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Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.

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Title: Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.
Authors: Devigili, G. (AUTHOR), Di Stefano, G. (AUTHOR), Donadio, V. (AUTHOR), Frattale, I. (AUTHOR), Grazzi, L. (AUTHOR), Mantovani, E. (AUTHOR), Nolano, M. (AUTHOR), Provitera, V. (AUTHOR), Quitadamo, S. G. (AUTHOR), Tamburin, S. (AUTHOR), Truini, A. (AUTHOR), Valeriani, M. (AUTHOR), Furia, A. (AUTHOR), Vecchio, E. (AUTHOR), Fischetti, F. (AUTHOR), Greco, G. (AUTHOR), Telesca, A. (AUTHOR), de Tommaso, M. (AUTHOR)
Source: Neurological Sciences. May2025, Vol. 46 Issue 5, p2263-2288. 26p.
Subjects: Medical sciences, Cognitive therapy, Therapeutics, Aerobic exercises, Brain stimulation
Abstract: Background: Although fibromyalgia is a disabling disease, there is no targeted therapy for specific neurotransmitters or inflammatory mediators. Our aim was to provide neurologists with practical guidance for the management of these difficult patients based on a critical, narrative and non-systematic review of randomized controlled trials (RCTs) from the last 10 years. Methods: The members of the Special Interest Group Neuropathic Pain of the Italian Neurological Society evaluated the randomized controlled trials (RCTs) of the last 10 years and answered questions that allow a consensus on the main pharmacological and non-pharmacological approaches. Results: The neuropathic pain working group agreed on prescribing antiepileptic drugs or antidepressants in the case of comorbidities with anxiety and depression. As a second choice, experts have agreed on the association of antiepileptics and antidepressants, while they disagree with the use of opioids. Medical cannabis and nutraceuticals are promising new treatment options, although more data is needed to prove their efficacy. The neurologists agreed in suggesting physical activity at the first visit, particularly aerobic and strength training. As a second choice, they considered a cognitive behavioral therapy approach to be useful. Conclusions: Pharmacologic treatment with antiepileptic drugs and antidepressants in patients with co-occurring anxiety and depression, as well as an early nonpharmacologic approach based primarily on physical activity, may be a useful indication in contemporary neurology clinical practice. Non-pharmacological options, such as cognitive behavioral therapy and non-invasive brain stimulation NIBS, could improve evidence of efficacy and lead to relevant improvement in FM-related disability. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.
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  Data: <searchLink fieldCode="AR" term="%22Devigili%2C+G%2E%22">Devigili, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di+Stefano%2C+G%2E%22">Di Stefano, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donadio%2C+V%2E%22">Donadio, V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frattale%2C+I%2E%22">Frattale, I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grazzi%2C+L%2E%22">Grazzi, L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mantovani%2C+E%2E%22">Mantovani, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nolano%2C+M%2E%22">Nolano, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Provitera%2C+V%2E%22">Provitera, V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quitadamo%2C+S%2E+G%2E%22">Quitadamo, S. G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tamburin%2C+S%2E%22">Tamburin, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Truini%2C+A%2E%22">Truini, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valeriani%2C+M%2E%22">Valeriani, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Furia%2C+A%2E%22">Furia, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vecchio%2C+E%2E%22">Vecchio, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fischetti%2C+F%2E%22">Fischetti, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greco%2C+G%2E%22">Greco, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Telesca%2C+A%2E%22">Telesca, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Tommaso%2C+M%2E%22">de Tommaso, M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2025, Vol. 46 Issue 5, p2263-2288. 26p.
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  Data: Background: Although fibromyalgia is a disabling disease, there is no targeted therapy for specific neurotransmitters or inflammatory mediators. Our aim was to provide neurologists with practical guidance for the management of these difficult patients based on a critical, narrative and non-systematic review of randomized controlled trials (RCTs) from the last 10 years. Methods: The members of the Special Interest Group Neuropathic Pain of the Italian Neurological Society evaluated the randomized controlled trials (RCTs) of the last 10 years and answered questions that allow a consensus on the main pharmacological and non-pharmacological approaches. Results: The neuropathic pain working group agreed on prescribing antiepileptic drugs or antidepressants in the case of comorbidities with anxiety and depression. As a second choice, experts have agreed on the association of antiepileptics and antidepressants, while they disagree with the use of opioids. Medical cannabis and nutraceuticals are promising new treatment options, although more data is needed to prove their efficacy. The neurologists agreed in suggesting physical activity at the first visit, particularly aerobic and strength training. As a second choice, they considered a cognitive behavioral therapy approach to be useful. Conclusions: Pharmacologic treatment with antiepileptic drugs and antidepressants in patients with co-occurring anxiety and depression, as well as an early nonpharmacologic approach based primarily on physical activity, may be a useful indication in contemporary neurology clinical practice. Non-pharmacological options, such as cognitive behavioral therapy and non-invasive brain stimulation NIBS, could improve evidence of efficacy and lead to relevant improvement in FM-related disability. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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