View in EDS HTML Full Text PDF Full Text

Mucosal melanoma of the head and neck: a retrospective analysis of 34 cases in Japan.

Saved in:
Bibliographic Details
Title: Mucosal melanoma of the head and neck: a retrospective analysis of 34 cases in Japan.
Authors: Tamura, Keiichi (AUTHOR), Kumabe, Yohei (AUTHOR), Kishimoto, Yo (AUTHOR), Kitamura, Morimasa (AUTHOR), Mizuta, Masanobu (AUTHOR), Tamaki, Hisanobu (AUTHOR), Honda, Keigo (AUTHOR), Yamada, Koichiro (AUTHOR), Tanaka, Shinzo (AUTHOR), Kojima, Tsuyoshi (AUTHOR), Asato, Ryo (AUTHOR), Ushiro, Koji (AUTHOR), Shinohara, Shogo (AUTHOR), Takebayashi, Shinji (AUTHOR), Maetani, Toshiki (AUTHOR), Ichimaru, Kazuyuki (AUTHOR), Kitani, Yoshiharu (AUTHOR), Omori, Koichi (AUTHOR)
Source: Acta Oto-Laryngologica. Jan2024, Vol. 144 Issue 1, p82-89. 8p.
Subjects: Melanoma prognosis, Nasal cavity, Melanoma, Head & neck cancer, Mucous membranes, Paranasal sinuses, Retrospective studies, Descriptive statistics, Multivariate analysis, Treatment effectiveness, Statistics, Progression-free survival, Postoperative period, Disease relapse
Geographic Terms: Japan
Abstract (English): Mucosal melanoma of the head and neck (MMHN) is a rare condition. This study aimed to investigate oncological outcomes of surgical intervention in patients with MMHN. The study included 34 patients with MMHN who underwent surgical resection as initial treatment at 10 institutions in Japan between July 2005 and June 2015. Results: The 5-year overall survival (OS), local control rate (LCR), disease-free survival (DFS), and disease-specific survival (DSS) rates were 48.7%, 53.4%, 32.4%, and 55.1%, respectively. Based on multivariate analysis, no independent prognostic factors for the 5-year OS and DSS were found. Based on univariate analysis, the 5-year LCR was worse in patients with lesions in the nasal cavity and paranasal sinuses than in the oral cavity and pharynx. However, no differences in oncological outcomes were identified in relation to primary sites, and postoperative radiotherapy (PORT) and adjuvant systemic therapy did not contribute to improvements in the 5-year OS. No independent prognostic factors for the 5-year OS or DSS were identified. Regional or distant recurrences are often identified, regardless of local control with surgical resection. Difficult control of MMHN with conventional therapeutic strategies, such as surgical intervention, PORT, and systemic therapy, has been suggested. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 头颈部粘膜黑色素瘤(MMHN)是一种罕见疾病。 该研究旨在调查 MMHN 患者手术干预的肿瘤学结果。 该研究纳入了 34 名在2005 年 7 月至 2015 年 6 月期间于日本 10 家机构接受初步治疗手术切除的 MMHN 患者。 5 年总生存率 (OS)、局部控制率 (LCR)、无病生存率 (DFS) 和疾病特异性生存率 (DSS)分别为 48.7%、53.4%、32.4% 和 55.1%。 基于多变量分析, 没有发现5 年 OS 和 DSS 的独立预后因素。 基于单变量分析, 鼻腔和鼻旁窦病变患者的5 年 LCR比口腔和咽病变患者的更差。 然而, 未发现与原发部位相关的肿瘤学结果存在差异, 术后放疗(PORT)和辅助全身治疗对5 年OS的改进没有帮助。 没有确定5 年 OS 或 DSS的独立预后因素。 尽管通过手术切除进行局部控制, 通常会发现区域性或远处复发。 我们认为传统治疗方法, 比如手术干预、PORT 和全身治疗等, 难以控制 MMHN。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 176072856
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mucosal melanoma of the head and neck: a retrospective analysis of 34 cases in Japan.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Tamura%2C+Keiichi%22">Tamura, Keiichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumabe%2C+Yohei%22">Kumabe, Yohei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kishimoto%2C+Yo%22">Kishimoto, Yo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kitamura%2C+Morimasa%22">Kitamura, Morimasa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mizuta%2C+Masanobu%22">Mizuta, Masanobu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tamaki%2C+Hisanobu%22">Tamaki, Hisanobu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Honda%2C+Keigo%22">Honda, Keigo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yamada%2C+Koichiro%22">Yamada, Koichiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tanaka%2C+Shinzo%22">Tanaka, Shinzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kojima%2C+Tsuyoshi%22">Kojima, Tsuyoshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asato%2C+Ryo%22">Asato, Ryo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ushiro%2C+Koji%22">Ushiro, Koji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shinohara%2C+Shogo%22">Shinohara, Shogo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takebayashi%2C+Shinji%22">Takebayashi, Shinji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maetani%2C+Toshiki%22">Maetani, Toshiki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ichimaru%2C+Kazuyuki%22">Ichimaru, Kazuyuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kitani%2C+Yoshiharu%22">Kitani, Yoshiharu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Omori%2C+Koichi%22">Omori, Koichi</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jan2024, Vol. 144 Issue 1, p82-89. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Melanoma+prognosis%22">Melanoma prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22Nasal+cavity%22">Nasal cavity</searchLink><br /><searchLink fieldCode="DE" term="%22Melanoma%22">Melanoma</searchLink><br /><searchLink fieldCode="DE" term="%22Head+%26+neck+cancer%22">Head & neck cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Mucous+membranes%22">Mucous membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Paranasal+sinuses%22">Paranasal sinuses</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Progression-free+survival%22">Progression-free survival</searchLink><br /><searchLink fieldCode="DE" term="%22Postoperative+period%22">Postoperative period</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Japan%22">Japan</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Mucosal melanoma of the head and neck (MMHN) is a rare condition. This study aimed to investigate oncological outcomes of surgical intervention in patients with MMHN. The study included 34 patients with MMHN who underwent surgical resection as initial treatment at 10 institutions in Japan between July 2005 and June 2015. Results: The 5-year overall survival (OS), local control rate (LCR), disease-free survival (DFS), and disease-specific survival (DSS) rates were 48.7%, 53.4%, 32.4%, and 55.1%, respectively. Based on multivariate analysis, no independent prognostic factors for the 5-year OS and DSS were found. Based on univariate analysis, the 5-year LCR was worse in patients with lesions in the nasal cavity and paranasal sinuses than in the oral cavity and pharynx. However, no differences in oncological outcomes were identified in relation to primary sites, and postoperative radiotherapy (PORT) and adjuvant systemic therapy did not contribute to improvements in the 5-year OS. No independent prognostic factors for the 5-year OS or DSS were identified. Regional or distant recurrences are often identified, regardless of local control with surgical resection. Difficult control of MMHN with conventional therapeutic strategies, such as surgical intervention, PORT, and systemic therapy, has been suggested. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 头颈部粘膜黑色素瘤(MMHN)是一种罕见疾病。 该研究旨在调查 MMHN 患者手术干预的肿瘤学结果。 该研究纳入了 34 名在2005 年 7 月至 2015 年 6 月期间于日本 10 家机构接受初步治疗手术切除的 MMHN 患者。 5 年总生存率 (OS)、局部控制率 (LCR)、无病生存率 (DFS) 和疾病特异性生存率 (DSS)分别为 48.7%、53.4%、32.4% 和 55.1%。 基于多变量分析, 没有发现5 年 OS 和 DSS 的独立预后因素。 基于单变量分析, 鼻腔和鼻旁窦病变患者的5 年 LCR比口腔和咽病变患者的更差。 然而, 未发现与原发部位相关的肿瘤学结果存在差异, 术后放疗(PORT)和辅助全身治疗对5 年OS的改进没有帮助。 没有确定5 年 OS 或 DSS的独立预后因素。 尽管通过手术切除进行局部控制, 通常会发现区域性或远处复发。 我们认为传统治疗方法, 比如手术干预、PORT 和全身治疗等, 难以控制 MMHN。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=176072856
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2024.2314590
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 82
    Subjects:
      – SubjectFull: Melanoma prognosis
        Type: general
      – SubjectFull: Nasal cavity
        Type: general
      – SubjectFull: Melanoma
        Type: general
      – SubjectFull: Head & neck cancer
        Type: general
      – SubjectFull: Mucous membranes
        Type: general
      – SubjectFull: Paranasal sinuses
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Progression-free survival
        Type: general
      – SubjectFull: Postoperative period
        Type: general
      – SubjectFull: Disease relapse
        Type: general
      – SubjectFull: Japan
        Type: general
    Titles:
      – TitleFull: Mucosal melanoma of the head and neck: a retrospective analysis of 34 cases in Japan.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tamura, Keiichi
      – PersonEntity:
          Name:
            NameFull: Kumabe, Yohei
      – PersonEntity:
          Name:
            NameFull: Kishimoto, Yo
      – PersonEntity:
          Name:
            NameFull: Kitamura, Morimasa
      – PersonEntity:
          Name:
            NameFull: Mizuta, Masanobu
      – PersonEntity:
          Name:
            NameFull: Tamaki, Hisanobu
      – PersonEntity:
          Name:
            NameFull: Honda, Keigo
      – PersonEntity:
          Name:
            NameFull: Yamada, Koichiro
      – PersonEntity:
          Name:
            NameFull: Tanaka, Shinzo
      – PersonEntity:
          Name:
            NameFull: Kojima, Tsuyoshi
      – PersonEntity:
          Name:
            NameFull: Asato, Ryo
      – PersonEntity:
          Name:
            NameFull: Ushiro, Koji
      – PersonEntity:
          Name:
            NameFull: Shinohara, Shogo
      – PersonEntity:
          Name:
            NameFull: Takebayashi, Shinji
      – PersonEntity:
          Name:
            NameFull: Maetani, Toshiki
      – PersonEntity:
          Name:
            NameFull: Ichimaru, Kazuyuki
      – PersonEntity:
          Name:
            NameFull: Kitani, Yoshiharu
      – PersonEntity:
          Name:
            NameFull: Omori, Koichi
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00016489
          Numbering:
            – Type: volume
              Value: 144
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Acta Oto-Laryngologica
              Type: main
ResultId 1