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Amphetamines induce ubiquitin-positive inclusions within striatal cells.

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Title: Amphetamines induce ubiquitin-positive inclusions within striatal cells.
Authors: Fornai, F., Lazzeri, G., Lenzi, P., Gesi, M., Ferrucci, M., Soldani, P., Pellegrini, A., Capobianco, L., De Blasi, A., Ruggieri, S., Paparelli, A.
Source: Neurological Sciences. Oct2003, Vol. 24 Issue 3, p182-183. 2p.
Subjects: Amphetamines, Ubiquitin, GABA, Cells, Nervous system, Dopamine, Neurons
Abstract: The present study explores whether effects induced by amphetamine derivatives on striatal GABA cells might be connected with effects on dopamine (DA) metabolism. Methamphetamine (METH) and 3,4-methylene-dioxymethamphetamine (MDMA, "ecstasy") were administered to C57Black mice following a dosage regimen in which various doses of both drugs were injected i.p. at 2-h intervals. Neuronal inclusions produced under these experimental conditions were examined under electron microscopy. Drugs reducing DA availability prevented inclusion formation; conversely we observed that increasing DA synthesis or impairing physiological DA degradation enhanced the number of inclusions. The present study indicates that the presence of extracellular striatal DA is essential for the production of subcellular alterations induced by amphetamine derivatives. This is in line with a recent hypothesis connecting striatal DA release with degeneration of striatal GABA neurons. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Fornai%2C+F%2E%22">Fornai, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Lazzeri%2C+G%2E%22">Lazzeri, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Lenzi%2C+P%2E%22">Lenzi, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Gesi%2C+M%2E%22">Gesi, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ferrucci%2C+M%2E%22">Ferrucci, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Soldani%2C+P%2E%22">Soldani, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Pellegrini%2C+A%2E%22">Pellegrini, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Capobianco%2C+L%2E%22">Capobianco, L.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Blasi%2C+A%2E%22">De Blasi, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ruggieri%2C+S%2E%22">Ruggieri, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Paparelli%2C+A%2E%22">Paparelli, A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Oct2003, Vol. 24 Issue 3, p182-183. 2p.
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  Data: The present study explores whether effects induced by amphetamine derivatives on striatal GABA cells might be connected with effects on dopamine (DA) metabolism. Methamphetamine (METH) and 3,4-methylene-dioxymethamphetamine (MDMA, "ecstasy") were administered to C57Black mice following a dosage regimen in which various doses of both drugs were injected i.p. at 2-h intervals. Neuronal inclusions produced under these experimental conditions were examined under electron microscopy. Drugs reducing DA availability prevented inclusion formation; conversely we observed that increasing DA synthesis or impairing physiological DA degradation enhanced the number of inclusions. The present study indicates that the presence of extracellular striatal DA is essential for the production of subcellular alterations induced by amphetamine derivatives. This is in line with a recent hypothesis connecting striatal DA release with degeneration of striatal GABA neurons. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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