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Supramammillary regulation of locomotion and hippocampal activity.

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Title: Supramammillary regulation of locomotion and hippocampal activity.
Authors: Farrell, Jordan S., Lovett-Barron, Matthew, Klein, Peter M., Sparks, Fraser T., Gschwind, Tilo, Ortiz, Anna L., Ahanonu, Biafra, Bradbury, Susanna, Terada, Satoshi, Oijala, Mikko, Hwaun, Ernie, Dudok, Barna, Szabo, Gergely, Schnitzer, Mark J., Deisseroth, Karl, Losonczy, Attila, Soltesz, Ivan
Source: Science (pre-March 2025). 12/17/2021, Vol. 374 Issue 6574, p1492-1496. 5p. 1 Diagram, 3 Graphs.
Subjects: Locomotor control, Neurons, Locomotion, Robust control, Automatic control systems, Hippocampal innervation
Abstract: Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from is unclear. We identified neurons in the supramammillary nucleus (SuM) of the rodent hypothalamus that were highly correlated with future locomotor speed and reliably drove locomotion when activated. Robust locomotion control was specifically identified in Tac1 (substance P)–expressing (SuMTac1+) neurons, the activation of which selectively controlled the activity of speed-modulated hippocampal neurons. By contrast, Tac1-deficient (SuMTac1−) cells weakly regulated locomotion but potently controlled the spike timing of hippocampal neurons and were sufficient to entrain local network oscillations. These findings emphasize that the SuM not only regulates basic locomotor activity but also selectively shapes hippocampal neural activity in a manner that may support spatial navigation. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Supramammillary regulation of locomotion and hippocampal activity.
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  Data: <searchLink fieldCode="AR" term="%22Farrell%2C+Jordan+S%2E%22">Farrell, Jordan S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lovett-Barron%2C+Matthew%22">Lovett-Barron, Matthew</searchLink><br /><searchLink fieldCode="AR" term="%22Klein%2C+Peter+M%2E%22">Klein, Peter M.</searchLink><br /><searchLink fieldCode="AR" term="%22Sparks%2C+Fraser+T%2E%22">Sparks, Fraser T.</searchLink><br /><searchLink fieldCode="AR" term="%22Gschwind%2C+Tilo%22">Gschwind, Tilo</searchLink><br /><searchLink fieldCode="AR" term="%22Ortiz%2C+Anna+L%2E%22">Ortiz, Anna L.</searchLink><br /><searchLink fieldCode="AR" term="%22Ahanonu%2C+Biafra%22">Ahanonu, Biafra</searchLink><br /><searchLink fieldCode="AR" term="%22Bradbury%2C+Susanna%22">Bradbury, Susanna</searchLink><br /><searchLink fieldCode="AR" term="%22Terada%2C+Satoshi%22">Terada, Satoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Oijala%2C+Mikko%22">Oijala, Mikko</searchLink><br /><searchLink fieldCode="AR" term="%22Hwaun%2C+Ernie%22">Hwaun, Ernie</searchLink><br /><searchLink fieldCode="AR" term="%22Dudok%2C+Barna%22">Dudok, Barna</searchLink><br /><searchLink fieldCode="AR" term="%22Szabo%2C+Gergely%22">Szabo, Gergely</searchLink><br /><searchLink fieldCode="AR" term="%22Schnitzer%2C+Mark+J%2E%22">Schnitzer, Mark J.</searchLink><br /><searchLink fieldCode="AR" term="%22Deisseroth%2C+Karl%22">Deisseroth, Karl</searchLink><br /><searchLink fieldCode="AR" term="%22Losonczy%2C+Attila%22">Losonczy, Attila</searchLink><br /><searchLink fieldCode="AR" term="%22Soltesz%2C+Ivan%22">Soltesz, Ivan</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 12/17/2021, Vol. 374 Issue 6574, p1492-1496. 5p. 1 Diagram, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Locomotor+control%22">Locomotor control</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Locomotion%22">Locomotion</searchLink><br /><searchLink fieldCode="DE" term="%22Robust+control%22">Robust control</searchLink><br /><searchLink fieldCode="DE" term="%22Automatic+control+systems%22">Automatic control systems</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampal+innervation%22">Hippocampal innervation</searchLink>
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  Data: Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from is unclear. We identified neurons in the supramammillary nucleus (SuM) of the rodent hypothalamus that were highly correlated with future locomotor speed and reliably drove locomotion when activated. Robust locomotion control was specifically identified in Tac1 (substance P)–expressing (SuMTac1+) neurons, the activation of which selectively controlled the activity of speed-modulated hippocampal neurons. By contrast, Tac1-deficient (SuMTac1−) cells weakly regulated locomotion but potently controlled the spike timing of hippocampal neurons and were sufficient to entrain local network oscillations. These findings emphasize that the SuM not only regulates basic locomotor activity but also selectively shapes hippocampal neural activity in a manner that may support spatial navigation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=154186520
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        Value: 10.1126/science.abh4272
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 5
        StartPage: 1492
    Subjects:
      – SubjectFull: Locomotor control
        Type: general
      – SubjectFull: Neurons
        Type: general
      – SubjectFull: Locomotion
        Type: general
      – SubjectFull: Robust control
        Type: general
      – SubjectFull: Automatic control systems
        Type: general
      – SubjectFull: Hippocampal innervation
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      – TitleFull: Supramammillary regulation of locomotion and hippocampal activity.
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              Text: 12/17/2021
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              Y: 2021
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