Reduction of rejection‐related emotions by transcranial direct current stimulation over right ventrolateral prefrontal cortex in borderline personality disorder: A double‐blind randomized pilot study.
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| Title: | Reduction of rejection‐related emotions by transcranial direct current stimulation over right ventrolateral prefrontal cortex in borderline personality disorder: A double‐blind randomized pilot study. |
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| Authors: | Lisco, Alessandro (AUTHOR), Gallucci, Alessia (AUTHOR), Fabietti, Chiara (AUTHOR), Fornaroli, Annalisa (AUTHOR), Marchesi, Carlo (AUTHOR), Preti, Emanuele (AUTHOR), Riva, Paolo (AUTHOR), De Panfilis, Chiara (AUTHOR), Romero Lauro, Leonor Josefina (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. May2025, Vol. 79 Issue 5, p239-247. 9p. |
| Subjects: | Borderline personality disorder, Transcranial direct current stimulation, Social marginality, Emotion regulation, Prefrontal cortex, Brain stimulation, Pilot projects, Rejection (Psychology) |
| Abstract: | Aims: Borderline personality disorder (BPD) patients show negative emotional reactions to both excluding and including social scenarios, with levels normalizing only during extreme inclusion. Prior research among healthy individuals highlights the right ventrolateral prefrontal cortex (rVLPFC) role in regulating emotional responses to social exclusion, since transcranial direct current stimulation (tDCS) of rVLPFC decreases rejection‐related emotions following social exclusion. This pilot study investigated whether, in BPD patients, tDCS over the rVLPFC reduces rejection‐related emotions not only after social exclusion but also after fair social inclusion. Methods: Forty BPD patients randomly received either real or sham tDCS on rVLPFC before participating in the Cyberball paradigm, which involved phases of inclusion, exclusion, and over‐inclusion. Participants self‐reported their level of rejection‐related emotions following each phase. Results: Transcranial direct current stimulation reduced rejection‐related emotions during both social exclusion and fair inclusion, but not during over‐inclusion. Specifically, those in the Real tDCS group exhibited comparable emotional responses to fair and over‐including scenarios, unlike those in the Sham group who experienced heightened rejection‐related emotions during fair inclusion compared to over‐inclusion. Conclusions: Transcranial direct current stimulation over the rVLPFC reduces BPD patients' tendency to feel rejected both in fairly including and excluding scenarios. These findings confirm the rVLPFC involvement in emotional regulation and highlight a therapeutic potential for tDCS in moderating BPD's typical heightened rejection‐related emotional responses to fairly including scenarios. This study supports the application of tDCS in BPD treatment, providing new insights into neuromodulatory interventions that can aid BPD patients to better regulate their emotions during varying social scenarios. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 184927082 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Reduction of rejection‐related emotions by transcranial direct current stimulation over right ventrolateral prefrontal cortex in borderline personality disorder: A double‐blind randomized pilot study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lisco%2C+Alessandro%22">Lisco, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gallucci%2C+Alessia%22">Gallucci, Alessia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fabietti%2C+Chiara%22">Fabietti, Chiara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fornaroli%2C+Annalisa%22">Fornaroli, Annalisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marchesi%2C+Carlo%22">Marchesi, Carlo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Preti%2C+Emanuele%22">Preti, Emanuele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riva%2C+Paolo%22">Riva, Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Panfilis%2C+Chiara%22">De Panfilis, Chiara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Romero+Lauro%2C+Leonor+Josefina%22">Romero Lauro, Leonor Josefina</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. May2025, Vol. 79 Issue 5, p239-247. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Borderline+personality+disorder%22">Borderline personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Transcranial+direct+current+stimulation%22">Transcranial direct current stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Social+marginality%22">Social marginality</searchLink><br /><searchLink fieldCode="DE" term="%22Emotion+regulation%22">Emotion regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stimulation%22">Brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Rejection+%28Psychology%29%22">Rejection (Psychology)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aims: Borderline personality disorder (BPD) patients show negative emotional reactions to both excluding and including social scenarios, with levels normalizing only during extreme inclusion. Prior research among healthy individuals highlights the right ventrolateral prefrontal cortex (rVLPFC) role in regulating emotional responses to social exclusion, since transcranial direct current stimulation (tDCS) of rVLPFC decreases rejection‐related emotions following social exclusion. This pilot study investigated whether, in BPD patients, tDCS over the rVLPFC reduces rejection‐related emotions not only after social exclusion but also after fair social inclusion. Methods: Forty BPD patients randomly received either real or sham tDCS on rVLPFC before participating in the Cyberball paradigm, which involved phases of inclusion, exclusion, and over‐inclusion. Participants self‐reported their level of rejection‐related emotions following each phase. Results: Transcranial direct current stimulation reduced rejection‐related emotions during both social exclusion and fair inclusion, but not during over‐inclusion. Specifically, those in the Real tDCS group exhibited comparable emotional responses to fair and over‐including scenarios, unlike those in the Sham group who experienced heightened rejection‐related emotions during fair inclusion compared to over‐inclusion. Conclusions: Transcranial direct current stimulation over the rVLPFC reduces BPD patients' tendency to feel rejected both in fairly including and excluding scenarios. These findings confirm the rVLPFC involvement in emotional regulation and highlight a therapeutic potential for tDCS in moderating BPD's typical heightened rejection‐related emotional responses to fairly including scenarios. This study supports the application of tDCS in BPD treatment, providing new insights into neuromodulatory interventions that can aid BPD patients to better regulate their emotions during varying social scenarios. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/pcn.13792 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 239 Subjects: – SubjectFull: Borderline personality disorder Type: general – SubjectFull: Transcranial direct current stimulation Type: general – SubjectFull: Social marginality Type: general – SubjectFull: Emotion regulation Type: general – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Brain stimulation Type: general – SubjectFull: Pilot projects Type: general – SubjectFull: Rejection (Psychology) Type: general Titles: – TitleFull: Reduction of rejection‐related emotions by transcranial direct current stimulation over right ventrolateral prefrontal cortex in borderline personality disorder: A double‐blind randomized pilot study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lisco, Alessandro – PersonEntity: Name: NameFull: Gallucci, Alessia – PersonEntity: Name: NameFull: Fabietti, Chiara – PersonEntity: Name: NameFull: Fornaroli, Annalisa – PersonEntity: Name: NameFull: Marchesi, Carlo – PersonEntity: Name: NameFull: Preti, Emanuele – PersonEntity: Name: NameFull: Riva, Paolo – PersonEntity: Name: NameFull: De Panfilis, Chiara – PersonEntity: Name: NameFull: Romero Lauro, Leonor Josefina IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 13231316 Numbering: – Type: volume Value: 79 – Type: issue Value: 5 Titles: – TitleFull: Psychiatry & Clinical Neurosciences Type: main |
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