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Parental Inflammatory Bowel Disease with Child Autism: A Comprehensive Review and Meta-Analysis.

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Title: Parental Inflammatory Bowel Disease with Child Autism: A Comprehensive Review and Meta-Analysis.
Authors: Wang, Xingmu (AUTHOR), Qian, Chenfei (AUTHOR), Yao, Huanying (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Oct2025, Vol. 55 Issue 10, p3662-3669. 8p.
Subjects: Autism risk factors, Risk assessment, Medical information storage & retrieval systems, CINAHL database, Meta-analysis, Descriptive statistics, Relative medical risk, Inflammatory bowel diseases, Systematic reviews, MEDLINE, Medical databases, Psychology of parents, Asperger's syndrome, Online information services, Confidence intervals, Psychology information storage & retrieval systems, Publication bias, Intergenerational relations, Children
Abstract: Inflammatory bowel disease (IBD) has been shown to be connected to a greater possibility of neurologically developed problems, such as autism spectrum disorders (ASDs). However, the proof linking parental IBD with ASD in offspring is inconclusive. Thus, we carried out a meta-analysis and comprehensive review to elucidate such linking. Prior research was identified through reviewing multiple internet-based sources, including Cochrane, Web of Knowledge, Embase, CINAHL, PubMed, and PsycINFO, from 1960 to December 2022. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were determined employing random-effects models, in spite of the I2 statistic measurement of heterogeneity. Prediction intervals (PIs) have been presented to allow for more useful inferences and to indicate the range of genuine effects that might be predicted in future scenarios. Six studies (two case-control studies and four cohort studies) involving 3,200,199 participants were incorporated into the meta-analysis. The pooled RRs of ASDs among offspring of IBD parents were 1.15 (95% CI, 0.92 to 1.45, P = 0.226; I2 = 81.4%, P = 0.003; PI, 0.53–2.62), indicating no significant connection between parental IBD and the likelihood of ASDs in children. Type of IBD, and sex both also yielded no statistically significant results according to subgroup analysis. Our meta-analysis does not provide evidence that parental IBD is connected with the elevated likelihood of ASDs in their children. To confirm these results and understand their underlying mechanisms, additional research with larger sample sizes and improved study designs is required. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Parental Inflammatory Bowel Disease with Child Autism: A Comprehensive Review and Meta-Analysis.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Oct2025, Vol. 55 Issue 10, p3662-3669. 8p.
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  Data: Inflammatory bowel disease (IBD) has been shown to be connected to a greater possibility of neurologically developed problems, such as autism spectrum disorders (ASDs). However, the proof linking parental IBD with ASD in offspring is inconclusive. Thus, we carried out a meta-analysis and comprehensive review to elucidate such linking. Prior research was identified through reviewing multiple internet-based sources, including Cochrane, Web of Knowledge, Embase, CINAHL, PubMed, and PsycINFO, from 1960 to December 2022. Pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were determined employing random-effects models, in spite of the I2 statistic measurement of heterogeneity. Prediction intervals (PIs) have been presented to allow for more useful inferences and to indicate the range of genuine effects that might be predicted in future scenarios. Six studies (two case-control studies and four cohort studies) involving 3,200,199 participants were incorporated into the meta-analysis. The pooled RRs of ASDs among offspring of IBD parents were 1.15 (95% CI, 0.92 to 1.45, P = 0.226; I2 = 81.4%, P = 0.003; PI, 0.53–2.62), indicating no significant connection between parental IBD and the likelihood of ASDs in children. Type of IBD, and sex both also yielded no statistically significant results according to subgroup analysis. Our meta-analysis does not provide evidence that parental IBD is connected with the elevated likelihood of ASDs in their children. To confirm these results and understand their underlying mechanisms, additional research with larger sample sizes and improved study designs is required. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10803-024-06458-4
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 3662
    Subjects:
      – SubjectFull: Autism risk factors
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Medical information storage & retrieval systems
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      – SubjectFull: CINAHL database
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Relative medical risk
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      – SubjectFull: Inflammatory bowel diseases
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      – SubjectFull: Intergenerational relations
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      – SubjectFull: Children
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    Titles:
      – TitleFull: Parental Inflammatory Bowel Disease with Child Autism: A Comprehensive Review and Meta-Analysis.
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            NameFull: Wang, Xingmu
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              Text: Oct2025
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