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Clinical profile and survival analysis of Alzheimer's disease patients in a Brazilian cohort.

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Title: Clinical profile and survival analysis of Alzheimer's disease patients in a Brazilian cohort.
Authors: de Melo Queiroz, Elisa (AUTHOR), Marques Couto, Christian (AUTHOR), da Cruz Mecone, Cláudio Antônio (AUTHOR), Souza Lima Macedo, Waneska (AUTHOR), Caramelli, Paulo (AUTHOR)
Source: Neurological Sciences. Jan2024, Vol. 45 Issue 1, p129-137. 9p.
Subjects: Alzheimer's patients, Survival analysis (Biometry), Alzheimer's disease, Overall survival, Survival rate
Geographic Terms: Rio de Janeiro (Brazil), Brazil
Abstract: Objective: To investigate the clinical and epidemiological characteristics of a large sample of patients with dementia due to Alzheimer's disease (AD) who were followed up at a cognitive neurology outpatient clinic. Methods: Retrospective, longitudinal, and descriptive design. We collected data from patients with dementia due to AD who visited the outpatient clinic of the SARAH Network of Rehabilitation Hospitals in Rio de Janeiro, Brazil, between May 2009 and June 2019. The evaluated characteristics included age of onset, sex, education, family history, comorbidities, time until diagnosis, and survival rates. Results: Overall, 1434 patients were evaluated, 74% of whom were women, with a mean age at symptom onset of 72.7 years and 75.8 at diagnosis. A positive family history was reported in 602 patients, with a first-degree relative in 86.3% of them. Hypertension was the most prevalent comorbidity, affecting 61.2% of the sample, and 16.2% were classified as having early-onset AD. The mean survival rate for the sample population was 112.8 months (9.4 years). The sample population was positively affected by dyslipidaemia. Conclusions: This study presents a clinical and epidemiological analysis of a large and diverse group of patients with AD. The study confirms previous observations such as a higher prevalence of AD in women, low education among sufferers, and the presence of a family history. The study also found that comorbidities significantly affected patient survival and provides new data on the survival rates of patients with early and late AD in the Brazilian population. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Clinical profile and survival analysis of Alzheimer's disease patients in a Brazilian cohort.
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  Data: <searchLink fieldCode="AR" term="%22de+Melo+Queiroz%2C+Elisa%22">de Melo Queiroz, Elisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marques+Couto%2C+Christian%22">Marques Couto, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22da+Cruz+Mecone%2C+Cláudio+Antônio%22">da Cruz Mecone, Cláudio Antônio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Souza+Lima+Macedo%2C+Waneska%22">Souza Lima Macedo, Waneska</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caramelli%2C+Paulo%22">Caramelli, Paulo</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jan2024, Vol. 45 Issue 1, p129-137. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Overall+survival%22">Overall survival</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+rate%22">Survival rate</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Rio+de+Janeiro+%28Brazil%29%22">Rio de Janeiro (Brazil)</searchLink><br /><searchLink fieldCode="DE" term="%22Brazil%22">Brazil</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: To investigate the clinical and epidemiological characteristics of a large sample of patients with dementia due to Alzheimer's disease (AD) who were followed up at a cognitive neurology outpatient clinic. Methods: Retrospective, longitudinal, and descriptive design. We collected data from patients with dementia due to AD who visited the outpatient clinic of the SARAH Network of Rehabilitation Hospitals in Rio de Janeiro, Brazil, between May 2009 and June 2019. The evaluated characteristics included age of onset, sex, education, family history, comorbidities, time until diagnosis, and survival rates. Results: Overall, 1434 patients were evaluated, 74% of whom were women, with a mean age at symptom onset of 72.7 years and 75.8 at diagnosis. A positive family history was reported in 602 patients, with a first-degree relative in 86.3% of them. Hypertension was the most prevalent comorbidity, affecting 61.2% of the sample, and 16.2% were classified as having early-onset AD. The mean survival rate for the sample population was 112.8 months (9.4 years). The sample population was positively affected by dyslipidaemia. Conclusions: This study presents a clinical and epidemiological analysis of a large and diverse group of patients with AD. The study confirms previous observations such as a higher prevalence of AD in women, low education among sufferers, and the presence of a family history. The study also found that comorbidities significantly affected patient survival and provides new data on the survival rates of patients with early and late AD in the Brazilian population. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jan2024
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