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Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.

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Title: Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.
Authors: Bouliane, Mélanie, Boivin, Michel, Kretschmer, Tina, Lafreniere, Bianca, Paquin, Stéphane, Tremblay, Richard, Côté, Sylvana, Gouin, Jean-Philippe, Andlauer, Till F. M., Petitclerc, Amélie, Ouellet-Morin, Isabelle
Source: European Child & Adolescent Psychiatry. Aug2025, Vol. 34 Issue 8, p2443-2451. 9p.
Subjects: Risk factors of attention-deficit hyperactivity disorder, Aggression (Psychology), Longitudinal method, Externalizing behavior, Factor analysis, Hyperkinesia, Adverse childhood experiences, Genotypes, Oppositional defiant disorder in children, Adolescence, Children
Geographic Terms: Québec (Province)
Abstract: Individual differences in physical aggression (PA) are largely heritable. However, it remains unclear how genetic propensity for aggression manifests early in life and relates to school-age PA. Preschool externalizing behavior problems (EXT) and adverse experiences are known predictors of school-age PA and also partly heritable. We investigated whether early childhood EXT and adverse experiences mediated the association between polygenic scores and school-age PA. Genotype data collected from 721 participants in the Quebec Longitudinal Study of Child Development (45% males) were used to derive polygenic scores for aggression (PGSAGG) and attention deficit/hyperactivity disorder (PGSADHD). PA was reported annually or biennially on six occasions between ages 6 and 13 by distinct teachers. Mothers reported EXT (PA, hyperactivity, opposition) and adverse experiences (peer difficulties and harsh parenting) on three occasions between ages 3½ and 5. Both PGSs proved significant predictors of school-age PA. However, no early behaviors or adverse experiences mediated the association between PGSAGG and school-age PA. Contrastingly, hyperactivity and opposition each partially mediated the association between PGSADHD and school-age PA. Notably, when both mediators were included in the same model, only hyperactivity remained significant. This study contributes to identifying early manifestations of genetic risk for PA, which may serve as early targets for intervention. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Aug2025, Vol. 34 Issue 8, p2443-2451. 9p.
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  Data: Individual differences in physical aggression (PA) are largely heritable. However, it remains unclear how genetic propensity for aggression manifests early in life and relates to school-age PA. Preschool externalizing behavior problems (EXT) and adverse experiences are known predictors of school-age PA and also partly heritable. We investigated whether early childhood EXT and adverse experiences mediated the association between polygenic scores and school-age PA. Genotype data collected from 721 participants in the Quebec Longitudinal Study of Child Development (45% males) were used to derive polygenic scores for aggression (PGSAGG) and attention deficit/hyperactivity disorder (PGSADHD). PA was reported annually or biennially on six occasions between ages 6 and 13 by distinct teachers. Mothers reported EXT (PA, hyperactivity, opposition) and adverse experiences (peer difficulties and harsh parenting) on three occasions between ages 3½ and 5. Both PGSs proved significant predictors of school-age PA. However, no early behaviors or adverse experiences mediated the association between PGSAGG and school-age PA. Contrastingly, hyperactivity and opposition each partially mediated the association between PGSADHD and school-age PA. Notably, when both mediators were included in the same model, only hyperactivity remained significant. This study contributes to identifying early manifestations of genetic risk for PA, which may serve as early targets for intervention. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00787-025-02654-4
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        Text: English
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      – SubjectFull: Aggression (Psychology)
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      – SubjectFull: Externalizing behavior
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