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Magnetic resonance imaging characteristics of pediatric pilocytic astrocytoma.

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Title: Magnetic resonance imaging characteristics of pediatric pilocytic astrocytoma.
Authors: Opancina, Valentina (AUTHOR), Esposito, Silvia (AUTHOR), Di Meco, Francesco (AUTHOR), Bruno, Eleonora (AUTHOR), Moscatelli, Marco (AUTHOR), Vetrano, Ignazio G. (AUTHOR), Chiapparini, Luisa (AUTHOR), Opancina, Miljan (AUTHOR), Farinotti, Mariangela (AUTHOR), Zdravkovic, Nebojsa (AUTHOR), Pollo, Bianca (AUTHOR), Marucci, Gianluca (AUTHOR), Doniselli, Fabio M. (AUTHOR)
Source: Neurological Sciences. Nov2023, Vol. 44 Issue 11, p4033-4040. 8p.
Subjects: Magnetic resonance imaging, Astrocytomas, Child patients
Abstract: Purpose: MRI has an important role in diagnosing pilocytic astrocytoma and post-surgical follow-up since the surgical approach has a leading role in its treatment. The purpose of our study is to provide an overview of the typical and atypical MRI findings in a series of pediatric patients with isolated—not NF1-related—pilocytic astrocytomas and to correlate specific MRI patterns with clinical variables. Methods: This is a cross-sectional retrospective study providing the analysis of several clinical and neuroradiological findings from a cohort of pediatric pilocytic astrocytoma, starting from the data collected in the Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB) internal Cancer Registry during an 11-year time period (January 2008–January 2019). Results: Fifty-six patients were included in the study. Median age at diagnosis was 9.4 years; a slight female prevalence was noticed (m/f ratio 44.6%/55.4%). The majority of pPAs had well-defined contours: 51 (91.1%), 47 (88.7%) were hypointense on T1-wi, all of them were hyperintense on T2-wi, 46 (90.2%) were hyperintense on FLAIR, and 48 (85.7%) were heterogeneous on T1-wi and T2-wi sequences. We found positive correlation between pPAs location and age (r = 0.017), and small degree of connection between pPAs location and gender (Cramer's V = 0.268). Conclusions: We presented typical and atypical pPAs MRI findings. Age and tumor location were positevely correlated, while degree of connection between gender and pPAs location was small. All of this may aid clinicians, most of all neuroradiologists, neurosurgeons, and neurologists in proper diagnoses and follow-up of these specific patient population. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Magnetic resonance imaging characteristics of pediatric pilocytic astrocytoma.
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  Data: <searchLink fieldCode="AR" term="%22Opancina%2C+Valentina%22">Opancina, Valentina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Esposito%2C+Silvia%22">Esposito, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di+Meco%2C+Francesco%22">Di Meco, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bruno%2C+Eleonora%22">Bruno, Eleonora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moscatelli%2C+Marco%22">Moscatelli, Marco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vetrano%2C+Ignazio+G%2E%22">Vetrano, Ignazio G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiapparini%2C+Luisa%22">Chiapparini, Luisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Opancina%2C+Miljan%22">Opancina, Miljan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farinotti%2C+Mariangela%22">Farinotti, Mariangela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zdravkovic%2C+Nebojsa%22">Zdravkovic, Nebojsa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pollo%2C+Bianca%22">Pollo, Bianca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marucci%2C+Gianluca%22">Marucci, Gianluca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doniselli%2C+Fabio+M%2E%22">Doniselli, Fabio M.</searchLink> (AUTHOR)
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  Data: Purpose: MRI has an important role in diagnosing pilocytic astrocytoma and post-surgical follow-up since the surgical approach has a leading role in its treatment. The purpose of our study is to provide an overview of the typical and atypical MRI findings in a series of pediatric patients with isolated—not NF1-related—pilocytic astrocytomas and to correlate specific MRI patterns with clinical variables. Methods: This is a cross-sectional retrospective study providing the analysis of several clinical and neuroradiological findings from a cohort of pediatric pilocytic astrocytoma, starting from the data collected in the Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB) internal Cancer Registry during an 11-year time period (January 2008–January 2019). Results: Fifty-six patients were included in the study. Median age at diagnosis was 9.4 years; a slight female prevalence was noticed (m/f ratio 44.6%/55.4%). The majority of pPAs had well-defined contours: 51 (91.1%), 47 (88.7%) were hypointense on T1-wi, all of them were hyperintense on T2-wi, 46 (90.2%) were hyperintense on FLAIR, and 48 (85.7%) were heterogeneous on T1-wi and T2-wi sequences. We found positive correlation between pPAs location and age (r = 0.017), and small degree of connection between pPAs location and gender (Cramer's V = 0.268). Conclusions: We presented typical and atypical pPAs MRI findings. Age and tumor location were positevely correlated, while degree of connection between gender and pPAs location was small. All of this may aid clinicians, most of all neuroradiologists, neurosurgeons, and neurologists in proper diagnoses and follow-up of these specific patient population. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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