Emerging findings of glutamate–glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies.
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| Title: | Emerging findings of glutamate–glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies. |
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| Authors: | Vidor, Marcos Vinícius (AUTHOR), Panzenhagen, Alana Castro (AUTHOR), Martins, Alexandre Ribeiro (AUTHOR), Cupertino, Renata Basso (AUTHOR), Bandeira, Cibele Edom (AUTHOR), Picon, Felipe Almeida (AUTHOR), da Silva, Bruna Santos (AUTHOR), Vitola, Eduardo Schneider (AUTHOR), Rohde, Luis Augusto (AUTHOR), Rovaris, Diego Luiz (AUTHOR), Bau, Claiton Henrique Dotto (AUTHOR), Grevet, Eugênio Horácio (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Dec2022, Vol. 272 Issue 8, p1395-1411. 17p. 1 Diagram, 5 Charts, 2 Graphs. |
| Subjects: | Prefrontal cortex, Nuclear magnetic resonance spectroscopy, Hyperactivity, Cerebral cortical thinning, Attention-deficit hyperactivity disorder |
| Abstract: | One of the main challenges in investigating the neurobiology of ADHD is our limited capacity to study its neurochemistry in vivo. Magnetic resonance spectroscopy (MRS) estimates metabolite concentrations within the brain, but approaches and findings have been heterogeneous. To assess differences in brain metabolites between patients with ADHD and healthy controls, we searched 12 databases screening for MRS studies. Studies were divided into 'children and adolescents' and 'adults' and meta-analyses were performed for each brain region with more than five studies. The quality of studies was assessed by the Newcastle–Ottawa Scale. Thirty-three studies met our eligibility criteria, including 874 patients with ADHD. Primary analyses revealed that the right medial frontal area of children with ADHD presented higher concentrations of a composite of glutamate and glutamine (p = 0.02, SMD = 0.53). Glutamate might be implicated in pruning and neurodegenerative processes as an excitotoxin, while glutamine excess might signal a glutamate depletion that could hinder neurotrophic activity. Both neuro metabolites could be implicated in the differential cortical thinning observed in patients with ADHD across all ages. Notably, more homogeneous designs and reporting guidelines are the key factors to determine how suitable MRS is for research and, perhaps, for clinical psychiatry. Results of this meta-analysis provided an overall map of the brain regions evaluated so far, addressed the role of glutamatergic metabolites in the pathophysiology of ADHD, and pointed to new perspectives for consistent use of the tool in the field. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 160179396 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Emerging findings of glutamate–glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vidor%2C+Marcos+Vinícius%22">Vidor, Marcos Vinícius</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panzenhagen%2C+Alana+Castro%22">Panzenhagen, Alana Castro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martins%2C+Alexandre+Ribeiro%22">Martins, Alexandre Ribeiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cupertino%2C+Renata+Basso%22">Cupertino, Renata Basso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bandeira%2C+Cibele+Edom%22">Bandeira, Cibele Edom</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Picon%2C+Felipe+Almeida%22">Picon, Felipe Almeida</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22da+Silva%2C+Bruna+Santos%22">da Silva, Bruna Santos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vitola%2C+Eduardo+Schneider%22">Vitola, Eduardo Schneider</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rohde%2C+Luis+Augusto%22">Rohde, Luis Augusto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rovaris%2C+Diego+Luiz%22">Rovaris, Diego Luiz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bau%2C+Claiton+Henrique+Dotto%22">Bau, Claiton Henrique Dotto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grevet%2C+Eugênio+Horácio%22">Grevet, Eugênio Horácio</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Dec2022, Vol. 272 Issue 8, p1395-1411. 17p. 1 Diagram, 5 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperactivity%22">Hyperactivity</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+cortical+thinning%22">Cerebral cortical thinning</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: One of the main challenges in investigating the neurobiology of ADHD is our limited capacity to study its neurochemistry in vivo. Magnetic resonance spectroscopy (MRS) estimates metabolite concentrations within the brain, but approaches and findings have been heterogeneous. To assess differences in brain metabolites between patients with ADHD and healthy controls, we searched 12 databases screening for MRS studies. Studies were divided into 'children and adolescents' and 'adults' and meta-analyses were performed for each brain region with more than five studies. The quality of studies was assessed by the Newcastle–Ottawa Scale. Thirty-three studies met our eligibility criteria, including 874 patients with ADHD. Primary analyses revealed that the right medial frontal area of children with ADHD presented higher concentrations of a composite of glutamate and glutamine (p = 0.02, SMD = 0.53). Glutamate might be implicated in pruning and neurodegenerative processes as an excitotoxin, while glutamine excess might signal a glutamate depletion that could hinder neurotrophic activity. Both neuro metabolites could be implicated in the differential cortical thinning observed in patients with ADHD across all ages. Notably, more homogeneous designs and reporting guidelines are the key factors to determine how suitable MRS is for research and, perhaps, for clinical psychiatry. Results of this meta-analysis provided an overall map of the brain regions evaluated so far, addressed the role of glutamatergic metabolites in the pathophysiology of ADHD, and pointed to new perspectives for consistent use of the tool in the field. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=160179396 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-022-01397-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1395 Subjects: – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Nuclear magnetic resonance spectroscopy Type: general – SubjectFull: Hyperactivity Type: general – SubjectFull: Cerebral cortical thinning Type: general – SubjectFull: Attention-deficit hyperactivity disorder Type: general Titles: – TitleFull: Emerging findings of glutamate–glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vidor, Marcos Vinícius – PersonEntity: Name: NameFull: Panzenhagen, Alana Castro – PersonEntity: Name: NameFull: Martins, Alexandre Ribeiro – PersonEntity: Name: NameFull: Cupertino, Renata Basso – PersonEntity: Name: NameFull: Bandeira, Cibele Edom – PersonEntity: Name: NameFull: Picon, Felipe Almeida – PersonEntity: Name: NameFull: da Silva, Bruna Santos – PersonEntity: Name: NameFull: Vitola, Eduardo Schneider – PersonEntity: Name: NameFull: Rohde, Luis Augusto – PersonEntity: Name: NameFull: Rovaris, Diego Luiz – PersonEntity: Name: NameFull: Bau, Claiton Henrique Dotto – PersonEntity: Name: NameFull: Grevet, Eugênio Horácio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2022 Type: published Y: 2022 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 272 – Type: issue Value: 8 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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