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Fatigue after spontaneous intracerebral haemorrhage: prevalence and associated factors.

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Title: Fatigue after spontaneous intracerebral haemorrhage: prevalence and associated factors.
Authors: Scopelliti, Giuseppe (AUTHOR), Rossi, Costanza (AUTHOR), Kuchcinski, Grégory (AUTHOR), Boulouis, Grégoire (AUTHOR), Moulin, Solène (AUTHOR), Cordonnier, Charlotte (AUTHOR), Hénon, Hilde (AUTHOR), Casolla, Barbara (AUTHOR)
Source: Neurological Sciences. May2024, Vol. 45 Issue 5, p2127-2135. 9p.
Subjects: Cerebral hemorrhage, Cancer fatigue, Fatigue (Physiology), Cerebral atrophy, Magnetic resonance imaging, Confidence intervals
Abstract: Background: Fatigue is a major complaint in stroke survivors, but data focusing on intracerebral haemorrhage (ICH) survivors are scarce. In a cohort of spontaneous ICH survivors, we assessed the long-term prevalence of fatigue and its associated factors. Methods: We included consecutive 1-year ICH survivors from the prospective, observational, single-centre Prognosis of Intracerebral Haemorrhage (PITCH) study. We evaluated fatigue (defined as a score ≥ 4 in Chalder Fatigue Scale); the severity of neurological, depressive, and anxiety symptoms; and functional disability 1, 3, and 6 years after ICH. We performed univariable and multivariable models to evaluate clinical factors and brain magnetic resonance imaging (MRI) small vessel disease (SVD) markers associated with fatigue. Results: Of 255 1-year ICH survivors, 153 (60%) underwent fatigue screening and were included in this study. Seventy-eight patients (51%) reported fatigue at 1-year, 56/110 (51%) at 3-year, and 27/67 (40%) at 6-year follow-up. Patients with fatigue exhibited more severe concomitant depressive/anxiety symptoms, but the severity of depressive symptoms was the only clinical factor significantly associated with 1-year fatigue in multivariable analysis (adjusted odds ratio 1.4 for one-point increase; 95% confidence interval 1.2–1.6). Patients with severe cortical atrophy at baseline had increased risk of fatigue at 1-year follow-up compared to patients with mild/no cortical atrophy (adjusted odds ratio 2.5; 95% confidence interval 1.1–5.8). Conclusions: Fatigue after ICH is frequent and long-lasting, and it is associated with cortical atrophy (but not with other MRI markers of cerebral SVD). The link between fatigue and depressive symptoms may represent a potential therapeutic target. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Fatigue after spontaneous intracerebral haemorrhage: prevalence and associated factors.
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  Data: <searchLink fieldCode="AR" term="%22Scopelliti%2C+Giuseppe%22">Scopelliti, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rossi%2C+Costanza%22">Rossi, Costanza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuchcinski%2C+Grégory%22">Kuchcinski, Grégory</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boulouis%2C+Grégoire%22">Boulouis, Grégoire</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moulin%2C+Solène%22">Moulin, Solène</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cordonnier%2C+Charlotte%22">Cordonnier, Charlotte</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hénon%2C+Hilde%22">Hénon, Hilde</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Casolla%2C+Barbara%22">Casolla, Barbara</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2024, Vol. 45 Issue 5, p2127-2135. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Cerebral+hemorrhage%22">Cerebral hemorrhage</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+fatigue%22">Cancer fatigue</searchLink><br /><searchLink fieldCode="DE" term="%22Fatigue+%28Physiology%29%22">Fatigue (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+atrophy%22">Cerebral atrophy</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink>
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  Data: Background: Fatigue is a major complaint in stroke survivors, but data focusing on intracerebral haemorrhage (ICH) survivors are scarce. In a cohort of spontaneous ICH survivors, we assessed the long-term prevalence of fatigue and its associated factors. Methods: We included consecutive 1-year ICH survivors from the prospective, observational, single-centre Prognosis of Intracerebral Haemorrhage (PITCH) study. We evaluated fatigue (defined as a score ≥ 4 in Chalder Fatigue Scale); the severity of neurological, depressive, and anxiety symptoms; and functional disability 1, 3, and 6 years after ICH. We performed univariable and multivariable models to evaluate clinical factors and brain magnetic resonance imaging (MRI) small vessel disease (SVD) markers associated with fatigue. Results: Of 255 1-year ICH survivors, 153 (60%) underwent fatigue screening and were included in this study. Seventy-eight patients (51%) reported fatigue at 1-year, 56/110 (51%) at 3-year, and 27/67 (40%) at 6-year follow-up. Patients with fatigue exhibited more severe concomitant depressive/anxiety symptoms, but the severity of depressive symptoms was the only clinical factor significantly associated with 1-year fatigue in multivariable analysis (adjusted odds ratio 1.4 for one-point increase; 95% confidence interval 1.2–1.6). Patients with severe cortical atrophy at baseline had increased risk of fatigue at 1-year follow-up compared to patients with mild/no cortical atrophy (adjusted odds ratio 2.5; 95% confidence interval 1.1–5.8). Conclusions: Fatigue after ICH is frequent and long-lasting, and it is associated with cortical atrophy (but not with other MRI markers of cerebral SVD). The link between fatigue and depressive symptoms may represent a potential therapeutic target. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: May2024
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