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Field‐based versus laboratory‐based estimates of muscle quality index in adolescents with and without Down syndrome.

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Title: Field‐based versus laboratory‐based estimates of muscle quality index in adolescents with and without Down syndrome.
Authors: Melo, G. L. R., Moraes, M. R., Nascimento, E. F., Boato, E. M., Beal, F. L. R., Stone, W., da Cunha Nascimento, D.
Source: Journal of Intellectual Disability Research. Dec2022, Vol. 66 Issue 12, p1000-1008. 9p. 1 Chart, 2 Graphs.
Subjects: Body composition, Photon absorptiometry, Analysis of variance, Skeletal muscle, Down syndrome, Cross-sectional method, Comparative studies, Pearson correlation (Statistics), Muscle strength, Hypothesis, Body mass index, Adolescence
Abstract: Background: Low muscle quality index (MQI) is a potential risk of developing functional impairments in older people. However, considering that individuals with Down syndrome (DS) present with a faster decline in biological aging, an investigation on MQI in individuals with DS is necessary. The aims of this present cross‐sectional study were to compare (1) MQI between adolescents with and without DS and (2) evaluate laboratory versus field‐based estimates of MQI. Methods: Fifty‐six adolescents were recruited and separated into two groups: DS (n = 30, 13 boys and 17 girls; age: 12.38 ± 3.07 years) and a control (non‐DS; n = 26, 9 boys and 17 girls; age: 12.46 ± 2.88 years). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual‐energy X‐ray absorptiometry (DXA). Field‐based MQI was quantified from the ratio of hand grip strength (HGS) to body mass index (BMI). For statistical analyses, a two‐way ANOVA was conducted for group comparisons, and a Pearson correlation was used to test the association between field MQI and laboratory MQI. Results: Adolescents with DS displayed lower field (P = 0.001), laboratory MQI estimates (P = 0.001) and HGS (P = 0.001) as compared non‐DS. Also, there was a strong correlation effect between field MQI and laboratory MQI estimates (P < 0.001, R = 0.81). Conclusion: Adolescents with DS have lower field and laboratory MQI compared with adolescents without DS. Simpler field MQI might be used in daily clinical practice, with special attention to those with DS. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Field‐based versus laboratory‐based estimates of muscle quality index in adolescents with and without Down syndrome.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Melo%2C+G%2E+L%2E+R%2E%22&quot;&gt;Melo, G. L. R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Moraes%2C+M%2E+R%2E%22&quot;&gt;Moraes, M. R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nascimento%2C+E%2E+F%2E%22&quot;&gt;Nascimento, E. F.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Boato%2C+E%2E+M%2E%22&quot;&gt;Boato, E. M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Beal%2C+F%2E+L%2E+R%2E%22&quot;&gt;Beal, F. L. R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stone%2C+W%2E%22&quot;&gt;Stone, W.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22da+Cunha+Nascimento%2C+D%2E%22&quot;&gt;da Cunha Nascimento, D.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Intellectual+Disability+Research%22&quot;&gt;Journal of Intellectual Disability Research&lt;/searchLink&gt;. Dec2022, Vol. 66 Issue 12, p1000-1008. 9p. 1 Chart, 2 Graphs.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Low muscle quality index (MQI) is a potential risk of developing functional impairments in older people. However, considering that individuals with Down syndrome (DS) present with a faster decline in biological aging, an investigation on MQI in individuals with DS is necessary. The aims of this present cross‐sectional study were to compare (1) MQI between adolescents with and without DS and (2) evaluate laboratory versus field‐based estimates of MQI. Methods: Fifty‐six adolescents were recruited and separated into two groups: DS (n = 30, 13 boys and 17 girls; age: 12.38 &#177; 3.07 years) and a control (non‐DS; n = 26, 9 boys and 17 girls; age: 12.46 &#177; 2.88 years). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual‐energy X‐ray absorptiometry (DXA). Field‐based MQI was quantified from the ratio of hand grip strength (HGS) to body mass index (BMI). For statistical analyses, a two‐way ANOVA was conducted for group comparisons, and a Pearson correlation was used to test the association between field MQI and laboratory MQI. Results: Adolescents with DS displayed lower field (P = 0.001), laboratory MQI estimates (P = 0.001) and HGS (P = 0.001) as compared non‐DS. Also, there was a strong correlation effect between field MQI and laboratory MQI estimates (P &lt; 0.001, R = 0.81). Conclusion: Adolescents with DS have lower field and laboratory MQI compared with adolescents without DS. Simpler field MQI might be used in daily clinical practice, with special attention to those with DS. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=160001275
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        Value: 10.1111/jir.12959
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      – Code: eng
        Text: English
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        PageCount: 9
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    Subjects:
      – SubjectFull: Body composition
        Type: general
      – SubjectFull: Photon absorptiometry
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Skeletal muscle
        Type: general
      – SubjectFull: Down syndrome
        Type: general
      – SubjectFull: Cross-sectional method
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      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Muscle strength
        Type: general
      – SubjectFull: Hypothesis
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      – SubjectFull: Body mass index
        Type: general
      – SubjectFull: Adolescence
        Type: general
    Titles:
      – TitleFull: Field‐based versus laboratory‐based estimates of muscle quality index in adolescents with and without Down syndrome.
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            NameFull: Melo, G. L. R.
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            NameFull: Nascimento, E. F.
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            NameFull: Boato, E. M.
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              M: 12
              Text: Dec2022
              Type: published
              Y: 2022
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