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Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour.

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Title: Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour.
Authors: Pickford, Jasmine (AUTHOR), Iosif, Cristiana I. (AUTHOR), Bashir, Zafar I. (AUTHOR), Apps, Richard (AUTHOR)
Source: European Journal of Neuroscience. May2024, Vol. 59 Issue 9, p2208-2224. 17p.
Subjects: Cholinergic receptors, Cerebellar nuclei, Tropanes, Motor learning, Cholinergic mechanisms, Muscarinic receptors, Muscarinic antagonists, Cerebellum
Abstract: The role of neuromodulators in the cerebellum is not well understood. In particular, the behavioural significance of the cholinergic system in the cerebellum is unknown. To investigate the importance of cerebellar cholinergic signalling in behaviour, we infused acetylcholine receptor antagonists, scopolamine and mecamylamine, bilaterally into the rat cerebellum (centred on interpositus nucleus) and observed the motor effects through a battery of behavioural tests. These tests included unrewarded behaviour during open field exploration and a horizontal ladder walking task and reward‐based beam walking and pellet reaching tasks. Infusion of a mix of the antagonists did not impair motor learning in the horizontal ladder walking or the reaching task but reduced spontaneous movement during open field exploration, impaired coordination during beam walking and ladder walking, led to fewer reaches in the pellet reaching task, slowed goal‐directed reaching behaviour and reduced reward pellet consumption in a free access to food task. Infusion of the muscarinic antagonist scopolamine on its own resulted in deficits in motor performance and a reduction in the number of reward pellets consumed in the free access to food task. By contrast, infusion of the nicotinic antagonist mecamylamine on its own had no significant effect on any task, except beam walking traversal time, which was reduced. Together, these data suggest that acetylcholine in the cerebellar interpositus nucleus is important for the execution and coordination of voluntary movements mainly via muscarinic receptor signalling, especially in relation to reward‐related behaviour. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour.
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  Data: <searchLink fieldCode="AR" term="%22Pickford%2C+Jasmine%22">Pickford, Jasmine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iosif%2C+Cristiana+I%2E%22">Iosif, Cristiana I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bashir%2C+Zafar+I%2E%22">Bashir, Zafar I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Apps%2C+Richard%22">Apps, Richard</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2024, Vol. 59 Issue 9, p2208-2224. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Cholinergic+receptors%22">Cholinergic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellar+nuclei%22">Cerebellar nuclei</searchLink><br /><searchLink fieldCode="DE" term="%22Tropanes%22">Tropanes</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+learning%22">Motor learning</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+mechanisms%22">Cholinergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Muscarinic+receptors%22">Muscarinic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Muscarinic+antagonists%22">Muscarinic antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellum%22">Cerebellum</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The role of neuromodulators in the cerebellum is not well understood. In particular, the behavioural significance of the cholinergic system in the cerebellum is unknown. To investigate the importance of cerebellar cholinergic signalling in behaviour, we infused acetylcholine receptor antagonists, scopolamine and mecamylamine, bilaterally into the rat cerebellum (centred on interpositus nucleus) and observed the motor effects through a battery of behavioural tests. These tests included unrewarded behaviour during open field exploration and a horizontal ladder walking task and reward‐based beam walking and pellet reaching tasks. Infusion of a mix of the antagonists did not impair motor learning in the horizontal ladder walking or the reaching task but reduced spontaneous movement during open field exploration, impaired coordination during beam walking and ladder walking, led to fewer reaches in the pellet reaching task, slowed goal‐directed reaching behaviour and reduced reward pellet consumption in a free access to food task. Infusion of the muscarinic antagonist scopolamine on its own resulted in deficits in motor performance and a reduction in the number of reward pellets consumed in the free access to food task. By contrast, infusion of the nicotinic antagonist mecamylamine on its own had no significant effect on any task, except beam walking traversal time, which was reduced. Together, these data suggest that acetylcholine in the cerebellar interpositus nucleus is important for the execution and coordination of voluntary movements mainly via muscarinic receptor signalling, especially in relation to reward‐related behaviour. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177083194
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        Value: 10.1111/ejn.16066
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      – Code: eng
        Text: English
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        PageCount: 17
        StartPage: 2208
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      – SubjectFull: Cholinergic receptors
        Type: general
      – SubjectFull: Cerebellar nuclei
        Type: general
      – SubjectFull: Tropanes
        Type: general
      – SubjectFull: Motor learning
        Type: general
      – SubjectFull: Cholinergic mechanisms
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      – SubjectFull: Muscarinic receptors
        Type: general
      – SubjectFull: Muscarinic antagonists
        Type: general
      – SubjectFull: Cerebellum
        Type: general
    Titles:
      – TitleFull: Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour.
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            NameFull: Pickford, Jasmine
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            NameFull: Iosif, Cristiana I.
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            NameFull: Bashir, Zafar I.
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            – D: 01
              M: 05
              Text: May2024
              Type: published
              Y: 2024
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