Development of a dry eye index as a new biomarker of dry eye disease.
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| Title: | Development of a dry eye index as a new biomarker of dry eye disease. |
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| Authors: | Gala‐Núñez, César (AUTHOR), Ortiz‐Peregrina, Sonia (AUTHOR), Castanera‐Gratacós, Diego (AUTHOR), Anera, Rosario G. (AUTHOR) |
| Source: | Ophthalmic & Physiological Optics. Nov2024, Vol. 44 Issue 7, p1472-1483. 12p. |
| Subjects: | Dry eye syndromes, Contrast sensitivity (Vision), Meibomian glands, Visual acuity, Symptoms |
| Abstract: | Purpose: To evaluate signs and symptoms in patients diagnosed with dry eye disease (DED), divided into dry eye (DE) groups, in order to find a new biomarker that allows an accurate diagnosis, management and classification of DED. Methods: This cross‐sectional, observational study included 71 DED subjects. Subjective symptoms, visual quality and DE signs were assessed using the Ocular Surface Disease Index (OSDI), the Quality of Vision (QoV) questionnaire, best corrected distance visual acuity (VA), functional visual acuity (FVA), contrast sensitivity (CS), high‐ and low‐order corneal aberrations (HOA and LOA, respectively), tear break‐up time (TBUT), Meibomian Gland Dysfunction (MGD), Schirmer test, corneal staining, lid wiper epitheliopathy (LWE) and meibography. Participants were classified into three groups based on dryness severity using a cluster analysis, i.e., mild (N = 17, 55.8 ± 15.4 years), moderate (N = 41, 63.5 ± 10.6 years) and severe (N = 13, 65.0 ± 12.0). A new Dry Eye Severity Index (DESI) based on ocular surface signs has been developed and its association with symptoms, visual quality and signs was assessed. Comparisons between groups were made using Kruskal–Wallis and Chi‐squared tests. Spearman correlation analysis was also performed. Results: The DESI was based on three tests for DE signs: TBUT, Schirmer test and MGD. The DESI showed significant differences between different pairs of groups: Mild Dryness versus Moderate Dryness (p < 0.001), Mild Dryness versus Severe Dryness (p < 0.001) and Moderate Dryness versus Severe Dryness (p < 0.001). The DESI was significantly correlated with age (rho = −0.30; p = 0.01), OSDI score (rho = −0.32; p = 0.007), QoV score (rho = −0.35; p = 0.003), VA (rho = −0.34; p = 0.003), FVA (rho = −0.38; p = 0.001) and CS (rho = 0.42; p < 0.001) Also, significant differences between the severity groups were found for OSDI and QoV scores, VA, FVA, CS and MGD (p < 0.05). Conclusions: The DESI has good performance as a biomarker for the diagnosis, classification and management of DED. [ABSTRACT FROM AUTHOR] |
| Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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