Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes.
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| Title: | Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes. |
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| Authors: | Shakhatreh, Lubna (AUTHOR), Sinclair, Ben (AUTHOR), McLean, Catriona (AUTHOR), Lui, Elaine (AUTHOR), Morokoff, Andrew P. (AUTHOR), King, James A. (AUTHOR), Chen, Zhibin (AUTHOR), Perucca, Piero (AUTHOR), O'Brien, Terence J. (AUTHOR), Kwan, Patrick (AUTHOR) |
| Source: | Epilepsia (Series 4). Jun2024, Vol. 65 Issue 6, p1709-1719. 11p. |
| Subjects: | Temporal lobectomy, Temporal lobe epilepsy, Amygdaloid body, Magnetic resonance imaging, Mann Whitney U Test, Temporal lobe |
| Abstract: | Objectives: Amygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug‐resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygdala enlargement (1) predicted seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL‐AH) and (2) was associated with specific histopathological changes. Methods: This was a case–control study. We included patients with drug‐resistant TLE who underwent ATL‐AH with and without amygdala enlargement detected on pre‐operative MRI. Amygdala volumetry was done using FreeSurfer for patients who had high‐resolution T1‐weighted images. Mann–Whitney U test was used to compare pre‐operative clinical characteristics between the two groups. The amygdala volume on the epileptogenic side was compared to the amygdala volume on the contralateral side among cases and controls. Then, we used a two‐sample, independent t test to compare the means of amygdala volume differences between cases and controls. The chi‐square test was used to assess the correlation of amygdala enlargement with (1) post‐surgical seizure outcomes and (2) histopathological changes. Results: Nineteen patients with and 19 patients without amygdala enlargement were studied. Their median age at surgery was 38 years for cases and 39 years for controls, and 52.6% were male. There were no statistically significant differences between the two groups in their pre‐operative clinical characteristics. There were significant differences in the means of volume difference between cases and controls (Diff = 457.2 mm3, 95% confidence interval [CI] 289.6–624.8; p <.001) and in the means of percentage difference (p <.001). However, there was no significant association between amygdala enlargement and surgical outcome (p =.72) or histopathological changes (p =.63). Significance: The presence of amygdala enlargement on the pre‐operative brain MRI in patients with TLE does not affect the surgical outcome following ATL‐AH, and it does not necessarily suggest abnormal histopathology. These findings suggest that amygdala enlargement might reflect a secondary reactive process to seizures in the epileptogenic temporal lobe. [ABSTRACT FROM AUTHOR] |
| Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 177798092 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shakhatreh%2C+Lubna%22">Shakhatreh, Lubna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sinclair%2C+Ben%22">Sinclair, Ben</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McLean%2C+Catriona%22">McLean, Catriona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lui%2C+Elaine%22">Lui, Elaine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morokoff%2C+Andrew+P%2E%22">Morokoff, Andrew P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22King%2C+James+A%2E%22">King, James A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Zhibin%22">Chen, Zhibin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perucca%2C+Piero%22">Perucca, Piero</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22O'Brien%2C+Terence+J%2E%22">O'Brien, Terence J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwan%2C+Patrick%22">Kwan, Patrick</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jun2024, Vol. 65 Issue 6, p1709-1719. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Temporal+lobectomy%22">Temporal lobectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe+epilepsy%22">Temporal lobe epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: Amygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug‐resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygdala enlargement (1) predicted seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL‐AH) and (2) was associated with specific histopathological changes. Methods: This was a case–control study. We included patients with drug‐resistant TLE who underwent ATL‐AH with and without amygdala enlargement detected on pre‐operative MRI. Amygdala volumetry was done using FreeSurfer for patients who had high‐resolution T1‐weighted images. Mann–Whitney U test was used to compare pre‐operative clinical characteristics between the two groups. The amygdala volume on the epileptogenic side was compared to the amygdala volume on the contralateral side among cases and controls. Then, we used a two‐sample, independent t test to compare the means of amygdala volume differences between cases and controls. The chi‐square test was used to assess the correlation of amygdala enlargement with (1) post‐surgical seizure outcomes and (2) histopathological changes. Results: Nineteen patients with and 19 patients without amygdala enlargement were studied. Their median age at surgery was 38 years for cases and 39 years for controls, and 52.6% were male. There were no statistically significant differences between the two groups in their pre‐operative clinical characteristics. There were significant differences in the means of volume difference between cases and controls (Diff = 457.2 mm3, 95% confidence interval [CI] 289.6–624.8; p <.001) and in the means of percentage difference (p <.001). However, there was no significant association between amygdala enlargement and surgical outcome (p =.72) or histopathological changes (p =.63). Significance: The presence of amygdala enlargement on the pre‐operative brain MRI in patients with TLE does not affect the surgical outcome following ATL‐AH, and it does not necessarily suggest abnormal histopathology. These findings suggest that amygdala enlargement might reflect a secondary reactive process to seizures in the epileptogenic temporal lobe. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177798092 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/epi.17968 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1709 Subjects: – SubjectFull: Temporal lobectomy Type: general – SubjectFull: Temporal lobe epilepsy Type: general – SubjectFull: Amygdaloid body Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Mann Whitney U Test Type: general – SubjectFull: Temporal lobe Type: general Titles: – TitleFull: Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shakhatreh, Lubna – PersonEntity: Name: NameFull: Sinclair, Ben – PersonEntity: Name: NameFull: McLean, Catriona – PersonEntity: Name: NameFull: Lui, Elaine – PersonEntity: Name: NameFull: Morokoff, Andrew P. – PersonEntity: Name: NameFull: King, James A. – PersonEntity: Name: NameFull: Chen, Zhibin – PersonEntity: Name: NameFull: Perucca, Piero – PersonEntity: Name: NameFull: O'Brien, Terence J. – PersonEntity: Name: NameFull: Kwan, Patrick IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00139580 Numbering: – Type: volume Value: 65 – Type: issue Value: 6 Titles: – TitleFull: Epilepsia (Series 4) Type: main |
| ResultId | 1 |
