View in EDS HTML Full Text PDF Full Text

Coma in adult cerebral venous thrombosis: The BEAST study.

Saved in:
Bibliographic Details
Title: Coma in adult cerebral venous thrombosis: The BEAST study.
Authors: Ranjan, Redoy (AUTHOR), Ken‐Dror, Gie (AUTHOR), Martinelli, Ida (AUTHOR), Grandone, Elvira (AUTHOR), Hiltunen, Sini (AUTHOR), Lindgren, Erik (AUTHOR), Margaglione, Maurizio (AUTHOR), Duchez, Veronique Le Cam (AUTHOR), Triquenot Bagan, Aude (AUTHOR), Zedde, Marialuisa (AUTHOR), Giannini, Nicola (AUTHOR), Ruigrok, Ynte M. (AUTHOR), Worrall, Bradford B. (AUTHOR), Majersik, Jennifer J. (AUTHOR), Putaala, Jukka (AUTHOR), Haapaniemi, Elena (AUTHOR), Zuurbier, Susanna M. (AUTHOR), Brouwer, Matthijs C. (AUTHOR), Passamonti, Serena M. (AUTHOR), Abbattista, Maria (AUTHOR)
Source: European Journal of Neurology. Aug2024, Vol. 31 Issue 8, p1-6. 6p.
Subjects: Cerebral embolism & thrombosis, Venous thrombosis, Receiver operating characteristic curves, Coma, Sinus thrombosis
Abstract: Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female‐predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5–60) versus 40 (33–47) years in the coma (p = 0.04) and 44.5 (34–58) versus 37 (29–48) years in the non‐coma sample (p < 0.001), respectively. Furthermore, an age‐ and superior sagittal sinus‐adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0–3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52–0.68, p = 0.01). Conclusions: Although CVT is a female‐predominant disease, men were older and nearly twice as likely to suffer from coma than women. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 178297429
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Coma in adult cerebral venous thrombosis: The BEAST study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ranjan%2C+Redoy%22&quot;&gt;Ranjan, Redoy&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ken‐Dror%2C+Gie%22&quot;&gt;Ken‐Dror, Gie&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Martinelli%2C+Ida%22&quot;&gt;Martinelli, Ida&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Grandone%2C+Elvira%22&quot;&gt;Grandone, Elvira&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hiltunen%2C+Sini%22&quot;&gt;Hiltunen, Sini&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lindgren%2C+Erik%22&quot;&gt;Lindgren, Erik&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Margaglione%2C+Maurizio%22&quot;&gt;Margaglione, Maurizio&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Duchez%2C+Veronique+Le+Cam%22&quot;&gt;Duchez, Veronique Le Cam&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Triquenot&#160;Bagan%2C+Aude%22&quot;&gt;Triquenot&#160;Bagan, Aude&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zedde%2C+Marialuisa%22&quot;&gt;Zedde, Marialuisa&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giannini%2C+Nicola%22&quot;&gt;Giannini, Nicola&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ruigrok%2C+Ynte+M%2E%22&quot;&gt;Ruigrok, Ynte M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Worrall%2C+Bradford+B%2E%22&quot;&gt;Worrall, Bradford B.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Majersik%2C+Jennifer+J%2E%22&quot;&gt;Majersik, Jennifer J.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Putaala%2C+Jukka%22&quot;&gt;Putaala, Jukka&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Haapaniemi%2C+Elena%22&quot;&gt;Haapaniemi, Elena&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zuurbier%2C+Susanna+M%2E%22&quot;&gt;Zuurbier, Susanna M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brouwer%2C+Matthijs+C%2E%22&quot;&gt;Brouwer, Matthijs C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Passamonti%2C+Serena+M%2E%22&quot;&gt;Passamonti, Serena M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Abbattista%2C+Maria%22&quot;&gt;Abbattista, Maria&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Aug2024, Vol. 31 Issue 8, p1-6. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cerebral+embolism+%26+thrombosis%22&quot;&gt;Cerebral embolism &amp; thrombosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Venous+thrombosis%22&quot;&gt;Venous thrombosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Receiver+operating+characteristic+curves%22&quot;&gt;Receiver operating characteristic curves&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coma%22&quot;&gt;Coma&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sinus+thrombosis%22&quot;&gt;Sinus thrombosis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with &lt;10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female‐predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p &lt; 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5–60) versus 40 (33–47) years in the coma (p = 0.04) and 44.5 (34–58) versus 37 (29–48) years in the non‐coma sample (p &lt; 0.001), respectively. Furthermore, an age‐ and superior sagittal sinus‐adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0–3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52–0.68, p = 0.01). Conclusions: Although CVT is a female‐predominant disease, men were older and nearly twice as likely to suffer from coma than women. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=178297429
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.16311
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1
    Subjects:
      – SubjectFull: Cerebral embolism & thrombosis
        Type: general
      – SubjectFull: Venous thrombosis
        Type: general
      – SubjectFull: Receiver operating characteristic curves
        Type: general
      – SubjectFull: Coma
        Type: general
      – SubjectFull: Sinus thrombosis
        Type: general
    Titles:
      – TitleFull: Coma in adult cerebral venous thrombosis: The BEAST study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ranjan, Redoy
      – PersonEntity:
          Name:
            NameFull: Ken‐Dror, Gie
      – PersonEntity:
          Name:
            NameFull: Martinelli, Ida
      – PersonEntity:
          Name:
            NameFull: Grandone, Elvira
      – PersonEntity:
          Name:
            NameFull: Hiltunen, Sini
      – PersonEntity:
          Name:
            NameFull: Lindgren, Erik
      – PersonEntity:
          Name:
            NameFull: Margaglione, Maurizio
      – PersonEntity:
          Name:
            NameFull: Duchez, Veronique Le Cam
      – PersonEntity:
          Name:
            NameFull: Triquenot Bagan, Aude
      – PersonEntity:
          Name:
            NameFull: Zedde, Marialuisa
      – PersonEntity:
          Name:
            NameFull: Giannini, Nicola
      – PersonEntity:
          Name:
            NameFull: Ruigrok, Ynte M.
      – PersonEntity:
          Name:
            NameFull: Worrall, Bradford B.
      – PersonEntity:
          Name:
            NameFull: Majersik, Jennifer J.
      – PersonEntity:
          Name:
            NameFull: Putaala, Jukka
      – PersonEntity:
          Name:
            NameFull: Haapaniemi, Elena
      – PersonEntity:
          Name:
            NameFull: Zuurbier, Susanna M.
      – PersonEntity:
          Name:
            NameFull: Brouwer, Matthijs C.
      – PersonEntity:
          Name:
            NameFull: Passamonti, Serena M.
      – PersonEntity:
          Name:
            NameFull: Abbattista, Maria
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 31
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1