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Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.

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Title:	Neuropsychological profile of Alzheimer's disease based on amyloid biomarker findings results from a South American cohort.
Authors:	Clarens, Maria Florencia (AUTHOR), Crivelli, Lucia (AUTHOR), Calandri, Ismael (AUTHOR), Chrem Méndez, Patricio (AUTHOR), Martin, María Eugenia (AUTHOR), Russo, María Julieta (AUTHOR), Campos, Jorge (AUTHOR), Surace, Ezequiel (AUTHOR), Vázquez, Silvia (AUTHOR), Sevlever, Gustavo (AUTHOR), Allegri, Ricardo Francisco (AUTHOR)
Source:	Applied Neuropsychology: Adult. May/Jun2022, Vol. 29 Issue 3, p345-350. 6p. 3 Charts, 1 Graph.
Subjects:	Alzheimer's disease diagnosis, Alzheimer's disease, Peptides, Disease complications
Geographic Terms:	South America
Abstract:	Objective: Increased life expectancy and exponential growth of adults suffering from Alzheimer's disease (AD) worldwide, has led to biomarkers incorporation for diagnosis in early stages. Use of neuropsychological testing remains limited. This study aimed to identify which neuropsychological tests best indicated underlying AD pathophysiology.Methods: One hundred and forty-one patients with MCI (Mild Cognitive Impairment) were studied. A neuropsychological test battery based on the Uniform Data Set (UDS) from the Alzheimer's Disease Centers program of the National Institute on Aging (NIA) was performed and amyloid markers recorded; according to presence or absence of amyloid identified by positive PIB-PET findings, or low CSF Aβ42 levels, patients were separated into MCI amyloid-(n:58) and MCI amyloid + (n = 83) cases.Results: Statistical differences were found in all memory tests between groups. Delayed recall score at thirty minutes on the Rey Auditory Verbal Learning Test (AVLT) was the best predictor of amyloid pathology presence (AUC 0.68), followed by AVLT total learning (AUC 0.66) and AVLT Recognition (AUC 0.59) scores, providing useful cut off values in the clinical setting.Conclusions: Use of neuropsychological testing, specifically AVLT scores with cutoff values, contributed to the correct diagnosis of MCI due to AD in this SouthAmerican cohort. [ABSTRACT FROM AUTHOR]
	Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection
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