Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review.
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| Title: | Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review. |
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| Authors: | Wang, Duo-Zi (AUTHOR), Li, Bing-Hu (AUTHOR), Deng, Bin-Lu (AUTHOR), Guo, Fu-Qiang (AUTHOR), Hu, Shan-Shan (AUTHOR), Yu, Neng-Wei (AUTHOR), Liu, Jie (AUTHOR) |
| Source: | Neurological Sciences. Mar2023, Vol. 44 Issue 3, p1069-1072. 4p. 1 Black and White Photograph, 1 Diagram. |
| Subjects: | Anti-NMDA receptor encephalitis, Encephalitis, Magnetic resonance imaging, Loss of consciousness, Neuropsychological tests |
| Abstract: | It has been assumed that patients with strict immunosuppressive treatment after solid organ transplantation have only marginal risk in developing autoimmune encephalitis. We reported a woman in her late 40 s who presented with generalized convulsions and loss of consciousness. After detailed history review, neuropsychological tests, metagenomic next-generation sequencing of serum and cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) brain, and electroencephalogram, she was diagnosed as anti-CASPR2 encephalitis based on the positive anti-CASPR2 auto-antibody in serum and CSF. The patient underwent liver transplantation and has taken lenvatinib for 2 months, in addition to tacrolimus, mycophenotale mofetil, and entecavir administered for half a year. This case was the first report of anti-CASPR2 encephalitis in post–organ transplantation patients. Together with the reports of other encephalitis cases in organ transplantation, it warns the possibility of developing immune-oriented encephalitis in patients undergoing immunosuppression, especially in combination with other treatments of immunomodulatory activity. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 161854532 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wang%2C+Duo-Zi%22">Wang, Duo-Zi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Bing-Hu%22">Li, Bing-Hu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Bin-Lu%22">Deng, Bin-Lu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Fu-Qiang%22">Guo, Fu-Qiang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Shan-Shan%22">Hu, Shan-Shan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Neng-Wei%22">Yu, Neng-Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jie%22">Liu, Jie</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Mar2023, Vol. 44 Issue 3, p1069-1072. 4p. 1 Black and White Photograph, 1 Diagram. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Anti-NMDA+receptor+encephalitis%22">Anti-NMDA receptor encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Encephalitis%22">Encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Loss+of+consciousness%22">Loss of consciousness</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: It has been assumed that patients with strict immunosuppressive treatment after solid organ transplantation have only marginal risk in developing autoimmune encephalitis. We reported a woman in her late 40 s who presented with generalized convulsions and loss of consciousness. After detailed history review, neuropsychological tests, metagenomic next-generation sequencing of serum and cerebrospinal fluid (CSF), magnetic resonance imaging (MRI) brain, and electroencephalogram, she was diagnosed as anti-CASPR2 encephalitis based on the positive anti-CASPR2 auto-antibody in serum and CSF. The patient underwent liver transplantation and has taken lenvatinib for 2 months, in addition to tacrolimus, mycophenotale mofetil, and entecavir administered for half a year. This case was the first report of anti-CASPR2 encephalitis in post–organ transplantation patients. Together with the reports of other encephalitis cases in organ transplantation, it warns the possibility of developing immune-oriented encephalitis in patients undergoing immunosuppression, especially in combination with other treatments of immunomodulatory activity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=161854532 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-022-06560-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 1069 Subjects: – SubjectFull: Anti-NMDA receptor encephalitis Type: general – SubjectFull: Encephalitis Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Loss of consciousness Type: general – SubjectFull: Neuropsychological tests Type: general Titles: – TitleFull: Anti-CASPR2 encephalitis in a liver posttransplant patient receiving immune-suppression and lenvatinib: a case report and literature review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang, Duo-Zi – PersonEntity: Name: NameFull: Li, Bing-Hu – PersonEntity: Name: NameFull: Deng, Bin-Lu – PersonEntity: Name: NameFull: Guo, Fu-Qiang – PersonEntity: Name: NameFull: Hu, Shan-Shan – PersonEntity: Name: NameFull: Yu, Neng-Wei – PersonEntity: Name: NameFull: Liu, Jie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 44 – Type: issue Value: 3 Titles: – TitleFull: Neurological Sciences Type: main |
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