The association between cannabis use and suicidal intensity in psychiatric inpatients.

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Title: The association between cannabis use and suicidal intensity in psychiatric inpatients.
Authors: Oladunjoye, Adeolu Funso (AUTHOR), Swann, Alan (AUTHOR), Kosten, Thomas R. (AUTHOR), Patriquin, Michelle (AUTHOR), Bigdeli, Tim (AUTHOR), Barr, Peter (AUTHOR), Wilkinson, Anna V. (AUTHOR), Harding, Mark J. (AUTHOR), Nielsen, David A. (AUTHOR), Graham, David P. (AUTHOR)
Source: American Journal on Addictions. Sep2025, Vol. 34 Issue 5, p506-516. 11p.
Subjects: Suicidal ideation, Marijuana abuse, Substance abuse, Gender differences (Sociology), Mental health, Adults, Cognitive flexibility, People with mental illness
Abstract: Background: Over the past 15 years, most states have legalized the medical use of cannabis. Since then, daily use nearly tripled while the number of adults dying by suicide increased by 31%. Key studies found a greater suicidal intensity associated with cannabis use (CU) in adolescents. Adult associations have been understudied. The purpose of this study was to evaluate associations between CU and suicidal ideation intensity (SII) in adults. Methods: We examined 530 psychiatric inpatients ages 18 and above using the Columbia‐Suicide Severity Rating Scale and the Alcohol, Smoking and Substance Involvement Screening Test for CU. We conducted a path analysis model of moderating and mediating factors, including psychiatric comorbidity, emotional regulation, psychological flexibility, and polygenic risk scores for externalization, CU, and suicide. Results: Sixteen percent of the participants had no suicidality, 34.3% reported suicidal ideation, and 49.6% reported a prior suicide attempt. CU was found to be associated with lower risk of SII for females (p =.026) but not for males (p =.525), and increased CU was associated with greater risk of SII with lower psychological flexibility in males (p =.049) but not females (p =.628). Conclusions: CU was associated with increased SII among psychiatric inpatients, with sex‐specific patterns and potential mediation by psychological flexibility. Further studies exploring specific amounts, duration of use, and time frames of CU during adolescence and adulthood may provide insights into its associated risks, especially as legalization expands. Scientific significance: Patterns of past and current CU may increase understanding of mechanisms predicting increased SII in adult male psychiatric inpatients. [ABSTRACT FROM AUTHOR]
Copyright of American Journal on Addictions is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The association between cannabis use and suicidal intensity in psychiatric inpatients.
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  Data: <searchLink fieldCode="AR" term="%22Oladunjoye%2C+Adeolu+Funso%22">Oladunjoye, Adeolu Funso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Swann%2C+Alan%22">Swann, Alan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kosten%2C+Thomas+R%2E%22">Kosten, Thomas R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patriquin%2C+Michelle%22">Patriquin, Michelle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bigdeli%2C+Tim%22">Bigdeli, Tim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barr%2C+Peter%22">Barr, Peter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilkinson%2C+Anna+V%2E%22">Wilkinson, Anna V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harding%2C+Mark+J%2E%22">Harding, Mark J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nielsen%2C+David+A%2E%22">Nielsen, David A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Graham%2C+David+P%2E%22">Graham, David P.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+on+Addictions%22">American Journal on Addictions</searchLink>. Sep2025, Vol. 34 Issue 5, p506-516. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Suicidal+ideation%22">Suicidal ideation</searchLink><br /><searchLink fieldCode="DE" term="%22Marijuana+abuse%22">Marijuana abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+differences+%28Sociology%29%22">Gender differences (Sociology)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+flexibility%22">Cognitive flexibility</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+mental+illness%22">People with mental illness</searchLink>
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  Label: Abstract
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  Data: Background: Over the past 15 years, most states have legalized the medical use of cannabis. Since then, daily use nearly tripled while the number of adults dying by suicide increased by 31%. Key studies found a greater suicidal intensity associated with cannabis use (CU) in adolescents. Adult associations have been understudied. The purpose of this study was to evaluate associations between CU and suicidal ideation intensity (SII) in adults. Methods: We examined 530 psychiatric inpatients ages 18 and above using the Columbia‐Suicide Severity Rating Scale and the Alcohol, Smoking and Substance Involvement Screening Test for CU. We conducted a path analysis model of moderating and mediating factors, including psychiatric comorbidity, emotional regulation, psychological flexibility, and polygenic risk scores for externalization, CU, and suicide. Results: Sixteen percent of the participants had no suicidality, 34.3% reported suicidal ideation, and 49.6% reported a prior suicide attempt. CU was found to be associated with lower risk of SII for females (p =.026) but not for males (p =.525), and increased CU was associated with greater risk of SII with lower psychological flexibility in males (p =.049) but not females (p =.628). Conclusions: CU was associated with increased SII among psychiatric inpatients, with sex‐specific patterns and potential mediation by psychological flexibility. Further studies exploring specific amounts, duration of use, and time frames of CU during adolescence and adulthood may provide insights into its associated risks, especially as legalization expands. Scientific significance: Patterns of past and current CU may increase understanding of mechanisms predicting increased SII in adult male psychiatric inpatients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of American Journal on Addictions is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ajad.70047
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        Text: English
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      – SubjectFull: Suicidal ideation
        Type: general
      – SubjectFull: Marijuana abuse
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      – SubjectFull: Substance abuse
        Type: general
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      – SubjectFull: Cognitive flexibility
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      – SubjectFull: People with mental illness
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      – TitleFull: The association between cannabis use and suicidal intensity in psychiatric inpatients.
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              Text: Sep2025
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