View in EDS HTML Full Text PDF Full Text

Temporal variations in meibomian gland structure—A pilot study.

Saved in:
Bibliographic Details
Title: Temporal variations in meibomian gland structure—A pilot study.
Authors: Swiderska, Kasandra (AUTHOR), Blackie, Caroline A. (AUTHOR), Maldonado‐Codina, Carole (AUTHOR), Fergie, Martin (AUTHOR), Read, Michael L. (AUTHOR), Morgan, Philip B. (AUTHOR)
Source: Ophthalmic & Physiological Optics. Jul2024, Vol. 44 Issue 5, p894-909. 16p.
Subjects: Meibomian glands, Pilot projects, Glands, Tortuosity
Abstract: Purpose: To investigate whether there is a measurable change in meibomian gland morphological characteristics over the course of a day (12 h) and over a month. Methods: The study enrolled 15 participants who attended a total of 11 study visits spanning a 5‐week period. To assess diurnal changes in meibomian glands, seven visits were conducted on a single day, each 2 h apart. For monthly assessment, participants attended an additional visit at the same time of the day every week for three consecutive weeks. Meibography using the LipiView® II system was performed at each visit, and meibomian gland morphological parameters were calculated using custom semi‐automated software. Specifically, six central glands were analysed for gland length ratio, gland width, gland area, gland intensity and gland tortuosity. Results: The average meibomian gland morphological metrics did not exhibit significant changes during the course of a day or over a month. Nonetheless, certain individual gland metrics demonstrated notable variation over time, both diurnally and monthly. Specifically, meibomian gland length ratio, area, width and tortuosity exhibited significant changes both diurnally and monthly when assessed on a gland‐by‐gland basis. Conclusions: Meibomian glands demonstrated measurable structural change over short periods of time (hours and days). These results have implications for innovation in gland imaging and for developing precision monitoring of gland structure to assess meibomian gland health more accurately. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 177772536
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Temporal variations in meibomian gland structure—A pilot study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Swiderska%2C+Kasandra%22">Swiderska, Kasandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blackie%2C+Caroline+A%2E%22">Blackie, Caroline A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maldonado‐Codina%2C+Carole%22">Maldonado‐Codina, Carole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fergie%2C+Martin%22">Fergie, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Read%2C+Michael+L%2E%22">Read, Michael L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morgan%2C+Philip+B%2E%22">Morgan, Philip B.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Ophthalmic+%26+Physiological+Optics%22">Ophthalmic & Physiological Optics</searchLink>. Jul2024, Vol. 44 Issue 5, p894-909. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Meibomian+glands%22">Meibomian glands</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Glands%22">Glands</searchLink><br /><searchLink fieldCode="DE" term="%22Tortuosity%22">Tortuosity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To investigate whether there is a measurable change in meibomian gland morphological characteristics over the course of a day (12 h) and over a month. Methods: The study enrolled 15 participants who attended a total of 11 study visits spanning a 5‐week period. To assess diurnal changes in meibomian glands, seven visits were conducted on a single day, each 2 h apart. For monthly assessment, participants attended an additional visit at the same time of the day every week for three consecutive weeks. Meibography using the LipiView® II system was performed at each visit, and meibomian gland morphological parameters were calculated using custom semi‐automated software. Specifically, six central glands were analysed for gland length ratio, gland width, gland area, gland intensity and gland tortuosity. Results: The average meibomian gland morphological metrics did not exhibit significant changes during the course of a day or over a month. Nonetheless, certain individual gland metrics demonstrated notable variation over time, both diurnally and monthly. Specifically, meibomian gland length ratio, area, width and tortuosity exhibited significant changes both diurnally and monthly when assessed on a gland‐by‐gland basis. Conclusions: Meibomian glands demonstrated measurable structural change over short periods of time (hours and days). These results have implications for innovation in gland imaging and for developing precision monitoring of gland structure to assess meibomian gland health more accurately. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177772536
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/opo.13321
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 894
    Subjects:
      – SubjectFull: Meibomian glands
        Type: general
      – SubjectFull: Pilot projects
        Type: general
      – SubjectFull: Glands
        Type: general
      – SubjectFull: Tortuosity
        Type: general
    Titles:
      – TitleFull: Temporal variations in meibomian gland structure—A pilot study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Swiderska, Kasandra
      – PersonEntity:
          Name:
            NameFull: Blackie, Caroline A.
      – PersonEntity:
          Name:
            NameFull: Maldonado‐Codina, Carole
      – PersonEntity:
          Name:
            NameFull: Fergie, Martin
      – PersonEntity:
          Name:
            NameFull: Read, Michael L.
      – PersonEntity:
          Name:
            NameFull: Morgan, Philip B.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 02755408
          Numbering:
            – Type: volume
              Value: 44
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Ophthalmic & Physiological Optics
              Type: main
ResultId 1