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Sleep Disturbance in Systemic Sclerosis and the Associations Between Sleep and Pulmonary Hypertension: A Pilot Study.

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Title: Sleep Disturbance in Systemic Sclerosis and the Associations Between Sleep and Pulmonary Hypertension: A Pilot Study.
Alternate Title: Sistemik Sklerozda Uyku Bozukluğu ve Uyku ile Pulmoner Hipertansiyon Arasındaki İlişkilerin Sonuçları: Bir Pilot Çalışma.
Authors: Türk, İpek, Arslan, Didem, Kara, Kezban Aslan, Gök, Duygu Kurt, Çağlıyan, Çağlar Emre, Hanta, İsmail, Ünal, İlker
Source: Journal of Turkish Sleep Medicine. Mar2024, Vol. 11 Issue 1, p45-51. 7p.
Subjects: Pulmonary hypertension, Pilot projects, Insomnia, Hypersomnia, Descriptive statistics, Sleep duration, Systemic scleroderma, Sleep, Sleep apnea syndromes, Rapid eye movement sleep, Polysomnography, Data analysis software, Sleep quality, Sleep disorders, Sleep stages, Disease complications
Abstract (English): Objective: Major differences in sleep architecture are observed in patients with systemic sclerosis (SSc). The aim of this study was to investigate the sleep pattern and frequency of obstructive sleep apnea (OSA) in patients with SSc, and compare sleep patterns in patients with and without pulmonary hypertension (PH). Materials and Methods: Patients with SSc and symptoms of hypersomnia or insomnia who underwent polysomnography examinations were evaluated. The clinical data of patients were obtained from the patient files. The subjects were separated into two groups (PH-positive and PH-negative). OSA was defined as an apnea-hypopnea index (AHI) ≥5. Sleep parameters were evaluated between the groups. Results: Thirty-six patients with SSc (88.9% females; mean age: 53.1±11.2 years), 27 with diffuse SSc, and 9 with limited-type SSc were enrolled in the study. Approximately 30.6% of the patients with SSc had AHI ≥5 and 13.9% of patients had AHI ≥15. Eight patients with SSc (22.2%) had a periodic leg movement index (PMLI) above 5/h. The percentages of patients with AHI ≥5 and AHI ≥15 were 25.9% and 7.4% in the PH-negative group and 44.4% and 33.3% in the PH-positive group, respectively. The duration of the rapid eye movement sleep stage was significantly shorter in patients with SSc and PH than in those without PH (p=0.02). The percentages of patients with PMLI >5/h were 14.8% in the PH-negative group and 44.4% in the PH-positive group (p=0.086). Conclusion: Sleep disorders are more commonly observed in patients with SSc. Furthermore, OSA and PH are associated with SSc. [ABSTRACT FROM AUTHOR]
Abstract (Turkish): Amaç: Sistemik sklerozlu (SSk) hastalarda uyku yapısında önemli farklılıklar bulunur. Bu çalışmanın amacı, SSk hastalarında uyku düzenini ve obstrüktif uyku apne (OUA) sıklığını araştırmak ve pulmoner hipertansiyonu (PH) olan ve olmayan hastalardaki uyku paternlerini karşılaştırmaktı. Gereç ve Yöntem: Polisomnografi incelemesi yapılan hipersomni veya uykusuzluk semptomları olan SSk hastaları değerlendirildi. Hastaların klinik bilgileri hasta dosyalarından elde edildi. Hastalar iki gruba ayrıldı (PH-pozitif ve PH-negatif). OUA, apne-hipopne indeksi (AHİ) ≥5 olarak tanımlandı. Uyku parametreleri gruplar arasında değerlendirildi. Bulgular: Çalışmaya 27 diffüz ve 9 sınırlı tip olmak üzere 36 SSk hastası (%88,9 kadın; ortalama yaş: 53,1±11,2 yıl) alındı. SSk'lu hastaların yaklaşık %30,6'sında AHİ ≥5 ve %13,9'unda AHİ ≥15 idi. SSk'lu sekiz hastada (%22,2) 5/saat'in üzerinde periyodik bacak hareket indeksi (PMLI) vardı. AHİ ≥5 ve AHİ ≥15 olan hasta yüzdeleri sırasıyla PH-negatif grupta %25,9 ve %7,4; PH-pozitif grupta %44,4 ve %33,3 idi. Hızlı göz hareketi uyku evresi süresi PH'si olan SSk hastalarda PH olmayanlara göre anlamlı olarak daha kısaydı (p=0,02). PMLI >5/h olan hastaların yüzdesi PH-negatif grupta %14,8, PHpozitif grupta %44,4 idi (p=0,086). Sonuç: Uyku bozuklukları SSk hastalarında daha sık görülür. Ayrıca SSk hastalarında OUA ve PH ilişkilidir. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Turkish Sleep Medicine is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sleep Disturbance in Systemic Sclerosis and the Associations Between Sleep and Pulmonary Hypertension: A Pilot Study.
– Name: TitleAlt
  Label: Alternate Title
  Group: TiAlt
  Data: Sistemik Sklerozda Uyku Bozukluğu ve Uyku ile Pulmoner Hipertansiyon Arasındaki İlişkilerin Sonuçları: Bir Pilot Çalışma.
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  Data: <searchLink fieldCode="AR" term="%22Türk%2C+İpek%22">Türk, İpek</searchLink><br /><searchLink fieldCode="AR" term="%22Arslan%2C+Didem%22">Arslan, Didem</searchLink><br /><searchLink fieldCode="AR" term="%22Kara%2C+Kezban+Aslan%22">Kara, Kezban Aslan</searchLink><br /><searchLink fieldCode="AR" term="%22Gök%2C+Duygu+Kurt%22">Gök, Duygu Kurt</searchLink><br /><searchLink fieldCode="AR" term="%22Çağlıyan%2C+Çağlar+Emre%22">Çağlıyan, Çağlar Emre</searchLink><br /><searchLink fieldCode="AR" term="%22Hanta%2C+İsmail%22">Hanta, İsmail</searchLink><br /><searchLink fieldCode="AR" term="%22Ünal%2C+İlker%22">Ünal, İlker</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Turkish+Sleep+Medicine%22">Journal of Turkish Sleep Medicine</searchLink>. Mar2024, Vol. 11 Issue 1, p45-51. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Pulmonary+hypertension%22">Pulmonary hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Insomnia%22">Insomnia</searchLink><br /><searchLink fieldCode="DE" term="%22Hypersomnia%22">Hypersomnia</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+duration%22">Sleep duration</searchLink><br /><searchLink fieldCode="DE" term="%22Systemic+scleroderma%22">Systemic scleroderma</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep%22">Sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+apnea+syndromes%22">Sleep apnea syndromes</searchLink><br /><searchLink fieldCode="DE" term="%22Rapid+eye+movement+sleep%22">Rapid eye movement sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Polysomnography%22">Polysomnography</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+quality%22">Sleep quality</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+stages%22">Sleep stages</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Objective: Major differences in sleep architecture are observed in patients with systemic sclerosis (SSc). The aim of this study was to investigate the sleep pattern and frequency of obstructive sleep apnea (OSA) in patients with SSc, and compare sleep patterns in patients with and without pulmonary hypertension (PH). Materials and Methods: Patients with SSc and symptoms of hypersomnia or insomnia who underwent polysomnography examinations were evaluated. The clinical data of patients were obtained from the patient files. The subjects were separated into two groups (PH-positive and PH-negative). OSA was defined as an apnea-hypopnea index (AHI) ≥5. Sleep parameters were evaluated between the groups. Results: Thirty-six patients with SSc (88.9% females; mean age: 53.1±11.2 years), 27 with diffuse SSc, and 9 with limited-type SSc were enrolled in the study. Approximately 30.6% of the patients with SSc had AHI ≥5 and 13.9% of patients had AHI ≥15. Eight patients with SSc (22.2%) had a periodic leg movement index (PMLI) above 5/h. The percentages of patients with AHI ≥5 and AHI ≥15 were 25.9% and 7.4% in the PH-negative group and 44.4% and 33.3% in the PH-positive group, respectively. The duration of the rapid eye movement sleep stage was significantly shorter in patients with SSc and PH than in those without PH (p=0.02). The percentages of patients with PMLI >5/h were 14.8% in the PH-negative group and 44.4% in the PH-positive group (p=0.086). Conclusion: Sleep disorders are more commonly observed in patients with SSc. Furthermore, OSA and PH are associated with SSc. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Turkish)
  Group: Ab
  Data: Amaç: Sistemik sklerozlu (SSk) hastalarda uyku yapısında önemli farklılıklar bulunur. Bu çalışmanın amacı, SSk hastalarında uyku düzenini ve obstrüktif uyku apne (OUA) sıklığını araştırmak ve pulmoner hipertansiyonu (PH) olan ve olmayan hastalardaki uyku paternlerini karşılaştırmaktı. Gereç ve Yöntem: Polisomnografi incelemesi yapılan hipersomni veya uykusuzluk semptomları olan SSk hastaları değerlendirildi. Hastaların klinik bilgileri hasta dosyalarından elde edildi. Hastalar iki gruba ayrıldı (PH-pozitif ve PH-negatif). OUA, apne-hipopne indeksi (AHİ) ≥5 olarak tanımlandı. Uyku parametreleri gruplar arasında değerlendirildi. Bulgular: Çalışmaya 27 diffüz ve 9 sınırlı tip olmak üzere 36 SSk hastası (%88,9 kadın; ortalama yaş: 53,1±11,2 yıl) alındı. SSk'lu hastaların yaklaşık %30,6'sında AHİ ≥5 ve %13,9'unda AHİ ≥15 idi. SSk'lu sekiz hastada (%22,2) 5/saat'in üzerinde periyodik bacak hareket indeksi (PMLI) vardı. AHİ ≥5 ve AHİ ≥15 olan hasta yüzdeleri sırasıyla PH-negatif grupta %25,9 ve %7,4; PH-pozitif grupta %44,4 ve %33,3 idi. Hızlı göz hareketi uyku evresi süresi PH'si olan SSk hastalarda PH olmayanlara göre anlamlı olarak daha kısaydı (p=0,02). PMLI >5/h olan hastaların yüzdesi PH-negatif grupta %14,8, PHpozitif grupta %44,4 idi (p=0,086). Sonuç: Uyku bozuklukları SSk hastalarında daha sık görülür. Ayrıca SSk hastalarında OUA ve PH ilişkilidir. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Turkish Sleep Medicine is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.4274/jtsm.galenos.2023.58661
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 45
    Subjects:
      – SubjectFull: Pulmonary hypertension
        Type: general
      – SubjectFull: Pilot projects
        Type: general
      – SubjectFull: Insomnia
        Type: general
      – SubjectFull: Hypersomnia
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Sleep duration
        Type: general
      – SubjectFull: Systemic scleroderma
        Type: general
      – SubjectFull: Sleep
        Type: general
      – SubjectFull: Sleep apnea syndromes
        Type: general
      – SubjectFull: Rapid eye movement sleep
        Type: general
      – SubjectFull: Polysomnography
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Sleep quality
        Type: general
      – SubjectFull: Sleep disorders
        Type: general
      – SubjectFull: Sleep stages
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: Sleep Disturbance in Systemic Sclerosis and the Associations Between Sleep and Pulmonary Hypertension: A Pilot Study.
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            – D: 01
              M: 03
              Text: Mar2024
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              Y: 2024
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