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Activation Likelihood Estimation Meta‐Analysis of the Effects of Cognitive Behavioral Therapy on Brain Activation in the Treatment of Depression and Anxiety Disorders.

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Title: Activation Likelihood Estimation Meta‐Analysis of the Effects of Cognitive Behavioral Therapy on Brain Activation in the Treatment of Depression and Anxiety Disorders.
Authors: Ren, Junjie (AUTHOR), Ma, Lijun (AUTHOR), Wu, Wanxin (AUTHOR), Qiu, Juan (AUTHOR), Zhang, Zhuo (AUTHOR), Hong, Yuxi (AUTHOR), Wang, Zushen (AUTHOR), Hou, Xinyu (AUTHOR), Jin, Jia (AUTHOR), Hu, Weixuan (AUTHOR), Wu, Yanran (AUTHOR), Chen, Xiaowei (AUTHOR), Luo, Jinyi (AUTHOR), Fan, Chuan (AUTHOR), Wang, Kai (AUTHOR), Li, Xiaoming (AUTHOR), Asif, Muhammad (AUTHOR)
Source: Depression & Anxiety (1091-4269). 6/17/2025, Vol. 2025, p1-12. 12p.
Subjects: Mental depression, Anxiety disorders, Psychotherapy, Neurobiology, Brain imaging, Brain stimulation, Cognitive therapy
Abstract: Background: Cognitive behavioral therapy (CBT) stands as a highly efficacious psychological treatment for both anxiety and depressive disorders. Nonetheless, scholarly debates persist regarding the specificities of brain area activation during CBT treatment for these disorders. Methodology: Utilizing activation likelihood estimation (ALE) analysis, this study aims to discern the neurobiological similarities and disparities between CBT's effects on anxiety and depressive disorders by examining functional brain areas. Results: A total of 22 articles, encompassing 443 patients, were included in the meta‐analysis. Our results show that in the resting state, patients with depression treated with CBT resulted in increased activation of the right and left ventral anterior cingulate cortex (vACC), left parahippocampal gyrus (PG), right subgyral, left inferior temporal gyrus (ITG), and right inferior occipital gyrus (IOG), whereas patients with anxiety disorders had increased activation of the right and left superior frontal gyrus (SFG) and decreased activation of the caudate after treatment. In the task state, increased activation of the right PG, right orbital frontal lobe, and right dorsal anterior cingulate cortex (dACC) was mainly observed after treatment in patients with anxiety disorders, and the left lentiform nucleus (LN), left dorsal entorhinal cortex, and right caudate activation were decreased. For depressive disorders, no consistent activation patterns emerged in the task state, likely due to limited studies or heterogeneity in task paradigms across included studies. Conclusion: CBT's efficacy relies on both shared (e.g., vACC‐mediated emotion regulation and cognitive control) and distinct neural mechanisms (fear‐circuit modulation in anxiety vs. memory‐network enhancement in depression), informing biomarker‐driven treatment personalization. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Activation Likelihood Estimation Meta‐Analysis of the Effects of Cognitive Behavioral Therapy on Brain Activation in the Treatment of Depression and Anxiety Disorders.
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  Data: <searchLink fieldCode="AR" term="%22Ren%2C+Junjie%22">Ren, Junjie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Lijun%22">Ma, Lijun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Wanxin%22">Wu, Wanxin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qiu%2C+Juan%22">Qiu, Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zhuo%22">Zhang, Zhuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hong%2C+Yuxi%22">Hong, Yuxi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Zushen%22">Wang, Zushen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hou%2C+Xinyu%22">Hou, Xinyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jin%2C+Jia%22">Jin, Jia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Weixuan%22">Hu, Weixuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Yanran%22">Wu, Yanran</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Xiaowei%22">Chen, Xiaowei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Jinyi%22">Luo, Jinyi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fan%2C+Chuan%22">Fan, Chuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Kai%22">Wang, Kai</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Xiaoming%22">Li, Xiaoming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asif%2C+Muhammad%22">Asif, Muhammad</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 6/17/2025, Vol. 2025, p1-12. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobiology%22">Neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stimulation%22">Brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Cognitive behavioral therapy (CBT) stands as a highly efficacious psychological treatment for both anxiety and depressive disorders. Nonetheless, scholarly debates persist regarding the specificities of brain area activation during CBT treatment for these disorders. Methodology: Utilizing activation likelihood estimation (ALE) analysis, this study aims to discern the neurobiological similarities and disparities between CBT's effects on anxiety and depressive disorders by examining functional brain areas. Results: A total of 22 articles, encompassing 443 patients, were included in the meta‐analysis. Our results show that in the resting state, patients with depression treated with CBT resulted in increased activation of the right and left ventral anterior cingulate cortex (vACC), left parahippocampal gyrus (PG), right subgyral, left inferior temporal gyrus (ITG), and right inferior occipital gyrus (IOG), whereas patients with anxiety disorders had increased activation of the right and left superior frontal gyrus (SFG) and decreased activation of the caudate after treatment. In the task state, increased activation of the right PG, right orbital frontal lobe, and right dorsal anterior cingulate cortex (dACC) was mainly observed after treatment in patients with anxiety disorders, and the left lentiform nucleus (LN), left dorsal entorhinal cortex, and right caudate activation were decreased. For depressive disorders, no consistent activation patterns emerged in the task state, likely due to limited studies or heterogeneity in task paradigms across included studies. Conclusion: CBT's efficacy relies on both shared (e.g., vACC‐mediated emotion regulation and cognitive control) and distinct neural mechanisms (fear‐circuit modulation in anxiety vs. memory‐network enhancement in depression), informing biomarker‐driven treatment personalization. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1155/da/3557367
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      – Code: eng
        Text: English
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      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Anxiety disorders
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      – SubjectFull: Psychotherapy
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      – SubjectFull: Neurobiology
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      – SubjectFull: Brain imaging
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      – SubjectFull: Brain stimulation
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      – SubjectFull: Cognitive therapy
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      – TitleFull: Activation Likelihood Estimation Meta‐Analysis of the Effects of Cognitive Behavioral Therapy on Brain Activation in the Treatment of Depression and Anxiety Disorders.
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