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The role of central serotonergic markers and estradiol changes in perinatal mental health.

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Title: The role of central serotonergic markers and estradiol changes in perinatal mental health.
Authors: Borgsted, Camilla (AUTHOR), Høgh, Stinne (AUTHOR), Høgsted, Emma Sofie (AUTHOR), Fonnesbech‐Sandberg, Laura (AUTHOR), Ekelund, Kim (AUTHOR), Albrechtsen, Charlotte Krebs (AUTHOR), Wiis, Julie Therese (AUTHOR), Hegaard, Hanne (AUTHOR), Cvetanovska, Eleonora (AUTHOR), Juul, Anders (AUTHOR), Frederiksen, Hanne (AUTHOR), Pinborg, Anja (AUTHOR), Weikop, Pia (AUTHOR), Frokjaer, Vibe (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Oct2022, Vol. 146 Issue 4, p357-369. 13p. 1 Diagram, 2 Charts, 1 Graph.
Subjects: Liquid chromatography-mass spectrometry, Edinburgh Postnatal Depression Scale, Estradiol, High performance liquid chromatography, Psychological distress
Abstract: Objective: Women have an increased risk for mental distress and depressive symptoms in relation to pregnancy and birth. The serotonin transporter (SERT) may be involved in the emergence of depressive symptoms postpartum and during other sex‐hormone transitions. It may be associated with cerebrospinal fluid (CSF) levels of the main serotonin metabolite 5‐hydroxyindolacetic acid (5‐HIAA). In 100 healthy pregnant women, who were scheduled to deliver by cesarean section (C‐section), we evaluated 5‐HIAA and estradiol contributions to mental distress 5 weeks postpartum. Methods: Eighty‐two women completed the study. CSF collected at C‐section was analyzed for 5‐HIAA, with high performance liquid chromatography. Serum estradiol concentrations were quantified by liquid chromatography tandem mass spectrometry before C‐section and postpartum. Postpartum mental distress was evaluated with the Edinburgh Postnatal Depression Scale (EPDS). Associations between EPDS, 5‐HIAA, and Δestradiol were evaluated in linear regression models adjusted for age, parity and SERT genotype. Results: Higher levels of postpartum mental distress symptoms were negatively associated with a large decrease in estradiol concentrations (βΔE2 = 0.73, p = 0.007) and, on a trend level, positively associated with high antepartum 5‐HIAA levels (β5‐HIAA = 0.002, p = 0.06). Conclusion: In a cohort of healthy pregnant women, postpartum mental distress was higher in women with high antepartum 5‐HIAA (trend) and lower in women with a large perinatal estradiol decrease. We speculate that high antepartum 5‐HIAA is a proxy of SERT levels, that carry over to the postpartum period and convey susceptibility to mental distress. In healthy women, the postpartum return to lower estradiol concentrations may promote mental well‐being. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: The role of central serotonergic markers and estradiol changes in perinatal mental health.
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  Data: <searchLink fieldCode="AR" term="%22Borgsted%2C+Camilla%22">Borgsted, Camilla</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Høgh%2C+Stinne%22">Høgh, Stinne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Høgsted%2C+Emma+Sofie%22">Høgsted, Emma Sofie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fonnesbech‐Sandberg%2C+Laura%22">Fonnesbech‐Sandberg, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ekelund%2C+Kim%22">Ekelund, Kim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Albrechtsen%2C+Charlotte+Krebs%22">Albrechtsen, Charlotte Krebs</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiis%2C+Julie+Therese%22">Wiis, Julie Therese</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hegaard%2C+Hanne%22">Hegaard, Hanne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cvetanovska%2C+Eleonora%22">Cvetanovska, Eleonora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Juul%2C+Anders%22">Juul, Anders</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frederiksen%2C+Hanne%22">Frederiksen, Hanne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pinborg%2C+Anja%22">Pinborg, Anja</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weikop%2C+Pia%22">Weikop, Pia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frokjaer%2C+Vibe%22">Frokjaer, Vibe</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Oct2022, Vol. 146 Issue 4, p357-369. 13p. 1 Diagram, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Edinburgh+Postnatal+Depression+Scale%22">Edinburgh Postnatal Depression Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Estradiol%22">Estradiol</searchLink><br /><searchLink fieldCode="DE" term="%22High+performance+liquid+chromatography%22">High performance liquid chromatography</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+distress%22">Psychological distress</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: Women have an increased risk for mental distress and depressive symptoms in relation to pregnancy and birth. The serotonin transporter (SERT) may be involved in the emergence of depressive symptoms postpartum and during other sex‐hormone transitions. It may be associated with cerebrospinal fluid (CSF) levels of the main serotonin metabolite 5‐hydroxyindolacetic acid (5‐HIAA). In 100 healthy pregnant women, who were scheduled to deliver by cesarean section (C‐section), we evaluated 5‐HIAA and estradiol contributions to mental distress 5 weeks postpartum. Methods: Eighty‐two women completed the study. CSF collected at C‐section was analyzed for 5‐HIAA, with high performance liquid chromatography. Serum estradiol concentrations were quantified by liquid chromatography tandem mass spectrometry before C‐section and postpartum. Postpartum mental distress was evaluated with the Edinburgh Postnatal Depression Scale (EPDS). Associations between EPDS, 5‐HIAA, and Δestradiol were evaluated in linear regression models adjusted for age, parity and SERT genotype. Results: Higher levels of postpartum mental distress symptoms were negatively associated with a large decrease in estradiol concentrations (βΔE2 = 0.73, p = 0.007) and, on a trend level, positively associated with high antepartum 5‐HIAA levels (β5‐HIAA = 0.002, p = 0.06). Conclusion: In a cohort of healthy pregnant women, postpartum mental distress was higher in women with high antepartum 5‐HIAA (trend) and lower in women with a large perinatal estradiol decrease. We speculate that high antepartum 5‐HIAA is a proxy of SERT levels, that carry over to the postpartum period and convey susceptibility to mental distress. In healthy women, the postpartum return to lower estradiol concentrations may promote mental well‐being. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/acps.13461
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      – Code: eng
        Text: English
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        PageCount: 13
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      – SubjectFull: Liquid chromatography-mass spectrometry
        Type: general
      – SubjectFull: Edinburgh Postnatal Depression Scale
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      – SubjectFull: Estradiol
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      – SubjectFull: High performance liquid chromatography
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      – SubjectFull: Psychological distress
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              Text: Oct2022
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