Dopamine D5 receptor modulates male and female sexual behavior in mice.
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| Title: | Dopamine D5 receptor modulates male and female sexual behavior in mice. |
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| Authors: | Kudwa, A. E., Dominguez-Salazar, E., Cabrera, D. M., Sibley, D. R., Rissman, E. F. |
| Source: | Psychopharmacology. Jul2005, Vol. 180 Issue 2, p206-214. 9p. 2 Charts, 3 Graphs. |
| Subjects: | Animal sexual behavior, Dopamine, Conditioned response, Drugs, Attention-deficit hyperactivity disorder |
| Abstract: | Rationale: Dopamine exerts its actions through at least five receptor (DAR) isoforms. In female rats, D5 DAR may be involved in expression of sexual behavior. We used a D5 knockout (D5KO) mouse to assess the role of D5 DAR in mouse sexual behavior. Both sexes of D5KO mice are fertile and exhibit only minor disruptions in exploratory locomotion, startle, and prepulse inhibition responses. Objective: This study was conducted to characterize the sexual behavior of male and female D5KO mice relative to their WT littermates. Methods: Female WT and D5KO littermates were ovariectomized and given a series of sexual behavior tests after treatment with estradiol benzoate (EB) and progesterone (P). Once sexual performance was optimal the dopamine agonist, apomorphine (APO), was substituted for P. Male mice were observed in pair- and trio- sexual behavior tests. To assess whether the D5 DAR is involved in rewarding aspects of sexual behavior, WT and D5KO male mice were tested for conditioned place preference. Results: Both WT and D5KO females can display receptivity after treatment with EB and P, but APO was only able to facilitate receptivity in EB-primed WT, not in D5KO, mice. Male D5KO mice display normal masculine sexual behavior in mating tests. In conditioned preference tests, WT males formed a conditioned preference for context associated with either intromissions alone or ejaculation as the unconditioned stimulus. In contrast, D5KO males only showed a place preference when ejaculation was paired with the context. Conclusions: In females, the D5 DAR is essential for the actions of dopamine on receptivity. In males, D5 DAR influences rewarding aspects of intromissions. Taken together, the work suggests that the D5 receptor mediates dopamine's action on sexual behavior in both sexes, perhaps via a reward pathway. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 17277298 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dopamine D5 receptor modulates male and female sexual behavior in mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kudwa%2C+A%2E+E%2E%22">Kudwa, A. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Dominguez-Salazar%2C+E%2E%22">Dominguez-Salazar, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Cabrera%2C+D%2E+M%2E%22">Cabrera, D. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Sibley%2C+D%2E+R%2E%22">Sibley, D. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Rissman%2C+E%2E+F%2E%22">Rissman, E. F.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2005, Vol. 180 Issue 2, p206-214. 9p. 2 Charts, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Animal+sexual+behavior%22">Animal sexual behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Conditioned+response%22">Conditioned response</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Dopamine exerts its actions through at least five receptor (DAR) isoforms. In female rats, D5 DAR may be involved in expression of sexual behavior. We used a D5 knockout (D5KO) mouse to assess the role of D5 DAR in mouse sexual behavior. Both sexes of D5KO mice are fertile and exhibit only minor disruptions in exploratory locomotion, startle, and prepulse inhibition responses. Objective: This study was conducted to characterize the sexual behavior of male and female D5KO mice relative to their WT littermates. Methods: Female WT and D5KO littermates were ovariectomized and given a series of sexual behavior tests after treatment with estradiol benzoate (EB) and progesterone (P). Once sexual performance was optimal the dopamine agonist, apomorphine (APO), was substituted for P. Male mice were observed in pair- and trio- sexual behavior tests. To assess whether the D5 DAR is involved in rewarding aspects of sexual behavior, WT and D5KO male mice were tested for conditioned place preference. Results: Both WT and D5KO females can display receptivity after treatment with EB and P, but APO was only able to facilitate receptivity in EB-primed WT, not in D5KO, mice. Male D5KO mice display normal masculine sexual behavior in mating tests. In conditioned preference tests, WT males formed a conditioned preference for context associated with either intromissions alone or ejaculation as the unconditioned stimulus. In contrast, D5KO males only showed a place preference when ejaculation was paired with the context. Conclusions: In females, the D5 DAR is essential for the actions of dopamine on receptivity. In males, D5 DAR influences rewarding aspects of intromissions. Taken together, the work suggests that the D5 receptor mediates dopamine's action on sexual behavior in both sexes, perhaps via a reward pathway. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-005-2150-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 206 Subjects: – SubjectFull: Animal sexual behavior Type: general – SubjectFull: Dopamine Type: general – SubjectFull: Conditioned response Type: general – SubjectFull: Drugs Type: general – SubjectFull: Attention-deficit hyperactivity disorder Type: general Titles: – TitleFull: Dopamine D5 receptor modulates male and female sexual behavior in mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kudwa, A. E. – PersonEntity: Name: NameFull: Dominguez-Salazar, E. – PersonEntity: Name: NameFull: Cabrera, D. M. – PersonEntity: Name: NameFull: Sibley, D. R. – PersonEntity: Name: NameFull: Rissman, E. F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 180 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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