Anti-seizure medication treatment and outcomes in acute ischemic stroke patients undergoing continuous EEG monitoring.
Saved in:
| Title: | Anti-seizure medication treatment and outcomes in acute ischemic stroke patients undergoing continuous EEG monitoring. |
|---|---|
| Authors: | Sanches, Paula R. (AUTHOR), Tabaeizadeh, Mohammad (AUTHOR), Moura, Lidia M. V. R. (AUTHOR), Rosenthal, Eric S. (AUTHOR), Caboclo, Luis Otavio (AUTHOR), Hsu, John (AUTHOR), Patorno, Elisabetta (AUTHOR), Westover, M. Brandon (AUTHOR), Zafar, Sahar F. (AUTHOR) |
| Source: | Neurological Sciences. Sep2022, Vol. 43 Issue 9, p5441-5449. 9p. 1 Chart, 2 Graphs. |
| Abstract: | Objectives: To determine the association of anti-seizure medication (ASM) treatment with outcomes in acute ischemic stroke (AIS) patients undergoing continuous electroencephalography (cEEG). Methods: Retrospective analysis of AIS patients admitted between 2012 and 2019. The following are the inclusion criteria: age ≥ 18 years and ≥ 16 h of cEEG within the first 7 days of admission. ASM treatment exposure was defined as > 48 h of treatment after the first 24 h of cEEG. The primary outcome measure was 90-day mortality, and the secondary outcome was 90-day functional recovery (Modified Ranking Scale 0–3). Propensity scores were used to adjust for baseline covariates and presence of epileptiform abnormalities (seizures, periodic and rhythmic patterns). Results: One hundred thirteen patients met the inclusion criteria; 39 (34.5%) were exposed to ASM. ASM treatment was not associated with 90-day mortality (propensity adjusted HR 1.0 [0.31–3.27], p = 0.999) or functional outcomes (adjusted HR 0.99 [0.32–3.02], p = 0.989), compared to no treatment. Conclusions: In our study, ASM treatment in AIS patients with cEEG abnormalities was not significantly associated with a change in 90-day mortality and functional recovery. Larger comparative effectiveness studies are indicated to identify which acute ischemic stroke patients with cEEG abnormalities benefit most from ASM treatment. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 158563720 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Anti-seizure medication treatment and outcomes in acute ischemic stroke patients undergoing continuous EEG monitoring. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sanches%2C+Paula+R%2E%22">Sanches, Paula R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tabaeizadeh%2C+Mohammad%22">Tabaeizadeh, Mohammad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moura%2C+Lidia+M%2E+V%2E+R%2E%22">Moura, Lidia M. V. R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rosenthal%2C+Eric+S%2E%22">Rosenthal, Eric S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caboclo%2C+Luis+Otavio%22">Caboclo, Luis Otavio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsu%2C+John%22">Hsu, John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patorno%2C+Elisabetta%22">Patorno, Elisabetta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Westover%2C+M%2E+Brandon%22">Westover, M. Brandon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zafar%2C+Sahar+F%2E%22">Zafar, Sahar F.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Sep2022, Vol. 43 Issue 9, p5441-5449. 9p. 1 Chart, 2 Graphs. – Name: Abstract Label: Abstract Group: Ab Data: Objectives: To determine the association of anti-seizure medication (ASM) treatment with outcomes in acute ischemic stroke (AIS) patients undergoing continuous electroencephalography (cEEG). Methods: Retrospective analysis of AIS patients admitted between 2012 and 2019. The following are the inclusion criteria: age ≥ 18 years and ≥ 16 h of cEEG within the first 7 days of admission. ASM treatment exposure was defined as > 48 h of treatment after the first 24 h of cEEG. The primary outcome measure was 90-day mortality, and the secondary outcome was 90-day functional recovery (Modified Ranking Scale 0–3). Propensity scores were used to adjust for baseline covariates and presence of epileptiform abnormalities (seizures, periodic and rhythmic patterns). Results: One hundred thirteen patients met the inclusion criteria; 39 (34.5%) were exposed to ASM. ASM treatment was not associated with 90-day mortality (propensity adjusted HR 1.0 [0.31–3.27], p = 0.999) or functional outcomes (adjusted HR 0.99 [0.32–3.02], p = 0.989), compared to no treatment. Conclusions: In our study, ASM treatment in AIS patients with cEEG abnormalities was not significantly associated with a change in 90-day mortality and functional recovery. Larger comparative effectiveness studies are indicated to identify which acute ischemic stroke patients with cEEG abnormalities benefit most from ASM treatment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=158563720 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-022-06183-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 5441 Titles: – TitleFull: Anti-seizure medication treatment and outcomes in acute ischemic stroke patients undergoing continuous EEG monitoring. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sanches, Paula R. – PersonEntity: Name: NameFull: Tabaeizadeh, Mohammad – PersonEntity: Name: NameFull: Moura, Lidia M. V. R. – PersonEntity: Name: NameFull: Rosenthal, Eric S. – PersonEntity: Name: NameFull: Caboclo, Luis Otavio – PersonEntity: Name: NameFull: Hsu, John – PersonEntity: Name: NameFull: Patorno, Elisabetta – PersonEntity: Name: NameFull: Westover, M. Brandon – PersonEntity: Name: NameFull: Zafar, Sahar F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 43 – Type: issue Value: 9 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
