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The Role of a Dopamine-Dependent Limbic–Motor Network in Sensory Motor Processing in Parkinson Disease.

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Title: The Role of a Dopamine-Dependent Limbic–Motor Network in Sensory Motor Processing in Parkinson Disease.
Authors: Mann, Leah G. (AUTHOR), Servant, Mathieu (AUTHOR), Hay, Kaitlyn R. (AUTHOR), Song, Alexander K. (AUTHOR), Trujillo, Paula (AUTHOR), Yan, Bailu (AUTHOR), Kang, Hakmook (AUTHOR), Zald, David (AUTHOR), Donahue, Manus J. (AUTHOR), Logan, Gordon D. (AUTHOR), Claassen, Daniel O. (AUTHOR)
Source: Journal of Cognitive Neuroscience. Nov2023, Vol. 35 Issue 11, p1806-1822. 17p.
Subjects: Parkinson's disease, Sensorimotor integration, Globus pallidus, Control (Psychology), Positron emission tomography
Abstract: Limbic and motor integration is enabled by a mesial temporal to motor cortex network. Parkinson disease (PD) is characterized by a loss of dorsal striatal dopamine but relative preservation of mesolimbic dopamine early in disease, along with changes to motor action control. Here, we studied 47 patients with PD using the Simon conflict task and [ 18 F]fallypride PET imaging. Additionally, a cohort of 16 patients participated in a single-blinded dextroamphetamine (dAMPH) study. Task performance was evaluated using the diffusion model for conflict tasks, which allows for an assessment of interpretable action control processes. First, a voxel-wise examination disclosed a negative relationship, such that longer non-decision time is associated with reduced D2-like binding potential (BPND) in the bilateral putamen, left globus pallidus, and right insula. Second, an ROI analysis revealed a positive relationship, such that shorter non-decision time is associated with reduced D2-like BPND in the amygdala and ventromedial OFC. The difference in non-decision time between off-dAMPH and on-dAMPH trials was positively associated with D2-like BPND in the globus pallidus. These findings support the idea that dysfunction of the traditional striatal–motor loop underlies action control deficits but also suggest that a compensatory parallel limbic–motor loop regulates motor output. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Role of a Dopamine-Dependent Limbic–Motor Network in Sensory Motor Processing in Parkinson Disease.
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  Data: <searchLink fieldCode="AR" term="%22Mann%2C+Leah+G%2E%22">Mann, Leah G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Servant%2C+Mathieu%22">Servant, Mathieu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hay%2C+Kaitlyn+R%2E%22">Hay, Kaitlyn R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Alexander+K%2E%22">Song, Alexander K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Trujillo%2C+Paula%22">Trujillo, Paula</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yan%2C+Bailu%22">Yan, Bailu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang%2C+Hakmook%22">Kang, Hakmook</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zald%2C+David%22">Zald, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donahue%2C+Manus+J%2E%22">Donahue, Manus J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Logan%2C+Gordon+D%2E%22">Logan, Gordon D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Claassen%2C+Daniel+O%2E%22">Claassen, Daniel O.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Cognitive+Neuroscience%22">Journal of Cognitive Neuroscience</searchLink>. Nov2023, Vol. 35 Issue 11, p1806-1822. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Sensorimotor+integration%22">Sensorimotor integration</searchLink><br /><searchLink fieldCode="DE" term="%22Globus+pallidus%22">Globus pallidus</searchLink><br /><searchLink fieldCode="DE" term="%22Control+%28Psychology%29%22">Control (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink>
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  Data: Limbic and motor integration is enabled by a mesial temporal to motor cortex network. Parkinson disease (PD) is characterized by a loss of dorsal striatal dopamine but relative preservation of mesolimbic dopamine early in disease, along with changes to motor action control. Here, we studied 47 patients with PD using the Simon conflict task and [ 18 F]fallypride PET imaging. Additionally, a cohort of 16 patients participated in a single-blinded dextroamphetamine (dAMPH) study. Task performance was evaluated using the diffusion model for conflict tasks, which allows for an assessment of interpretable action control processes. First, a voxel-wise examination disclosed a negative relationship, such that longer non-decision time is associated with reduced D2-like binding potential (BPND) in the bilateral putamen, left globus pallidus, and right insula. Second, an ROI analysis revealed a positive relationship, such that shorter non-decision time is associated with reduced D2-like BPND in the amygdala and ventromedial OFC. The difference in non-decision time between off-dAMPH and on-dAMPH trials was positively associated with D2-like BPND in the globus pallidus. These findings support the idea that dysfunction of the traditional striatal–motor loop underlies action control deficits but also suggest that a compensatory parallel limbic–motor loop regulates motor output. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: The Role of a Dopamine-Dependent Limbic–Motor Network in Sensory Motor Processing in Parkinson Disease.
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              Text: Nov2023
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