The quality of life impact of the COVID-19 pandemic and lockdowns for people living with multiple sclerosis (MS): evidence from the Australian MS Longitudinal Study.
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| Title: | The quality of life impact of the COVID-19 pandemic and lockdowns for people living with multiple sclerosis (MS): evidence from the Australian MS Longitudinal Study. |
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| Authors: | Henson, Glen J. (AUTHOR), van der Mei, Ingrid (AUTHOR), Taylor, Bruce V. (AUTHOR), Blacklow, Paul (AUTHOR), Claflin, Suzi B. (AUTHOR), Palmer, Andrew J. (AUTHOR), Hurst, Carol (AUTHOR), Campbell, Julie A. (AUTHOR) |
| Source: | Quality of Life Research. Jun2024, Vol. 33 Issue 6, p1675-1689. 15p. |
| Subjects: | Quality of life, Symptoms, Stay-at-home orders, COVID-19 pandemic, Multiple sclerosis |
| Abstract: | Purpose: People living with multiple sclerosis (PwMS) in metropolitan Victoria, Australia, experienced a 112-day, COVID-19-related lockdown in mid-2020. Contemporaneously, Australian PwMS elsewhere experienced minimal restrictions, resulting in a natural experiment. This study investigated the relationships between lockdowns, COVID-19-related adversity, and health-related quality of life (HRQoL). It also generated health state utilities (HSU) representative of changes in HRQoL. Methods: Data were extracted from Australian MS Longitudinal Study surveys, which included the Assessment of Quality of Life-Eight Dimensions (AQoL-8D) instrument and a COVID-19 questionnaire. This COVID-19 questionnaire required participants to rank their COVID-19-related adversity across seven health dimensions. Ordered probits were used to identify variables contributing to adversity. Linear and logit regressions were applied to determine the impact of adversity on HRQoL, defined using AQoL-8D HSUs. Qualitative data were examined thematically. Results: N = 1666 PwMS (average age 58.5; 79.8% female; consistent with the clinical presentation of MS) entered the study, with n = 367 (22.0%) exposed to the 112-day lockdown. Lockdown exposure and disability severity were strongly associated with higher adversity rankings (p < 0.01). Higher adversity rankings were associated with lower HSUs. Participants reporting major adversity, across measured health dimensions, had a mean HSU 0.161 (p < 0.01) lower than participants reporting no adversity and were more likely (OR: 2.716, p < 0.01) to report a clinically significant HSU reduction. Themes in qualitative data supported quantitative findings. Conclusions: We found that COVID-19-related adversity reduced the HRQoL of PwMS. Our HSU estimates can be used in health economic models to evaluate lockdown cost-effectiveness for people with complex and chronic (mainly neurological) diseases. [ABSTRACT FROM AUTHOR] |
| Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 177422262 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The quality of life impact of the COVID-19 pandemic and lockdowns for people living with multiple sclerosis (MS): evidence from the Australian MS Longitudinal Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Henson%2C+Glen+J%2E%22">Henson, Glen J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+der+Mei%2C+Ingrid%22">van der Mei, Ingrid</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taylor%2C+Bruce+V%2E%22">Taylor, Bruce V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blacklow%2C+Paul%22">Blacklow, Paul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Claflin%2C+Suzi+B%2E%22">Claflin, Suzi B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palmer%2C+Andrew+J%2E%22">Palmer, Andrew J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurst%2C+Carol%22">Hurst, Carol</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Campbell%2C+Julie+A%2E%22">Campbell, Julie A.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Jun2024, Vol. 33 Issue 6, p1675-1689. 15p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Stay-at-home+orders%22">Stay-at-home orders</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19+pandemic%22">COVID-19 pandemic</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: People living with multiple sclerosis (PwMS) in metropolitan Victoria, Australia, experienced a 112-day, COVID-19-related lockdown in mid-2020. Contemporaneously, Australian PwMS elsewhere experienced minimal restrictions, resulting in a natural experiment. This study investigated the relationships between lockdowns, COVID-19-related adversity, and health-related quality of life (HRQoL). It also generated health state utilities (HSU) representative of changes in HRQoL. Methods: Data were extracted from Australian MS Longitudinal Study surveys, which included the Assessment of Quality of Life-Eight Dimensions (AQoL-8D) instrument and a COVID-19 questionnaire. This COVID-19 questionnaire required participants to rank their COVID-19-related adversity across seven health dimensions. Ordered probits were used to identify variables contributing to adversity. Linear and logit regressions were applied to determine the impact of adversity on HRQoL, defined using AQoL-8D HSUs. Qualitative data were examined thematically. Results: N = 1666 PwMS (average age 58.5; 79.8% female; consistent with the clinical presentation of MS) entered the study, with n = 367 (22.0%) exposed to the 112-day lockdown. Lockdown exposure and disability severity were strongly associated with higher adversity rankings (p < 0.01). Higher adversity rankings were associated with lower HSUs. Participants reporting major adversity, across measured health dimensions, had a mean HSU 0.161 (p < 0.01) lower than participants reporting no adversity and were more likely (OR: 2.716, p < 0.01) to report a clinically significant HSU reduction. Themes in qualitative data supported quantitative findings. Conclusions: We found that COVID-19-related adversity reduced the HRQoL of PwMS. Our HSU estimates can be used in health economic models to evaluate lockdown cost-effectiveness for people with complex and chronic (mainly neurological) diseases. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177422262 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11136-024-03620-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1675 Subjects: – SubjectFull: Quality of life Type: general – SubjectFull: Symptoms Type: general – SubjectFull: Stay-at-home orders Type: general – SubjectFull: COVID-19 pandemic Type: general – SubjectFull: Multiple sclerosis Type: general Titles: – TitleFull: The quality of life impact of the COVID-19 pandemic and lockdowns for people living with multiple sclerosis (MS): evidence from the Australian MS Longitudinal Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Henson, Glen J. – PersonEntity: Name: NameFull: van der Mei, Ingrid – PersonEntity: Name: NameFull: Taylor, Bruce V. – PersonEntity: Name: NameFull: Blacklow, Paul – PersonEntity: Name: NameFull: Claflin, Suzi B. – PersonEntity: Name: NameFull: Palmer, Andrew J. – PersonEntity: Name: NameFull: Hurst, Carol – PersonEntity: Name: NameFull: Campbell, Julie A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 09629343 Numbering: – Type: volume Value: 33 – Type: issue Value: 6 Titles: – TitleFull: Quality of Life Research Type: main |
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