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Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III).

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Title: Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III).
Authors: Olsen, Bjorn Christian (AUTHOR), Opheim, Randi (AUTHOR), Kristensen, Vendel A. (AUTHOR), Høivik, Marte Lie (AUTHOR), Lund, Charlotte (AUTHOR), Aabrekk, Tone Bergene (AUTHOR), Johansen, Ingunn (AUTHOR), Holten, Kristina (AUTHOR), Strande, Vibeke (AUTHOR), Bengtson, May-Bente (AUTHOR), Ricanek, Petr (AUTHOR), Detlie, Trond Espen (AUTHOR), Bernklev, Tomm (AUTHOR), Jelsness-Jørgensen, Lars-Petter (AUTHOR), Huppertz-Hauss, Gert (AUTHOR)
Source: Quality of Life Research. Oct2023, Vol. 32 Issue 10, p2951-2964. 14p. 2 Diagrams, 2 Charts, 3 Graphs.
Subjects: Ibsen, Henrik, 1828-1906, Inflammatory bowel diseases, Quality of life, Crohn's disease, Ulcerative colitis, Cohort analysis, Longitudinal method
Abstract: Purpose: This unselected, population-based cohort study aimed to determine the level of health-related quality of life (HRQoL) in patients with Crohn's disease (CD) and ulcerative colitis (UC) at the time of diagnosis compared with a reference population and identify the demographic factors, psychosocial measures, and disease activity markers associated with HRQoL. Methods: Adult patients newly diagnosed with CD or UC were prospectively enrolled. HRQoL was measured using the Short Form 36 (SF-36) and Norwegian Inflammatory Bowel Disease Questionnaires. Clinical significance was assessed using Cohen's d effect size and further compared with a Norwegian reference population. Associations between HRQoL and symptom scores, demographic factors, psychosocial measures, and disease activity markers were analyzed. Results: Compared with the Norwegian reference population, patients with CD and UC reported significantly lower scores in all SF-36 dimensions, except for physical functioning. Cohen's d effect sizes for men and women in all SF-36 dimensions were at least moderate, except for bodily pain and emotional role for men with UC and physical functioning for both sexes and diagnoses. In the multivariate regression analysis, depression subscale scores ≥ 8 on the Hospital Anxiety and Depression Scale, substantial fatigue, and high symptom scores were associated with reduced HRQoL. Conclusion: Patients newly diagnosed with CD and UC reported statistically and clinically significantly lower scores in seven of the eight SF-36 dimensions than the reference population. Symptoms of depression, fatigue, and elevated symptom scores were associated with poorer HRQoL. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Health-related quality of life in patients with newly diagnosed inflammatory bowel disease: an observational prospective cohort study (IBSEN III).
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  Data: <searchLink fieldCode="AR" term="%22Olsen%2C+Bjorn+Christian%22">Olsen, Bjorn Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Opheim%2C+Randi%22">Opheim, Randi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kristensen%2C+Vendel+A%2E%22">Kristensen, Vendel A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Høivik%2C+Marte+Lie%22">Høivik, Marte Lie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lund%2C+Charlotte%22">Lund, Charlotte</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aabrekk%2C+Tone+Bergene%22">Aabrekk, Tone Bergene</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Johansen%2C+Ingunn%22">Johansen, Ingunn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Holten%2C+Kristina%22">Holten, Kristina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strande%2C+Vibeke%22">Strande, Vibeke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bengtson%2C+May-Bente%22">Bengtson, May-Bente</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ricanek%2C+Petr%22">Ricanek, Petr</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Detlie%2C+Trond+Espen%22">Detlie, Trond Espen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernklev%2C+Tomm%22">Bernklev, Tomm</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jelsness-Jørgensen%2C+Lars-Petter%22">Jelsness-Jørgensen, Lars-Petter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huppertz-Hauss%2C+Gert%22">Huppertz-Hauss, Gert</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Oct2023, Vol. 32 Issue 10, p2951-2964. 14p. 2 Diagrams, 2 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ibsen%2C+Henrik%2C+1828-1906%22">Ibsen, Henrik, 1828-1906</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+bowel+diseases%22">Inflammatory bowel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Crohn's+disease%22">Crohn's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Ulcerative+colitis%22">Ulcerative colitis</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: This unselected, population-based cohort study aimed to determine the level of health-related quality of life (HRQoL) in patients with Crohn's disease (CD) and ulcerative colitis (UC) at the time of diagnosis compared with a reference population and identify the demographic factors, psychosocial measures, and disease activity markers associated with HRQoL. Methods: Adult patients newly diagnosed with CD or UC were prospectively enrolled. HRQoL was measured using the Short Form 36 (SF-36) and Norwegian Inflammatory Bowel Disease Questionnaires. Clinical significance was assessed using Cohen's d effect size and further compared with a Norwegian reference population. Associations between HRQoL and symptom scores, demographic factors, psychosocial measures, and disease activity markers were analyzed. Results: Compared with the Norwegian reference population, patients with CD and UC reported significantly lower scores in all SF-36 dimensions, except for physical functioning. Cohen's d effect sizes for men and women in all SF-36 dimensions were at least moderate, except for bodily pain and emotional role for men with UC and physical functioning for both sexes and diagnoses. In the multivariate regression analysis, depression subscale scores ≥ 8 on the Hospital Anxiety and Depression Scale, substantial fatigue, and high symptom scores were associated with reduced HRQoL. Conclusion: Patients newly diagnosed with CD and UC reported statistically and clinically significantly lower scores in seven of the eight SF-36 dimensions than the reference population. Symptoms of depression, fatigue, and elevated symptom scores were associated with poorer HRQoL. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s11136-023-03435-9
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        Text: English
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