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Multivariate sharp‐wave ripples in schizophrenia during awake state.

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Title: Multivariate sharp‐wave ripples in schizophrenia during awake state.
Authors: Ohki, Takefumi (AUTHOR), Chao, Zenas C. (AUTHOR), Takei, Yuichi (AUTHOR), Kato, Yutaka (AUTHOR), Sunaga, Masakazu (AUTHOR), Suto, Tomohiro (AUTHOR), Tagawa, Minami (AUTHOR), Fukuda, Masato (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Sep2024, Vol. 78 Issue 9, p507-516. 10p.
Subjects: Cognition disorders, Multivariate analysis, Psychoses, Symptoms, Neurological disorders
Abstract: Aims: Schizophrenia (SZ) is a brain disorder characterized by psychotic symptoms and cognitive dysfunction. Recently, irregularities in sharp‐wave ripples (SPW‐Rs) have been reported in SZ. As SPW‐Rs play a critical role in memory, their irregularities can cause psychotic symptoms and cognitive dysfunction in patients with SZ. In this study, we investigated the SPW‐Rs in human SZ. Methods: We measured whole‐brain activity using magnetoencephalography (MEG) in patients with SZ (n = 20) and sex‐ and age‐matched healthy participants (n = 20) during open‐eye rest. We identified SPW‐Rs and analyzed their occurrence and time‐frequency traits. Furthermore, we developed a novel multivariate analysis method, termed "ripple‐gedMEG" to extract the global features of SPW‐Rs. We also examined the association between SPW‐Rs and brain state transitions. The outcomes of these analyses were modeled to predict the positive and negative syndrome scale (PANSS) scores of SZ. Results: We found that SPW‐Rs in the SZ (1) occurred more frequently, (2) the delay of the coupling phase (3) appeared in different brain areas, (4) consisted of a less organized spatiotemporal pattern, and (5) were less involved in brain state transitions. Finally, some of the neural features associated with the SPW‐Rs were found to be PANSS‐positive, a pathological indicator of SZ. These results suggest that widespread but disorganized SPW‐Rs underlies the symptoms of SZ. Conclusion: We identified irregularities in SPW‐Rs in SZ and confirmed that their alternations were strongly associated with SZ neuropathology. These results suggest a new direction for human SZ research. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Multivariate sharp‐wave ripples in schizophrenia during awake state.
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  Data: <searchLink fieldCode="AR" term="%22Ohki%2C+Takefumi%22">Ohki, Takefumi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chao%2C+Zenas+C%2E%22">Chao, Zenas C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Takei%2C+Yuichi%22">Takei, Yuichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kato%2C+Yutaka%22">Kato, Yutaka</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sunaga%2C+Masakazu%22">Sunaga, Masakazu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Suto%2C+Tomohiro%22">Suto, Tomohiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tagawa%2C+Minami%22">Tagawa, Minami</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fukuda%2C+Masato%22">Fukuda, Masato</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Sep2024, Vol. 78 Issue 9, p507-516. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink>
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  Label: Abstract
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  Data: Aims: Schizophrenia (SZ) is a brain disorder characterized by psychotic symptoms and cognitive dysfunction. Recently, irregularities in sharp‐wave ripples (SPW‐Rs) have been reported in SZ. As SPW‐Rs play a critical role in memory, their irregularities can cause psychotic symptoms and cognitive dysfunction in patients with SZ. In this study, we investigated the SPW‐Rs in human SZ. Methods: We measured whole‐brain activity using magnetoencephalography (MEG) in patients with SZ (n = 20) and sex‐ and age‐matched healthy participants (n = 20) during open‐eye rest. We identified SPW‐Rs and analyzed their occurrence and time‐frequency traits. Furthermore, we developed a novel multivariate analysis method, termed "ripple‐gedMEG" to extract the global features of SPW‐Rs. We also examined the association between SPW‐Rs and brain state transitions. The outcomes of these analyses were modeled to predict the positive and negative syndrome scale (PANSS) scores of SZ. Results: We found that SPW‐Rs in the SZ (1) occurred more frequently, (2) the delay of the coupling phase (3) appeared in different brain areas, (4) consisted of a less organized spatiotemporal pattern, and (5) were less involved in brain state transitions. Finally, some of the neural features associated with the SPW‐Rs were found to be PANSS‐positive, a pathological indicator of SZ. These results suggest that widespread but disorganized SPW‐Rs underlies the symptoms of SZ. Conclusion: We identified irregularities in SPW‐Rs in SZ and confirmed that their alternations were strongly associated with SZ neuropathology. These results suggest a new direction for human SZ research. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Multivariate sharp‐wave ripples in schizophrenia during awake state.
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              Text: Sep2024
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