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End‐of‐day assessment of asymptomatic versus highly symptomatic soft contact lens wearers.

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Title: End‐of‐day assessment of asymptomatic versus highly symptomatic soft contact lens wearers.
Authors: Maldonado‐Codina, Carole (AUTHOR), Navascues‐Cornago, Maria (AUTHOR), Smith, Sarah L. (AUTHOR), Read, Michael L. (AUTHOR), Lakkis, Carol (AUTHOR), Morgan, Philip B. (AUTHOR)
Source: Ophthalmic & Physiological Optics. Jun2024, Vol. 44 Issue 4, p704-717. 14p.
Subjects: Soft contact lenses, Eyelids
Abstract: Purpose: To investigate differences in key clinical parameters between asymptomatic and highly symptomatic soft contact lens (CL) wearers after 14 h of wear. Methods: In this pilot investigation, Phase 1 identified asymptomatic (CLDEQ‐8 score ≤ 7) and highly symptomatic (CLDEQ‐8 score ≥ 20) subjects after fitting with nelfilcon A CLs. Phase 2 investigated the following over a single nelfilcon A CL‐wearing day (14 ± 2 h): blinking characteristics, tear meniscus height (TMH), non‐invasive tear break‐up time (NIBUT), tear film osmolarity and eyelid margin staining. Parameters for the two groups were compared using linear mixed models and post‐hoc testing. The relationship between comfort scores and the clinical parameters was also investigated. Results: Overall, 161 and 42 subjects were enrolled into Phase 1 and 2, respectively. Twenty‐five asymptomatic and 17 symptomatic subjects completed Phase 2. Lower eyelid TMH was decreased after 14 h in symptomatic compared with asymptomatic subjects (least square mean [LSM] difference −0.04 mm, 95% CI: −0.07, −0.01). Osmolarity was lower in symptomatic than in asymptomatic subjects at fitting (LSM difference −9.89, 95% CI: −18.91, −0.86). Upper eyelid margin staining was greater after 14 h in symptomatic than in asymptomatic subjects (LSM difference 0.53, 95% CI: 0.01, 1.05) and greater after 14 h than baseline in the symptomatic group (LSM difference 0.61, 95% CI: 0.16, 1.07). There was a significant relationship between comfort and upper eyelid margin staining (r = −0.40, 95% CI: −0.63, −0.11) and blink rate (r = −0.31, 95% CI: −0.57, −0.003). Conclusion: The potential parameters most effective in differentiating asymptomatic from symptomatic wearers were upper eyelid margin staining and lower TMH. The parameter with the strongest relationship to comfort was upper eyelid margin staining, where higher comfort scores were associated with lower levels of staining. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: End‐of‐day assessment of asymptomatic versus highly symptomatic soft contact lens wearers.
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  Data: <searchLink fieldCode="AR" term="%22Maldonado‐Codina%2C+Carole%22">Maldonado‐Codina, Carole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Navascues‐Cornago%2C+Maria%22">Navascues‐Cornago, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smith%2C+Sarah+L%2E%22">Smith, Sarah L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Read%2C+Michael+L%2E%22">Read, Michael L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lakkis%2C+Carol%22">Lakkis, Carol</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morgan%2C+Philip+B%2E%22">Morgan, Philip B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Ophthalmic+%26+Physiological+Optics%22">Ophthalmic & Physiological Optics</searchLink>. Jun2024, Vol. 44 Issue 4, p704-717. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Soft+contact+lenses%22">Soft contact lenses</searchLink><br /><searchLink fieldCode="DE" term="%22Eyelids%22">Eyelids</searchLink>
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  Data: Purpose: To investigate differences in key clinical parameters between asymptomatic and highly symptomatic soft contact lens (CL) wearers after 14 h of wear. Methods: In this pilot investigation, Phase 1 identified asymptomatic (CLDEQ‐8 score ≤ 7) and highly symptomatic (CLDEQ‐8 score ≥ 20) subjects after fitting with nelfilcon A CLs. Phase 2 investigated the following over a single nelfilcon A CL‐wearing day (14 ± 2 h): blinking characteristics, tear meniscus height (TMH), non‐invasive tear break‐up time (NIBUT), tear film osmolarity and eyelid margin staining. Parameters for the two groups were compared using linear mixed models and post‐hoc testing. The relationship between comfort scores and the clinical parameters was also investigated. Results: Overall, 161 and 42 subjects were enrolled into Phase 1 and 2, respectively. Twenty‐five asymptomatic and 17 symptomatic subjects completed Phase 2. Lower eyelid TMH was decreased after 14 h in symptomatic compared with asymptomatic subjects (least square mean [LSM] difference −0.04 mm, 95% CI: −0.07, −0.01). Osmolarity was lower in symptomatic than in asymptomatic subjects at fitting (LSM difference −9.89, 95% CI: −18.91, −0.86). Upper eyelid margin staining was greater after 14 h in symptomatic than in asymptomatic subjects (LSM difference 0.53, 95% CI: 0.01, 1.05) and greater after 14 h than baseline in the symptomatic group (LSM difference 0.61, 95% CI: 0.16, 1.07). There was a significant relationship between comfort and upper eyelid margin staining (r = −0.40, 95% CI: −0.63, −0.11) and blink rate (r = −0.31, 95% CI: −0.57, −0.003). Conclusion: The potential parameters most effective in differentiating asymptomatic from symptomatic wearers were upper eyelid margin staining and lower TMH. The parameter with the strongest relationship to comfort was upper eyelid margin staining, where higher comfort scores were associated with lower levels of staining. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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              Text: Jun2024
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