Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review.
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| Title: | Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review. |
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| Authors: | Ghazali, Siti Nur Akmal (AUTHOR), Manan, Hanani Abdul (AUTHOR), Chan, Caryn Mei Hsien (AUTHOR), Eezamuddeen, Marfu'ah Nik (AUTHOR), Yahya, Noorazrul (AUTHOR) |
| Source: | Quality of Life Research. Sep2025, Vol. 34 Issue 9, p2531-2546. 16p. |
| Subjects: | Head & neck cancer, Overall survival, Health outcome assessment, Radiotherapy, Survival analysis (Biometry), Quality of life, Physical mobility |
| Abstract: | Purpose: The association between health-related quality of life (HQoL) and overall survival (OS) among head and neck cancer (HNC) patients remains an important yet complex topic. This study aims to comprehensively analyze the prognostic effects of HQoL indices and symptoms-specific outcomes on overall survival in HNC patients. Methods: A systematic literature search was conducted in PubMed, Web of Science and Scopus databases. The QUIPS tool was used to assess the risk of bias in the prognostic studies. The variables from the HQoL assessments included as predictors of OS were recorded. Different phases of measurements either pre or post-treatment (3 to > 12 months after completion) were also classified to observe the patterns. This review utilized a proposed best-evidence synthesis in which the consistency of significant results from multivariate analysis was observed. Each index that shows > 75% proportion of high-quality studies with same result is classified as strong evidence. Results: Following an extensive search yielding 440 articles, the rigorous screening process identified 32 studies involving 12,206 HNC patients. This review underscores the pivotal role of higher post-treatment physical functioning predicting OS, which is supported by strong evidence and consistent findings. Three indices showed moderate evidence which are pretreatment physical function, post-treatment general HQoL and post-treatment social function. Notably, the analysis revealed that specific general-cancer symptoms, including appetite loss and dyspnea, were reported in association with OS in seven out of 33 instances, following multivariate analysis. Furthermore, the study highlighted the significance of social eating and problems with swallowing as predictors of OS (≥ 5 times instances) compared to other HNC symptoms-specific outcomes. Conclusion: This study sheds light on the underexplored role of post-treatment physical function as predictors for OS, complementing the well-discussed pretreatment physical function. It identifies four specific symptoms significantly impacting OS, highlighting the need for effective management strategies. [ABSTRACT FROM AUTHOR] |
| Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 187972847 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ghazali%2C+Siti+Nur+Akmal%22">Ghazali, Siti Nur Akmal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manan%2C+Hanani+Abdul%22">Manan, Hanani Abdul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Caryn+Mei+Hsien%22">Chan, Caryn Mei Hsien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eezamuddeen%2C+Marfu'ah+Nik%22">Eezamuddeen, Marfu'ah Nik</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yahya%2C+Noorazrul%22">Yahya, Noorazrul</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Sep2025, Vol. 34 Issue 9, p2531-2546. 16p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Head+%26+neck+cancer%22">Head & neck cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Overall+survival%22">Overall survival</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Survival+analysis+%28Biometry%29%22">Survival analysis (Biometry)</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+mobility%22">Physical mobility</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: The association between health-related quality of life (HQoL) and overall survival (OS) among head and neck cancer (HNC) patients remains an important yet complex topic. This study aims to comprehensively analyze the prognostic effects of HQoL indices and symptoms-specific outcomes on overall survival in HNC patients. Methods: A systematic literature search was conducted in PubMed, Web of Science and Scopus databases. The QUIPS tool was used to assess the risk of bias in the prognostic studies. The variables from the HQoL assessments included as predictors of OS were recorded. Different phases of measurements either pre or post-treatment (3 to > 12 months after completion) were also classified to observe the patterns. This review utilized a proposed best-evidence synthesis in which the consistency of significant results from multivariate analysis was observed. Each index that shows > 75% proportion of high-quality studies with same result is classified as strong evidence. Results: Following an extensive search yielding 440 articles, the rigorous screening process identified 32 studies involving 12,206 HNC patients. This review underscores the pivotal role of higher post-treatment physical functioning predicting OS, which is supported by strong evidence and consistent findings. Three indices showed moderate evidence which are pretreatment physical function, post-treatment general HQoL and post-treatment social function. Notably, the analysis revealed that specific general-cancer symptoms, including appetite loss and dyspnea, were reported in association with OS in seven out of 33 instances, following multivariate analysis. Furthermore, the study highlighted the significance of social eating and problems with swallowing as predictors of OS (≥ 5 times instances) compared to other HNC symptoms-specific outcomes. Conclusion: This study sheds light on the underexplored role of post-treatment physical function as predictors for OS, complementing the well-discussed pretreatment physical function. It identifies four specific symptoms significantly impacting OS, highlighting the need for effective management strategies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11136-025-03933-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 16 StartPage: 2531 Subjects: – SubjectFull: Head & neck cancer Type: general – SubjectFull: Overall survival Type: general – SubjectFull: Health outcome assessment Type: general – SubjectFull: Radiotherapy Type: general – SubjectFull: Survival analysis (Biometry) Type: general – SubjectFull: Quality of life Type: general – SubjectFull: Physical mobility Type: general Titles: – TitleFull: Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ghazali, Siti Nur Akmal – PersonEntity: Name: NameFull: Manan, Hanani Abdul – PersonEntity: Name: NameFull: Chan, Caryn Mei Hsien – PersonEntity: Name: NameFull: Eezamuddeen, Marfu'ah Nik – PersonEntity: Name: NameFull: Yahya, Noorazrul IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09629343 Numbering: – Type: volume Value: 34 – Type: issue Value: 9 Titles: – TitleFull: Quality of Life Research Type: main |
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