View in EDS HTML Full Text PDF Full Text

Lifelong restructuring of 3D genome architecture in cerebellar granule cells.

Saved in:
Bibliographic Details
Title: Lifelong restructuring of 3D genome architecture in cerebellar granule cells.
Authors: Longzhi Tan, Shi, Jenny, Moghadami, Siavash, Parasar, Bibudha, Wright, Cydney P., Yunji Seo, Vallejo, Kristen, Cobos, Inma, Duncan, Laramie, Ritchie Chen, Deisseroth, Karl
Source: Science (pre-March 2025). 9/8/2023, Vol. 381 Issue 6662, p1112-1119. 8p. 5 Diagrams.
Subjects: Granule cells, Genomes, Neural development, Life spans, Cerebellar cortex, Chromosomes
Abstract: The cerebellum contains most of the neurons in the human brain and exhibits distinctive modes of development and aging. In this work, by developing our single-cell three-dimensional (3D) genome assay—diploid chromosome conformation capture, or Dip-C—into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we resolved the first 3D genome structures of single cerebellar cells, created life-spanning 3D genome atlases for both humans and mice, and jointly measured transcriptome and chromatin accessibility during development. We found that although the transcriptome and chromatin accessibility of cerebellar granule neurons mature in early postnatal life, 3D genome architecture gradually remodels throughout life, establishing ultra–long-range intrachromosomal contacts and specific interchromosomal contacts that are rarely seen in neurons. These results reveal unexpected evolutionarily conserved molecular processes that underlie distinctive features of neural development and aging across the mammalian life span. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 171798884
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Lifelong restructuring of 3D genome architecture in cerebellar granule cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Longzhi+Tan%22">Longzhi Tan</searchLink><br /><searchLink fieldCode="AR" term="%22Shi%2C+Jenny%22">Shi, Jenny</searchLink><br /><searchLink fieldCode="AR" term="%22Moghadami%2C+Siavash%22">Moghadami, Siavash</searchLink><br /><searchLink fieldCode="AR" term="%22Parasar%2C+Bibudha%22">Parasar, Bibudha</searchLink><br /><searchLink fieldCode="AR" term="%22Wright%2C+Cydney+P%2E%22">Wright, Cydney P.</searchLink><br /><searchLink fieldCode="AR" term="%22Yunji+Seo%22">Yunji Seo</searchLink><br /><searchLink fieldCode="AR" term="%22Vallejo%2C+Kristen%22">Vallejo, Kristen</searchLink><br /><searchLink fieldCode="AR" term="%22Cobos%2C+Inma%22">Cobos, Inma</searchLink><br /><searchLink fieldCode="AR" term="%22Duncan%2C+Laramie%22">Duncan, Laramie</searchLink><br /><searchLink fieldCode="AR" term="%22Ritchie+Chen%22">Ritchie Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Deisseroth%2C+Karl%22">Deisseroth, Karl</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/8/2023, Vol. 381 Issue 6662, p1112-1119. 8p. 5 Diagrams.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Granule+cells%22">Granule cells</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Life+spans%22">Life spans</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+cortex%22">Cerebellar cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Chromosomes%22">Chromosomes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The cerebellum contains most of the neurons in the human brain and exhibits distinctive modes of development and aging. In this work, by developing our single-cell three-dimensional (3D) genome assay—diploid chromosome conformation capture, or Dip-C—into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we resolved the first 3D genome structures of single cerebellar cells, created life-spanning 3D genome atlases for both humans and mice, and jointly measured transcriptome and chromatin accessibility during development. We found that although the transcriptome and chromatin accessibility of cerebellar granule neurons mature in early postnatal life, 3D genome architecture gradually remodels throughout life, establishing ultra–long-range intrachromosomal contacts and specific interchromosomal contacts that are rarely seen in neurons. These results reveal unexpected evolutionarily conserved molecular processes that underlie distinctive features of neural development and aging across the mammalian life span. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=171798884
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.adh3253
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1112
    Subjects:
      – SubjectFull: Granule cells
        Type: general
      – SubjectFull: Genomes
        Type: general
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Life spans
        Type: general
      – SubjectFull: Cerebellar cortex
        Type: general
      – SubjectFull: Chromosomes
        Type: general
    Titles:
      – TitleFull: Lifelong restructuring of 3D genome architecture in cerebellar granule cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Longzhi Tan
      – PersonEntity:
          Name:
            NameFull: Shi, Jenny
      – PersonEntity:
          Name:
            NameFull: Moghadami, Siavash
      – PersonEntity:
          Name:
            NameFull: Parasar, Bibudha
      – PersonEntity:
          Name:
            NameFull: Wright, Cydney P.
      – PersonEntity:
          Name:
            NameFull: Yunji Seo
      – PersonEntity:
          Name:
            NameFull: Vallejo, Kristen
      – PersonEntity:
          Name:
            NameFull: Cobos, Inma
      – PersonEntity:
          Name:
            NameFull: Duncan, Laramie
      – PersonEntity:
          Name:
            NameFull: Ritchie Chen
      – PersonEntity:
          Name:
            NameFull: Deisseroth, Karl
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 08
              M: 09
              Text: 9/8/2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 381
            – Type: issue
              Value: 6662
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1