Clozapine in the Spotlight: Understanding the Recent Clozapine REMS Changes and a Research Update for 2025.

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Bibliographic Details
Title: Clozapine in the Spotlight: Understanding the Recent Clozapine REMS Changes and a Research Update for 2025.
Authors: Mills, Jeremy, Long, Anna Catherine
Source: Issues in Mental Health Nursing. Jun2025, Vol. 46 Issue 6, p633-637. 5p.
Subjects: Psychiatry, Patient safety, Risk management in business, Antipsychotic agents, United States. Food & Drug Administration, Schizophrenia, Pharmacy information services, Drug approval, Clozapine, Neutropenia
Abstract: The article discusses the abrupt discontinuation of the Clozapine REMS safety program, which caused widespread disruption for clinicians and pharmacies managing treatment-resistant schizophrenia. Topics include the implications of REMS removal, ongoing blood monitoring requirements, and barriers to clozapine access, highlighting challenges faced by University of Tennessee College of Nursing and Peninsula Outpatient Pharmacy professionals in ensuring patient safety and medication continuity.
Database: Psychology and Behavioral Sciences Collection
Description
Abstract:The article discusses the abrupt discontinuation of the Clozapine REMS safety program, which caused widespread disruption for clinicians and pharmacies managing treatment-resistant schizophrenia. Topics include the implications of REMS removal, ongoing blood monitoring requirements, and barriers to clozapine access, highlighting challenges faced by University of Tennessee College of Nursing and Peninsula Outpatient Pharmacy professionals in ensuring patient safety and medication continuity.
ISSN:01612840
DOI:10.1080/01612840.2025.2503132