed a slightly higher CVI compared with emmetropes (54.4 ± 0.4%) (p < 0.05). Conclusions: Low myopia in young adults was associated with significant choroidal thinning across the macular, but not extramacular regions, with this decrease in choroidal thickness mostly attributed to thinning in the stromal component of the choroid, rather than the luminal (vascular) component. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Wide‐field choroidal thickness and vascularity index in myopes and emmetropes.
– Name: Author
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yazdani%2C+Negareh%22&quot;&gt;Yazdani, Negareh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ehsaei%2C+Asieh%22&quot;&gt;Ehsaei, Asieh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hoseini‐Yazdi%2C+Hosein%22&quot;&gt;Hoseini‐Yazdi, Hosein&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shoeibi%2C+Nasser%22&quot;&gt;Shoeibi, Nasser&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Alonso‐Caneiro%2C+David%22&quot;&gt;Alonso‐Caneiro, David&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Collins%2C+Michael+J%22&quot;&gt;Collins, Michael J&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Ophthalmic+%26+Physiological+Optics%22&quot;&gt;Ophthalmic &amp; Physiological Optics&lt;/searchLink&gt;. Nov2021, Vol. 41 Issue 6, p1308-1319. 12p. 1 Color Photograph, 1 Black and White Photograph, 1 Chart, 4 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Choroid%22&quot;&gt;Choroid&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Optical+coherence+tomography%22&quot;&gt;Optical coherence tomography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Refractive+errors%22&quot;&gt;Refractive errors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Young+adults%22&quot;&gt;Young adults&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To study regional variations in choroidal thickness (CT), luminal thickness and stromal thickness of the choroid, and choroidal vascularity index (CVI) in low myopic and emmetropic eyes using wide‐field optical coherence tomography (OCT). Methods: Sixty‐nine healthy young adults between 20 and 38 years of age participated in this study, including 40 low myopes (mean &#177; SD spherical equivalent (MSE) refractive error: −3.00 &#177; 1.39 D, range: −6.00 to −0.62 D) and 29 emmetropes (MSE: −0.05 &#177; 0.09 D, range: −0.25 to +0.12 D). Wide‐field CT, luminal thickness, stromal thickness and CVI were measured across five eccentricities (fovea, parafovea, perifovea; near‐periphery and periphery) and four quadrants (nasal, temporal, inferior and superior), in vertical and horizontal meridians, while controlling for a range of extraneous factors potentially influencing the CT. Custom‐written software was used to segment and binarize the OCT images. Results: Wide‐field CT, luminal thickness and stromal thickness, averaged across all participants, exhibited significant topographical variation, with the foveal (379 &#177; 8 &#181;m, 200 &#177; 4 &#181;m, 179 &#177; 4 &#181;m, respectively) and peripheral (275 &#177; 8 &#181;m, 161 &#177; 4 &#181;m, 114 &#177; 4 &#181;m, respectively) regions presenting the thickest and thinnest regions (all p &lt; 0.001). Wide‐field CVI showed a progressively higher percentage (greater vascularity) with increasing eccentricity from the fovea towards the periphery (p &lt; 0.001). Macular CT and stromal choroidal thickness were significantly thinner in myopes compared to emmetropes (p &lt; 0.05). Myopes (55.7 &#177; 0.3%) showed a slightly higher CVI compared with emmetropes (54.4 &#177; 0.4%) (p &lt; 0.05). Conclusions: Low myopia in young adults was associated with significant choroidal thinning across the macular, but not extramacular regions, with this decrease in choroidal thickness mostly attributed to thinning in the stromal component of the choroid, rather than the luminal (vascular) component. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Ophthalmic &amp; Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/opo.12875
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1308
    Subjects:
      – SubjectFull: Choroid
        Type: general
      – SubjectFull: Optical coherence tomography
        Type: general
      – SubjectFull: Refractive errors
        Type: general
      – SubjectFull: Young adults
        Type: general
    Titles:
      – TitleFull: Wide‐field choroidal thickness and vascularity index in myopes and emmetropes.
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            NameFull: Yazdani, Negareh
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            NameFull: Ehsaei, Asieh
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            NameFull: Hoseini‐Yazdi, Hosein
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            NameFull: Shoeibi, Nasser
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            – D: 01
              M: 11
              Text: Nov2021
              Type: published
              Y: 2021
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              Value: 02755408
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              Value: 41
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