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Identification of hyper‐ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience.

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Title: Identification of hyper‐ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience.
Authors: Fujikawa, Risako (AUTHOR), Jinno, Shozo (AUTHOR)
Source: European Journal of Neuroscience. Oct2022, Vol. 56 Issue 8, p5137-5153. 17p. 2 Charts, 6 Graphs.
Subjects: Social defeat, Microglia, Hippocampus (Brain), Laboratory mice, Neural transmission, Immobilization stress
Abstract: Recent studies have indicated that some individuals are less affected by stress, and such individuals are called resilient. This study aimed to determine whether the specific phenotype of microglia might be involved in resilience using the social defeat stress paradigm. Male C57BL/6J (B6) mice were attacked by aggressive male ICR mice for five consecutive days. After stress exposure, the social behaviour was reduced in about half of the B6 mice (vulnerable), whereas no such change was observed in the remaining half of the B6 mice (resilient). Anxiety‐like behaviour was increased in vulnerable mice compared with resilient mice and non‐stressed controls. However, depression‐related behaviour was comparable between the three groups. The morphological characteristics of microglia in the CA1 region of the dorsal hippocampus in non‐stressed controls and resilient mice differed from those in vulnerable mice. Interestingly, the voxel densities of GABAergic and glutamatergic synaptic puncta colocalized with microglia were higher in resilient mice than in non‐stressed controls and vulnerable mice. Microglia were then objectively classified into three morphological types by hierarchical cluster analysis. The appearance of type I microglia resembled the so‐called resting ramified microglia and represented the major population of microglia in non‐stressed controls. Type II microglia exhibited a de‐ramified morphology and accounted for 60% of the microglia in vulnerable mice. Type III microglia showed a hyper‐ramified morphology and represented more than half of the microglia in resilient mice. These results suggest that hyper‐ramified microglia in the hippocampus may be associated with stress resilience via the modulation of synaptic transmission. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Identification of hyper‐ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Fujikawa%2C+Risako%22">Fujikawa, Risako</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jinno%2C+Shozo%22">Jinno, Shozo</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2022, Vol. 56 Issue 8, p5137-5153. 17p. 2 Charts, 6 Graphs.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Social+defeat%22">Social defeat</searchLink><br /><searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Immobilization+stress%22">Immobilization stress</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Recent studies have indicated that some individuals are less affected by stress, and such individuals are called resilient. This study aimed to determine whether the specific phenotype of microglia might be involved in resilience using the social defeat stress paradigm. Male C57BL/6J (B6) mice were attacked by aggressive male ICR mice for five consecutive days. After stress exposure, the social behaviour was reduced in about half of the B6 mice (vulnerable), whereas no such change was observed in the remaining half of the B6 mice (resilient). Anxiety‐like behaviour was increased in vulnerable mice compared with resilient mice and non‐stressed controls. However, depression‐related behaviour was comparable between the three groups. The morphological characteristics of microglia in the CA1 region of the dorsal hippocampus in non‐stressed controls and resilient mice differed from those in vulnerable mice. Interestingly, the voxel densities of GABAergic and glutamatergic synaptic puncta colocalized with microglia were higher in resilient mice than in non‐stressed controls and vulnerable mice. Microglia were then objectively classified into three morphological types by hierarchical cluster analysis. The appearance of type I microglia resembled the so‐called resting ramified microglia and represented the major population of microglia in non‐stressed controls. Type II microglia exhibited a de‐ramified morphology and accounted for 60% of the microglia in vulnerable mice. Type III microglia showed a hyper‐ramified morphology and represented more than half of the microglia in resilient mice. These results suggest that hyper‐ramified microglia in the hippocampus may be associated with stress resilience via the modulation of synaptic transmission. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=159726404
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        Value: 10.1111/ejn.15812
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      – Code: eng
        Text: English
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        PageCount: 17
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      – SubjectFull: Social defeat
        Type: general
      – SubjectFull: Microglia
        Type: general
      – SubjectFull: Hippocampus (Brain)
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      – SubjectFull: Laboratory mice
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      – SubjectFull: Neural transmission
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      – SubjectFull: Immobilization stress
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            NameFull: Jinno, Shozo
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              Text: Oct2022
              Type: published
              Y: 2022
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