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The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9.

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Title: The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9.
Authors: Yuhao Wang, Meng Wang, Jiaxin Chen, Yun Li, Zheng Kuang, Chaitanya Dende, Raj, Prithvi, Quinn, Gabriella, Zehan Hu, Srinivasan, Tarun, Hassell, Brian, Ruhn, Kelly A., Behrendt, Cassie L., Tingbo Liang, Xiaobing Dou, Zhangfa Song, Hooper, Lora V.
Source: Science (pre-March 2025). 8/25/2023, Vol. 381 Issue 6660, p851-857. 7p. 5 Diagrams.
Abstract: The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing the expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar RNA host gene 9) in small intestinal epithelial cells. Snhg9 suppressed the activity of peroxisome proliferator–activated receptor γ (PPARγ)—a central regulator of lipid metabolism—by dissociating the PPARγ inhibitor sirtuin 1 from cell cycle and apoptosis protein 2 (CCAR2). Forced expression of Snhg9 in the intestinal epithelium of conventional mice impaired lipid absorption, reduced body fat, and protected against diet-induced obesity. The microbiota repressed Snhg9 expression through an immune relay encompassing myeloid cells and group 3 innate lymphoid cells. Our findings thus identify an unanticipated role for a lncRNA in microbial control of host metabolism. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9.
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  Data: <searchLink fieldCode="AR" term="%22Yuhao+Wang%22">Yuhao Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Meng+Wang%22">Meng Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Jiaxin+Chen%22">Jiaxin Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Yun+Li%22">Yun Li</searchLink><br /><searchLink fieldCode="AR" term="%22Zheng+Kuang%22">Zheng Kuang</searchLink><br /><searchLink fieldCode="AR" term="%22Chaitanya+Dende%22">Chaitanya Dende</searchLink><br /><searchLink fieldCode="AR" term="%22Raj%2C+Prithvi%22">Raj, Prithvi</searchLink><br /><searchLink fieldCode="AR" term="%22Quinn%2C+Gabriella%22">Quinn, Gabriella</searchLink><br /><searchLink fieldCode="AR" term="%22Zehan+Hu%22">Zehan Hu</searchLink><br /><searchLink fieldCode="AR" term="%22Srinivasan%2C+Tarun%22">Srinivasan, Tarun</searchLink><br /><searchLink fieldCode="AR" term="%22Hassell%2C+Brian%22">Hassell, Brian</searchLink><br /><searchLink fieldCode="AR" term="%22Ruhn%2C+Kelly+A%2E%22">Ruhn, Kelly A.</searchLink><br /><searchLink fieldCode="AR" term="%22Behrendt%2C+Cassie+L%2E%22">Behrendt, Cassie L.</searchLink><br /><searchLink fieldCode="AR" term="%22Tingbo+Liang%22">Tingbo Liang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaobing+Dou%22">Xiaobing Dou</searchLink><br /><searchLink fieldCode="AR" term="%22Zhangfa+Song%22">Zhangfa Song</searchLink><br /><searchLink fieldCode="AR" term="%22Hooper%2C+Lora+V%2E%22">Hooper, Lora V.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 8/25/2023, Vol. 381 Issue 6660, p851-857. 7p. 5 Diagrams.
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  Data: The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing the expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar RNA host gene 9) in small intestinal epithelial cells. Snhg9 suppressed the activity of peroxisome proliferator–activated receptor γ (PPARγ)—a central regulator of lipid metabolism—by dissociating the PPARγ inhibitor sirtuin 1 from cell cycle and apoptosis protein 2 (CCAR2). Forced expression of Snhg9 in the intestinal epithelium of conventional mice impaired lipid absorption, reduced body fat, and protected against diet-induced obesity. The microbiota repressed Snhg9 expression through an immune relay encompassing myeloid cells and group 3 innate lymphoid cells. Our findings thus identify an unanticipated role for a lncRNA in microbial control of host metabolism. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: 8/25/2023
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