View in EDS HTML Full Text PDF Full Text

Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.

Saved in:
Bibliographic Details
Title: Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.
Authors: Straathof, Milou (AUTHOR), Blezer, Erwin L. A. (AUTHOR), Smeele, Christel E. (AUTHOR), van Heijningen, Caroline (AUTHOR), van der Toorn, Annette (AUTHOR), Buitelaar, Jan K. (AUTHOR), Glennon, Jeffrey C. (AUTHOR), Otte, Willem M. (AUTHOR), Dijkhuizen, Rick M. (AUTHOR), TACTICS Consortium (AUTHOR), Buitelaar, Jan (AUTHOR), de Ruiter, Saskia (AUTHOR), Naaijen, Jilly (AUTHOR), Akkermans, Sophie (AUTHOR), Mennes, Maarten (AUTHOR), Zwiers, Marcel (AUTHOR), Ilbegi, Shahrzad (AUTHOR), Hennissen, Leonie (AUTHOR), Glennon, Jeffrey (AUTHOR), van de Vondervoort, Ilse (AUTHOR)
Source: Psychopharmacology. Aug2022, Vol. 239 Issue 8, p2457-2470. 14p. 1 Color Photograph, 1 Diagram, 2 Graphs.
Subjects: Compulsive behavior, Rats, Diffusion magnetic resonance imaging, Animal disease models, Memantine, Functional magnetic resonance imaging, Saline injections, Frontal lobe
Abstract: Rationale: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Objective: Our goal was to characterize the acute and chronic effect of memantine treatment on compulsive behavior and frontostriatal network structure and function in an adolescent rat model of compulsivity. Methods: Juvenile Sprague–Dawley rats received repeated quinpirole, resulting in compulsive checking behavior (n = 32; compulsive) or saline injections (n = 32; control). Eight compulsive and control rats received chronic memantine treatment, and eight compulsive and control rats received saline treatment for seven consecutive days between the 10th and 12th quinpirole/saline injection. Compulsive checking behavior was assessed, and structural and functional brain connectivity was measured with diffusion MRI and resting-state fMRI before and after treatment. The other rats received an acute single memantine (compulsive: n = 12; control: n = 12) or saline injection (compulsive: n = 4; control: n = 4) during pharmacological MRI after the 12th quinpirole/saline injection. An additional group of rats received a single memantine injection after a single quinpirole injection (n = 8). Results: Memantine treatment did not affect compulsive checking nor frontostriatal structural and functional connectivity in the quinpirole-induced adolescent rat model. While memantine activated the frontal cortex in control rats, no significant activation responses were measured after single or repeated quinpirole injections. Conclusions: The lack of a memantine treatment effect in quinpirole-induced compulsive adolescent rats may be partly explained by the interaction between glutamatergic and dopaminergic receptors in the brain, which can be evaluated with functional MRI. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 158036252
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Straathof%2C+Milou%22">Straathof, Milou</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blezer%2C+Erwin+L%2E+A%2E%22">Blezer, Erwin L. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smeele%2C+Christel+E%2E%22">Smeele, Christel E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Heijningen%2C+Caroline%22">van Heijningen, Caroline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+der+Toorn%2C+Annette%22">van der Toorn, Annette</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buitelaar%2C+Jan+K%2E%22">Buitelaar, Jan K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glennon%2C+Jeffrey+C%2E%22">Glennon, Jeffrey C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Otte%2C+Willem+M%2E%22">Otte, Willem M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dijkhuizen%2C+Rick+M%2E%22">Dijkhuizen, Rick M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22TACTICS+Consortium%22">TACTICS Consortium</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buitelaar%2C+Jan%22">Buitelaar, Jan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Ruiter%2C+Saskia%22">de Ruiter, Saskia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Naaijen%2C+Jilly%22">Naaijen, Jilly</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akkermans%2C+Sophie%22">Akkermans, Sophie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mennes%2C+Maarten%22">Mennes, Maarten</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zwiers%2C+Marcel%22">Zwiers, Marcel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ilbegi%2C+Shahrzad%22">Ilbegi, Shahrzad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hennissen%2C+Leonie%22">Hennissen, Leonie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glennon%2C+Jeffrey%22">Glennon, Jeffrey</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+de+Vondervoort%2C+Ilse%22">van de Vondervoort, Ilse</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Aug2022, Vol. 239 Issue 8, p2457-2470. 14p. 1 Color Photograph, 1 Diagram, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Compulsive+behavior%22">Compulsive behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+magnetic+resonance+imaging%22">Diffusion magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+disease+models%22">Animal disease models</searchLink><br /><searchLink fieldCode="DE" term="%22Memantine%22">Memantine</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Saline+injections%22">Saline injections</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Rationale: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment. Objective: Our goal was to characterize the acute and chronic effect of memantine treatment on compulsive behavior and frontostriatal network structure and function in an adolescent rat model of compulsivity. Methods: Juvenile Sprague–Dawley rats received repeated quinpirole, resulting in compulsive checking behavior (n = 32; compulsive) or saline injections (n = 32; control). Eight compulsive and control rats received chronic memantine treatment, and eight compulsive and control rats received saline treatment for seven consecutive days between the 10th and 12th quinpirole/saline injection. Compulsive checking behavior was assessed, and structural and functional brain connectivity was measured with diffusion MRI and resting-state fMRI before and after treatment. The other rats received an acute single memantine (compulsive: n = 12; control: n = 12) or saline injection (compulsive: n = 4; control: n = 4) during pharmacological MRI after the 12th quinpirole/saline injection. An additional group of rats received a single memantine injection after a single quinpirole injection (n = 8). Results: Memantine treatment did not affect compulsive checking nor frontostriatal structural and functional connectivity in the quinpirole-induced adolescent rat model. While memantine activated the frontal cortex in control rats, no significant activation responses were measured after single or repeated quinpirole injections. Conclusions: The lack of a memantine treatment effect in quinpirole-induced compulsive adolescent rats may be partly explained by the interaction between glutamatergic and dopaminergic receptors in the brain, which can be evaluated with functional MRI. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=158036252
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00213-022-06139-z
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 2457
    Subjects:
      – SubjectFull: Compulsive behavior
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Diffusion magnetic resonance imaging
        Type: general
      – SubjectFull: Animal disease models
        Type: general
      – SubjectFull: Memantine
        Type: general
      – SubjectFull: Functional magnetic resonance imaging
        Type: general
      – SubjectFull: Saline injections
        Type: general
      – SubjectFull: Frontal lobe
        Type: general
    Titles:
      – TitleFull: Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Straathof, Milou
      – PersonEntity:
          Name:
            NameFull: Blezer, Erwin L. A.
      – PersonEntity:
          Name:
            NameFull: Smeele, Christel E.
      – PersonEntity:
          Name:
            NameFull: van Heijningen, Caroline
      – PersonEntity:
          Name:
            NameFull: van der Toorn, Annette
      – PersonEntity:
          Name:
            NameFull: Buitelaar, Jan K.
      – PersonEntity:
          Name:
            NameFull: Glennon, Jeffrey C.
      – PersonEntity:
          Name:
            NameFull: Otte, Willem M.
      – PersonEntity:
          Name:
            NameFull: Dijkhuizen, Rick M.
      – PersonEntity:
          Name:
            NameFull: TACTICS Consortium
      – PersonEntity:
          Name:
            NameFull: Buitelaar, Jan
      – PersonEntity:
          Name:
            NameFull: de Ruiter, Saskia
      – PersonEntity:
          Name:
            NameFull: Naaijen, Jilly
      – PersonEntity:
          Name:
            NameFull: Akkermans, Sophie
      – PersonEntity:
          Name:
            NameFull: Mennes, Maarten
      – PersonEntity:
          Name:
            NameFull: Zwiers, Marcel
      – PersonEntity:
          Name:
            NameFull: Ilbegi, Shahrzad
      – PersonEntity:
          Name:
            NameFull: Hennissen, Leonie
      – PersonEntity:
          Name:
            NameFull: Glennon, Jeffrey
      – PersonEntity:
          Name:
            NameFull: van de Vondervoort, Ilse
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 00333158
          Numbering:
            – Type: volume
              Value: 239
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Psychopharmacology
              Type: main
ResultId 1