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Localisation of eloquent cortex using magnetoencephalography and its clinical implications.

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Title: Localisation of eloquent cortex using magnetoencephalography and its clinical implications.
Authors: Mishra, Rakesh (AUTHOR), Mariyappa, N (AUTHOR), Rao Malla, Bhaskara (AUTHOR), Arivazhagan, A (AUTHOR), Mishra, Bhupendra (AUTHOR), Gautham, Bhargava (AUTHOR), Chowdary Mundlamuri, Ravindranadh (AUTHOR), Jayabal, Velmurugan (AUTHOR), Raghavendra, Kenchaiah (AUTHOR), Asranna, Ajay (AUTHOR), Viswanathan, L. G. (AUTHOR), Sadashiva, Nishanth (AUTHOR), Bharath, Rose Dawn (AUTHOR), Saini, Jitender (AUTHOR), Nagaraj, Chandana (AUTHOR), Mangalore, Sandhya (AUTHOR), Karthik, Kulanthaivelu (AUTHOR), Rajeswaran, Jamuna (AUTHOR), Kumar, Keshav (AUTHOR), Mahadevan, Anita (AUTHOR)
Source: International Journal of Neuroscience. Dec2024, Vol. 134 Issue 12, p1490-1502. 13p.
Subjects: People with epilepsy, Frontal lobe, Epilepsy surgery, Temporal lobe, Magnetic fields
Abstract: Objectives: This study aimed to localise the eloquent cortex and measure evoked field (EF) parameters using magnetoencephalography in patients with epilepsy and tumours near the eloquent cortex. Methods: A total of 41 patients (26 with drug-refractory epilepsy and 15 with tumours), with a mean age of 33 years, were recruited. Visual evoked field (VEF), auditory evoked field (AEF), sensory evoked field (SSEF), and motor-evoked field (MEF) latencies, amplitudes, and localisation were compared with those of a control population. Subgroup analyses were performed based on lobar involvement. Evoked Field parameters on the affected side were compared with those on the opposite side. The effect of distance from the lesion on nearby and distant evoked fields was evaluated. Results: AEF and VEF amplitudes and latencies were reduced bilaterally (p < 0.05). Amplitude in the ipsilateral SSEF was reduced by 29.27% and 2.16% in the AEF group compared to the contralateral side (p = 0.02). In patients with temporal lobe lesions, the SSEF amplitude was reduced bilaterally (p < 0.02), and latency was prolonged compared with controls. The MEF amplitude was reduced and latency was prolonged in patients with frontal lobe lesions (p = 0.01). EF displacement was 32%, 57%, 21%, and 16% for AEF, MEF, VEF, and SSEF respectively. Patients in the epilepsy group had distant EF abnormalities. Conclusions: EF amplitude was reduced and latency was prolonged in the involved hemisphere. Distant EF amplitudes were more affected than latencies in epilepsy. Amplitude and distance from the lesion had negative correlation for all EF. EF changes indicated eloquent cortical displacement which may not be apparent on MRI. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Localisation of eloquent cortex using magnetoencephalography and its clinical implications.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mishra%2C+Rakesh%22&quot;&gt;Mishra, Rakesh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mariyappa%2C+N%22&quot;&gt;Mariyappa, N&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rao+Malla%2C+Bhaskara%22&quot;&gt;Rao Malla, Bhaskara&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arivazhagan%2C+A%22&quot;&gt;Arivazhagan, A&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mishra%2C+Bhupendra%22&quot;&gt;Mishra, Bhupendra&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gautham%2C+Bhargava%22&quot;&gt;Gautham, Bhargava&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chowdary+Mundlamuri%2C+Ravindranadh%22&quot;&gt;Chowdary Mundlamuri, Ravindranadh&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jayabal%2C+Velmurugan%22&quot;&gt;Jayabal, Velmurugan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Raghavendra%2C+Kenchaiah%22&quot;&gt;Raghavendra, Kenchaiah&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Asranna%2C+Ajay%22&quot;&gt;Asranna, Ajay&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Viswanathan%2C+L%2E+G%2E%22&quot;&gt;Viswanathan, L. G.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sadashiva%2C+Nishanth%22&quot;&gt;Sadashiva, Nishanth&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bharath%2C+Rose+Dawn%22&quot;&gt;Bharath, Rose Dawn&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saini%2C+Jitender%22&quot;&gt;Saini, Jitender&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nagaraj%2C+Chandana%22&quot;&gt;Nagaraj, Chandana&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mangalore%2C+Sandhya%22&quot;&gt;Mangalore, Sandhya&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Karthik%2C+Kulanthaivelu%22&quot;&gt;Karthik, Kulanthaivelu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rajeswaran%2C+Jamuna%22&quot;&gt;Rajeswaran, Jamuna&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kumar%2C+Keshav%22&quot;&gt;Kumar, Keshav&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mahadevan%2C+Anita%22&quot;&gt;Mahadevan, Anita&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Neuroscience%22&quot;&gt;International Journal of Neuroscience&lt;/searchLink&gt;. Dec2024, Vol. 134 Issue 12, p1490-1502. 13p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22People+with+epilepsy%22&quot;&gt;People with epilepsy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Frontal+lobe%22&quot;&gt;Frontal lobe&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Epilepsy+surgery%22&quot;&gt;Epilepsy surgery&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Temporal+lobe%22&quot;&gt;Temporal lobe&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+fields%22&quot;&gt;Magnetic fields&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: This study aimed to localise the eloquent cortex and measure evoked field (EF) parameters using magnetoencephalography in patients with epilepsy and tumours near the eloquent cortex. Methods: A total of 41 patients (26 with drug-refractory epilepsy and 15 with tumours), with a mean age of 33 years, were recruited. Visual evoked field (VEF), auditory evoked field (AEF), sensory evoked field (SSEF), and motor-evoked field (MEF) latencies, amplitudes, and localisation were compared with those of a control population. Subgroup analyses were performed based on lobar involvement. Evoked Field parameters on the affected side were compared with those on the opposite side. The effect of distance from the lesion on nearby and distant evoked fields was evaluated. Results: AEF and VEF amplitudes and latencies were reduced bilaterally (p &lt; 0.05). Amplitude in the ipsilateral SSEF was reduced by 29.27% and 2.16% in the AEF group compared to the contralateral side (p = 0.02). In patients with temporal lobe lesions, the SSEF amplitude was reduced bilaterally (p &lt; 0.02), and latency was prolonged compared with controls. The MEF amplitude was reduced and latency was prolonged in patients with frontal lobe lesions (p = 0.01). EF displacement was 32%, 57%, 21%, and 16% for AEF, MEF, VEF, and SSEF respectively. Patients in the epilepsy group had distant EF abnormalities. Conclusions: EF amplitude was reduced and latency was prolonged in the involved hemisphere. Distant EF amplitudes were more affected than latencies in epilepsy. Amplitude and distance from the lesion had negative correlation for all EF. EF changes indicated eloquent cortical displacement which may not be apparent on MRI. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of International Journal of Neuroscience is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1080/00207454.2023.2270684
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