The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9.
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| Title: | The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9. |
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| Authors: | Yuhao Wang, Meng Wang, Jiaxin Chen, Yun Li, Zheng Kuang, Chaitanya Dende, Raj, Prithvi, Quinn, Gabriella, Zehan Hu, Srinivasan, Tarun, Hassell, Brian, Ruhn, Kelly A., Behrendt, Cassie L., Tingbo Liang, Xiaobing Dou, Zhangfa Song, Hooper, Lora V. |
| Source: | Science (pre-March 2025). 8/25/2023, Vol. 381 Issue 6660, p851-857. 7p. 5 Diagrams. |
| Abstract: | The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing the expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar RNA host gene 9) in small intestinal epithelial cells. Snhg9 suppressed the activity of peroxisome proliferator–activated receptor γ (PPARγ)—a central regulator of lipid metabolism—by dissociating the PPARγ inhibitor sirtuin 1 from cell cycle and apoptosis protein 2 (CCAR2). Forced expression of Snhg9 in the intestinal epithelium of conventional mice impaired lipid absorption, reduced body fat, and protected against diet-induced obesity. The microbiota repressed Snhg9 expression through an immune relay encompassing myeloid cells and group 3 innate lymphoid cells. Our findings thus identify an unanticipated role for a lncRNA in microbial control of host metabolism. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage. We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing the expression of long noncoding RNA (lncRNA) Snhg9 (small nucleolar RNA host gene 9) in small intestinal epithelial cells. Snhg9 suppressed the activity of peroxisome proliferator–activated receptor γ (PPARγ)—a central regulator of lipid metabolism—by dissociating the PPARγ inhibitor sirtuin 1 from cell cycle and apoptosis protein 2 (CCAR2). Forced expression of Snhg9 in the intestinal epithelium of conventional mice impaired lipid absorption, reduced body fat, and protected against diet-induced obesity. The microbiota repressed Snhg9 expression through an immune relay encompassing myeloid cells and group 3 innate lymphoid cells. Our findings thus identify an unanticipated role for a lncRNA in microbial control of host metabolism. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.ade0522 |
