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Retinal Thinning in Adults with Autism Spectrum Disorder.

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Title: Retinal Thinning in Adults with Autism Spectrum Disorder.
Authors: Friedel, Evelyn B. N., Tebartz van Elst, Ludger, Schäfer, Mirjam, Maier, Simon, Runge, Kimon, Küchlin, Sebastian, Reich, Michael, Lagrèze, Wolf A., Kornmeier, Jürgen, Ebert, Dieter, Endres, Dominique, Domschke, Katharina, Nickel, Kathrin
Source: Journal of Autism & Developmental Disorders. Mar2024, Vol. 54 Issue 3, p1143-1156. 14p.
Subjects: Retinal disease diagnosis, Retinal anatomy, Statistics, Regression analysis, Case-control method, Fisher exact test, Mann Whitney U Test, Severity of illness index, Psychological tests, Optical coherence tomography, Autism, Questionnaires, Descriptive statistics, Mental depression, Data analysis software, Statistical models, Data analysis, Comorbidity, Intelligence tests, Symptoms, Adults
Abstract: Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT. Both macular and ONL thickness showed significant inverse associations with the severity of autistic symptoms measured with the Social Responsiveness Scale 2 (SRS-2). Longitudinal studies across different age groups are required to clarify whether retinal changes may represent a possible trait marker. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Retinal Thinning in Adults with Autism Spectrum Disorder.
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  Data: <searchLink fieldCode="AR" term="%22Friedel%2C+Evelyn+B%2E+N%2E%22">Friedel, Evelyn B. N.</searchLink><br /><searchLink fieldCode="AR" term="%22Tebartz+van+Elst%2C+Ludger%22">Tebartz van Elst, Ludger</searchLink><br /><searchLink fieldCode="AR" term="%22Schäfer%2C+Mirjam%22">Schäfer, Mirjam</searchLink><br /><searchLink fieldCode="AR" term="%22Maier%2C+Simon%22">Maier, Simon</searchLink><br /><searchLink fieldCode="AR" term="%22Runge%2C+Kimon%22">Runge, Kimon</searchLink><br /><searchLink fieldCode="AR" term="%22Küchlin%2C+Sebastian%22">Küchlin, Sebastian</searchLink><br /><searchLink fieldCode="AR" term="%22Reich%2C+Michael%22">Reich, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Lagrèze%2C+Wolf+A%2E%22">Lagrèze, Wolf A.</searchLink><br /><searchLink fieldCode="AR" term="%22Kornmeier%2C+Jürgen%22">Kornmeier, Jürgen</searchLink><br /><searchLink fieldCode="AR" term="%22Ebert%2C+Dieter%22">Ebert, Dieter</searchLink><br /><searchLink fieldCode="AR" term="%22Endres%2C+Dominique%22">Endres, Dominique</searchLink><br /><searchLink fieldCode="AR" term="%22Domschke%2C+Katharina%22">Domschke, Katharina</searchLink><br /><searchLink fieldCode="AR" term="%22Nickel%2C+Kathrin%22">Nickel, Kathrin</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Mar2024, Vol. 54 Issue 3, p1143-1156. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Retinal+disease+diagnosis%22">Retinal disease diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Retinal+anatomy%22">Retinal anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Optical+coherence+tomography%22">Optical coherence tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+models%22">Statistical models</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+tests%22">Intelligence tests</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT. Both macular and ONL thickness showed significant inverse associations with the severity of autistic symptoms measured with the Social Responsiveness Scale 2 (SRS-2). Longitudinal studies across different age groups are required to clarify whether retinal changes may represent a possible trait marker. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=175830008
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-022-05882-8
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 1143
    Subjects:
      – SubjectFull: Retinal disease diagnosis
        Type: general
      – SubjectFull: Retinal anatomy
        Type: general
      – SubjectFull: Statistics
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      – SubjectFull: Regression analysis
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      – SubjectFull: Fisher exact test
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      – SubjectFull: Mann Whitney U Test
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      – SubjectFull: Severity of illness index
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      – SubjectFull: Psychological tests
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      – SubjectFull: Optical coherence tomography
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      – SubjectFull: Autism
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      – SubjectFull: Questionnaires
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Mental depression
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      – SubjectFull: Data analysis software
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      – SubjectFull: Statistical models
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      – SubjectFull: Adults
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      – TitleFull: Retinal Thinning in Adults with Autism Spectrum Disorder.
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              Text: Mar2024
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