View in EDS PDF Full Text

Risk of non-fatal overdose and polysubstance use in a longitudinal study with people who inject drugs in Tijuana, Mexico.

Saved in:
Bibliographic Details
Title: Risk of non-fatal overdose and polysubstance use in a longitudinal study with people who inject drugs in Tijuana, Mexico.
Authors: Rivera Saldana, Carlos D. (AUTHOR), Abramovitz, Daniela (AUTHOR), Meacham, Meredith C. (AUTHOR), Gonzalez‐Zuniga, Patricia (AUTHOR), Rafful, Claudia (AUTHOR), Rangel, Gudelia (AUTHOR), Strathdee, Steffanie A. (AUTHOR), Cepeda, Javier (AUTHOR), Gonzalez-Zuniga, Patricia (AUTHOR)
Source: Drug & Alcohol Review. Nov2021, Vol. 40 Issue 7, p1340-1348. 9p. 3 Charts, 1 Graph.
Subjects: Longitudinal method, Drug utilization, Substance abuse, Drug overdose, Harm reduction, Research, Intravenous drug abuse, Research methodology, Evaluation research, Comparative studies, Impact of Event Scale, Research funding, Drug abusers, Disease complications
Geographic Terms: Tijuana (Baja California, Mexico), Mexico
Abstract: Introduction: Among people who inject drugs (PWID), polysubstance use has been associated with fatal and non-fatal overdose (NFOD). However, the risk of overdose due to the cumulative number of various recently used drug types remains unexplored. We estimated the risk of NFOD for different polysubstance use categories among PWID in Tijuana, Mexico.Methods: Data came from 661 participants followed for 2 years in Proyecto El Cuete-IV, an ongoing prospective cohort of PWID. A multivariable Cox model was used to assess the cumulative impact of polysubstance use on the time to NFOD. We used the Cochran-Armitage test to evaluate a dose-response relationship between number of polysubstance use categories and NFOD.Results: We observed 115 NFOD among 1029.2 person-years of follow-up (incidence rate: 11.2 per 100 person-years; 95% confidence interval [CI] 9.3-13.3). Relative to those who used one drug class, the adjusted hazard ratio of NFOD for individuals reporting using two drug classes was 1.11 (95% CI 0.69-1.79), three drug classes was 2.00 (95% CI 1.16-3.44) and for those reporting three compared to two was 1.79 (95% CI 1.09-2.97). A significant Cochran-Armitage trend test (P < 0.001) suggested a dose-response relationship.Discussion and Conclusions: Polysubstance use was associated with increased risk of NFOD with a dose-response relationship over 2 years. We identified a subgroup of PWID at high risk of NFOD who reported concurrent use of opioids, stimulants and benzodiazepines. Prioritising tailored harm reduction and overdose prevention interventions for PWID who use multiple substances in Tijuana is needed. [ABSTRACT FROM AUTHOR]
Copyright of Drug & Alcohol Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 153560828
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Risk of non-fatal overdose and polysubstance use in a longitudinal study with people who inject drugs in Tijuana, Mexico.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rivera+Saldana%2C+Carlos+D%2E%22&quot;&gt;Rivera Saldana, Carlos D.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Abramovitz%2C+Daniela%22&quot;&gt;Abramovitz, Daniela&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meacham%2C+Meredith+C%2E%22&quot;&gt;Meacham, Meredith C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gonzalez‐Zuniga%2C+Patricia%22&quot;&gt;Gonzalez‐Zuniga, Patricia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rafful%2C+Claudia%22&quot;&gt;Rafful, Claudia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rangel%2C+Gudelia%22&quot;&gt;Rangel, Gudelia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strathdee%2C+Steffanie+A%2E%22&quot;&gt;Strathdee, Steffanie A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cepeda%2C+Javier%22&quot;&gt;Cepeda, Javier&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gonzalez-Zuniga%2C+Patricia%22&quot;&gt;Gonzalez-Zuniga, Patricia&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Drug+%26+Alcohol+Review%22&quot;&gt;Drug &amp; Alcohol Review&lt;/searchLink&gt;. Nov2021, Vol. 40 Issue 7, p1340-1348. 9p. 3 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Longitudinal+method%22&quot;&gt;Longitudinal method&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+utilization%22&quot;&gt;Drug utilization&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Substance+abuse%22&quot;&gt;Substance abuse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+overdose%22&quot;&gt;Drug overdose&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Harm+reduction%22&quot;&gt;Harm reduction&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research%22&quot;&gt;Research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intravenous+drug+abuse%22&quot;&gt;Intravenous drug abuse&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+methodology%22&quot;&gt;Research methodology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Evaluation+research%22&quot;&gt;Evaluation research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Comparative+studies%22&quot;&gt;Comparative studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Impact+of+Event+Scale%22&quot;&gt;Impact of Event Scale&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+funding%22&quot;&gt;Research funding&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Drug+abusers%22&quot;&gt;Drug abusers&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+complications%22&quot;&gt;Disease complications&lt;/searchLink&gt;
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Tijuana+%28Baja+California%2C+Mexico%29%22&quot;&gt;Tijuana (Baja California, Mexico)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mexico%22&quot;&gt;Mexico&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Introduction: &lt;/bold&gt;Among people who inject drugs (PWID), polysubstance use has been associated with fatal and non-fatal overdose (NFOD). However, the risk of overdose due to the cumulative number of various recently used drug types remains unexplored. We estimated the risk of NFOD for different polysubstance use categories among PWID in Tijuana, Mexico.&lt;bold&gt;Methods: &lt;/bold&gt;Data came from 661 participants followed for 2 years in Proyecto El Cuete-IV, an ongoing prospective cohort of PWID. A multivariable Cox model was used to assess the cumulative impact of polysubstance use on the time to NFOD. We used the Cochran-Armitage test to evaluate a dose-response relationship between number of polysubstance use categories and NFOD.&lt;bold&gt;Results: &lt;/bold&gt;We observed 115 NFOD among 1029.2 person-years of follow-up (incidence rate: 11.2 per 100 person-years; 95% confidence interval [CI] 9.3-13.3). Relative to those who used one drug class, the adjusted hazard ratio of NFOD for individuals reporting using two drug classes was 1.11 (95% CI 0.69-1.79), three drug classes was 2.00 (95% CI 1.16-3.44) and for those reporting three compared to two was 1.79 (95% CI 1.09-2.97). A significant Cochran-Armitage trend test (P&#160;&lt; 0.001) suggested a dose-response relationship.&lt;bold&gt;Discussion and Conclusions: &lt;/bold&gt;Polysubstance use was associated with increased risk of NFOD with a dose-response relationship over 2 years. We identified a subgroup of PWID at high risk of NFOD who reported concurrent use of opioids, stimulants and benzodiazepines. Prioritising tailored harm reduction and overdose prevention interventions for PWID who use multiple substances in Tijuana is needed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Drug &amp; Alcohol Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=153560828
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/dar.13305
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 1340
    Subjects:
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Drug utilization
        Type: general
      – SubjectFull: Substance abuse
        Type: general
      – SubjectFull: Drug overdose
        Type: general
      – SubjectFull: Harm reduction
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Intravenous drug abuse
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Impact of Event Scale
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Drug abusers
        Type: general
      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: Tijuana (Baja California, Mexico)
        Type: general
      – SubjectFull: Mexico
        Type: general
    Titles:
      – TitleFull: Risk of non-fatal overdose and polysubstance use in a longitudinal study with people who inject drugs in Tijuana, Mexico.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rivera Saldana, Carlos D.
      – PersonEntity:
          Name:
            NameFull: Abramovitz, Daniela
      – PersonEntity:
          Name:
            NameFull: Meacham, Meredith C.
      – PersonEntity:
          Name:
            NameFull: Gonzalez‐Zuniga, Patricia
      – PersonEntity:
          Name:
            NameFull: Rafful, Claudia
      – PersonEntity:
          Name:
            NameFull: Rangel, Gudelia
      – PersonEntity:
          Name:
            NameFull: Strathdee, Steffanie A.
      – PersonEntity:
          Name:
            NameFull: Cepeda, Javier
      – PersonEntity:
          Name:
            NameFull: Gonzalez-Zuniga, Patricia
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 09595236
          Numbering:
            – Type: volume
              Value: 40
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Drug & Alcohol Review
              Type: main
ResultId 1