Subcutaneous immunoglobulins (SCIG) for chronic inflammatory demyelinating polyneuropathy (CIDP): A comprehensive systematic review of clinical studies and meta-analysis.
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| Title: | Subcutaneous immunoglobulins (SCIG) for chronic inflammatory demyelinating polyneuropathy (CIDP): A comprehensive systematic review of clinical studies and meta-analysis. |
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| Authors: | Ramzi, Ahmed (AUTHOR), Maya, Subhia (AUTHOR), Balousha, Nadeen (AUTHOR), Sabet, Haneen (AUTHOR), Samir, Ahmed (AUTHOR), Roshdy, Merna Raafat (AUTHOR), Aljarrah, Ghalia (AUTHOR), Saleh, Sireen (AUTHOR), Kertam, Ahmed (AUTHOR), Serag, Ibrahim (AUTHOR), Shiha, Mostafa Ramzi (AUTHOR) |
| Source: | Neurological Sciences. Nov2024, Vol. 45 Issue 11, p5213-5230. 18p. |
| Subjects: | Chronic inflammatory demyelinating polyradiculoneuropathy, Patient experience, Patient preferences, Patients' attitudes, Muscle strength |
| Abstract: | Background: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) presents significant treatment challenges due to its chronic nature, varied clinical presentations, and rarity. Subcutaneous immunoglobulin (SCIG) has emerged as a maintenance therapy, offering potential advantages in administration and patient experience over the previously recognized intravenous immunoglobulin (IVIG). Methods: We included all clinical studies involving CIDP patients treated with SCIG from eleven databases up to March 2024. Results: 50 clinical studies were included in the systematic review, with 22 involved in the meta-analysis. These studies offer clinical data on around 1400 CIDP patients. Almost all studies considered SCIG a maintenance therapy, with the majority of results suggesting it as a viable substitute that may offer comparable or enhanced advantages. Studies covered aspects such as efficacy, safety, quality of life, practicality, economic evaluation, and patient preference. Meta-analysis showed SCIG significantly improved muscle strength and sensory function, had fewer and milder side effects, reduced relapse rates, and received a strong preference. Conclusions: Findings suggest that SCIG for CIDP maintenance not only provides a more feasible alternative, with economic evaluations showing considerable cost reductions over time, and patient preference for SCIG being pronounced, but may also deliver comparable or superior health outcomes. Ongoing research lines on formulations, techniques, and direct comparative studies are critical to further illuminate, enhance, and expand SCIG's role in treatment. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 180235776 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Subcutaneous immunoglobulins (SCIG) for chronic inflammatory demyelinating polyneuropathy (CIDP): A comprehensive systematic review of clinical studies and meta-analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ramzi%2C+Ahmed%22">Ramzi, Ahmed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maya%2C+Subhia%22">Maya, Subhia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balousha%2C+Nadeen%22">Balousha, Nadeen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sabet%2C+Haneen%22">Sabet, Haneen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Samir%2C+Ahmed%22">Samir, Ahmed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roshdy%2C+Merna+Raafat%22">Roshdy, Merna Raafat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aljarrah%2C+Ghalia%22">Aljarrah, Ghalia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saleh%2C+Sireen%22">Saleh, Sireen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kertam%2C+Ahmed%22">Kertam, Ahmed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serag%2C+Ibrahim%22">Serag, Ibrahim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shiha%2C+Mostafa+Ramzi%22">Shiha, Mostafa Ramzi</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Nov2024, Vol. 45 Issue 11, p5213-5230. 18p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Chronic+inflammatory+demyelinating+polyradiculoneuropathy%22">Chronic inflammatory demyelinating polyradiculoneuropathy</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+experience%22">Patient experience</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+preferences%22">Patient preferences</searchLink><br /><searchLink fieldCode="DE" term="%22Patients'+attitudes%22">Patients' attitudes</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+strength%22">Muscle strength</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) presents significant treatment challenges due to its chronic nature, varied clinical presentations, and rarity. Subcutaneous immunoglobulin (SCIG) has emerged as a maintenance therapy, offering potential advantages in administration and patient experience over the previously recognized intravenous immunoglobulin (IVIG). Methods: We included all clinical studies involving CIDP patients treated with SCIG from eleven databases up to March 2024. Results: 50 clinical studies were included in the systematic review, with 22 involved in the meta-analysis. These studies offer clinical data on around 1400 CIDP patients. Almost all studies considered SCIG a maintenance therapy, with the majority of results suggesting it as a viable substitute that may offer comparable or enhanced advantages. Studies covered aspects such as efficacy, safety, quality of life, practicality, economic evaluation, and patient preference. Meta-analysis showed SCIG significantly improved muscle strength and sensory function, had fewer and milder side effects, reduced relapse rates, and received a strong preference. Conclusions: Findings suggest that SCIG for CIDP maintenance not only provides a more feasible alternative, with economic evaluations showing considerable cost reductions over time, and patient preference for SCIG being pronounced, but may also deliver comparable or superior health outcomes. Ongoing research lines on formulations, techniques, and direct comparative studies are critical to further illuminate, enhance, and expand SCIG's role in treatment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-024-07640-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 5213 Subjects: – SubjectFull: Chronic inflammatory demyelinating polyradiculoneuropathy Type: general – SubjectFull: Patient experience Type: general – SubjectFull: Patient preferences Type: general – SubjectFull: Patients' attitudes Type: general – SubjectFull: Muscle strength Type: general Titles: – TitleFull: Subcutaneous immunoglobulins (SCIG) for chronic inflammatory demyelinating polyneuropathy (CIDP): A comprehensive systematic review of clinical studies and meta-analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ramzi, Ahmed – PersonEntity: Name: NameFull: Maya, Subhia – PersonEntity: Name: NameFull: Balousha, Nadeen – PersonEntity: Name: NameFull: Sabet, Haneen – PersonEntity: Name: NameFull: Samir, Ahmed – PersonEntity: Name: NameFull: Roshdy, Merna Raafat – PersonEntity: Name: NameFull: Aljarrah, Ghalia – PersonEntity: Name: NameFull: Saleh, Sireen – PersonEntity: Name: NameFull: Kertam, Ahmed – PersonEntity: Name: NameFull: Serag, Ibrahim – PersonEntity: Name: NameFull: Shiha, Mostafa Ramzi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 45 – Type: issue Value: 11 Titles: – TitleFull: Neurological Sciences Type: main |
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