View in EDS HTML Full Text PDF Full Text

Oropharyngeal microbiome in children with adenotonsillar hypertrophy and after adenotonsillectomy.

Saved in:
Bibliographic Details
Title: Oropharyngeal microbiome in children with adenotonsillar hypertrophy and after adenotonsillectomy.
Authors: Teng, Zhi-pan (AUTHOR), Zhang, Jian-ya (AUTHOR), Huang, Qun (AUTHOR)
Source: Acta Oto-Laryngologica. Jun2023, Vol. 143 Issue 6, p507-513. 7p.
Subjects: Academic medical centers, Sequence analysis, Hypertrophy, Adenoidectomy, Children's hospitals, Cross-sectional method, Tonsillectomy, Microbiota, Chi-squared test, Descriptive statistics, Data analysis software, Oropharynx
Abstract (English): The microbiome of tonsils and adenoid in adenotonsillar hypertrophy (ATH) has been profiled. Adenotonsillectomy (AT) is widely used for ATH in children. The variation of the oropharyngeal microecology in children with ATH or after AT have never been studied. Here we aimed to evaluate the change in oropharyngeal microbiome in ATH Children after AT. In this cross-sectional study, throat swabs for microbiome analysis were collected from ATH, AT and control groups. Using 16s rDNA sequencing, this study investigated the characteristics of oropharyngeal microbiome. The α-diversity showed a statistical difference in richness and the β-diversity was significantly different among the three groups. The relative abundance of Haemophilus (member of Proteobacteria) increased but that of Actinomyces (member of Actinobacteriota) decreased in the ATH group compared to those in the AT and control groups, but their abundances showed no statistical difference between the AT and control groups. The oropharyngeal microbial diversity and composition are disrupted in children with ATH and can be restored after AT. This microbiome analysis provides a new understanding about the pathogenesis of ATH in children. In this study, we aimed to evaluate the change in oropharyngeal microbiome in ATH Children after AT. The oropharyngeal microbial diversity and composition are disrupted in children with ATH and can be restored after AT. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 背景：腺样体扁桃体肥大 (ATH) 的扁桃体和腺样体的微生物组已被描述。 腺样体扁桃体切除术 (AT) 广泛用于儿童 ATH患者。ATH 患儿或 接受AT 的患儿的口咽微生态学变化从未被研究过。 目的：评估 ATH 儿童在AT 之后口咽微生物组的变化。 材料和方法：在这项横断面研究中, 从 ATH、AT 和对照组收集咽拭子进行微生物组分析。 使用 16s rDNA 测序, 调查了口咽微生物组的特征。 结果：三组之间, α-多样性在丰富度上有统计学差异, β-多样性有显著的区别。 与 AT 组和对照组相比, ATH 组的嗜血杆菌（Proteobacteria 成员）相对丰度增加, 放线菌（Actinobacteriota成员）减少, 但它们的丰度在AT 和对照组之间在统计上没有差异。 结论：ATH儿童患者的口咽部微生物多样性和组成被损害, 而AT 之后可以恢复。 这种微生物组分析提供了对儿童 ATH 的发病机制的新认识。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 164942661
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Oropharyngeal microbiome in children with adenotonsillar hypertrophy and after adenotonsillectomy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Teng%2C+Zhi-pan%22">Teng, Zhi-pan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jian-ya%22">Zhang, Jian-ya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Qun%22">Huang, Qun</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jun2023, Vol. 143 Issue 6, p507-513. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Sequence+analysis%22">Sequence analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertrophy%22">Hypertrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Adenoidectomy%22">Adenoidectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Children's+hospitals%22">Children's hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Tonsillectomy%22">Tonsillectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiota%22">Microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Oropharynx%22">Oropharynx</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: The microbiome of tonsils and adenoid in adenotonsillar hypertrophy (ATH) has been profiled. Adenotonsillectomy (AT) is widely used for ATH in children. The variation of the oropharyngeal microecology in children with ATH or after AT have never been studied. Here we aimed to evaluate the change in oropharyngeal microbiome in ATH Children after AT. In this cross-sectional study, throat swabs for microbiome analysis were collected from ATH, AT and control groups. Using 16s rDNA sequencing, this study investigated the characteristics of oropharyngeal microbiome. The α-diversity showed a statistical difference in richness and the β-diversity was significantly different among the three groups. The relative abundance of Haemophilus (member of Proteobacteria) increased but that of Actinomyces (member of Actinobacteriota) decreased in the ATH group compared to those in the AT and control groups, but their abundances showed no statistical difference between the AT and control groups. The oropharyngeal microbial diversity and composition are disrupted in children with ATH and can be restored after AT. This microbiome analysis provides a new understanding about the pathogenesis of ATH in children. In this study, we aimed to evaluate the change in oropharyngeal microbiome in ATH Children after AT. The oropharyngeal microbial diversity and composition are disrupted in children with ATH and can be restored after AT. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 背景：腺样体扁桃体肥大 (ATH) 的扁桃体和腺样体的微生物组已被描述。 腺样体扁桃体切除术 (AT) 广泛用于儿童 ATH患者。ATH 患儿或 接受AT 的患儿的口咽微生态学变化从未被研究过。 目的：评估 ATH 儿童在AT 之后口咽微生物组的变化。 材料和方法：在这项横断面研究中, 从 ATH、AT 和对照组收集咽拭子进行微生物组分析。 使用 16s rDNA 测序, 调查了口咽微生物组的特征。 结果：三组之间, α-多样性在丰富度上有统计学差异, β-多样性有显著的区别。 与 AT 组和对照组相比, ATH 组的嗜血杆菌（Proteobacteria 成员）相对丰度增加, 放线菌（Actinobacteriota成员）减少, 但它们的丰度在AT 和对照组之间在统计上没有差异。 结论：ATH儿童患者的口咽部微生物多样性和组成被损害, 而AT 之后可以恢复。 这种微生物组分析提供了对儿童 ATH 的发病机制的新认识。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=164942661
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2023.2219285
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 507
    Subjects:
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Sequence analysis
        Type: general
      – SubjectFull: Hypertrophy
        Type: general
      – SubjectFull: Adenoidectomy
        Type: general
      – SubjectFull: Children's hospitals
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Tonsillectomy
        Type: general
      – SubjectFull: Microbiota
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Oropharynx
        Type: general
    Titles:
      – TitleFull: Oropharyngeal microbiome in children with adenotonsillar hypertrophy and after adenotonsillectomy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Teng, Zhi-pan
      – PersonEntity:
          Name:
            NameFull: Zhang, Jian-ya
      – PersonEntity:
          Name:
            NameFull: Huang, Qun
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 00016489
          Numbering:
            – Type: volume
              Value: 143
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Acta Oto-Laryngologica
              Type: main
ResultId 1