Response to Comment on “DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification”.
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| Title: | Response to Comment on “DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification”. |
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| Authors: | Lixin Chen (AUTHOR), Pingfang Liu (AUTHOR), Evans Jr., Thomas C. (AUTHOR), Ettwiller, Laurence M. (AUTHOR) |
| Source: | Science (pre-March 2025). 9/28/2018, Vol. 361 Issue 6409, p1-4. 4p. 1 Chart, 2 Graphs. |
| Abstract: | Following the Comment of Stewart et al., we repeated our analysis on sequencing runs from The Cancer Genome Atlas (TCGA) using their suggested parameters.We found signs of oxidative damage in all sequence contexts and irrespective of the sequencing date, reaffirming that DNA damage affects mutation-calling pipelines in their ability to accurately identify somatic variations. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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