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2-Hydroxychalcone attenuates airway inflammation, oxidative stress, and NF-κB activation in ovalbumin-induced asthma model.

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Title: 2-Hydroxychalcone attenuates airway inflammation, oxidative stress, and NF-κB activation in ovalbumin-induced asthma model.
Authors: Abdelmawgood, Islam Ahmed (AUTHOR), Kotb, Mohamed A. (AUTHOR), Waleed Ebeed, Bassam (AUTHOR), Samy Hassan Eltras, Hassan (AUTHOR), Mahmoud Badr, Abeer (AUTHOR), Mahana, Noha A. (AUTHOR), Saber Mohamed, Ayman (AUTHOR), Goda, Lamiaa (AUTHOR), Lotfy Khalaf, Marina (AUTHOR), Sayed, Ahmed M. (AUTHOR), Zahran, Rawan G. (AUTHOR), Abdelazeem, Menna S. (AUTHOR), Eltaweel, Seif H. (AUTHOR), Ali Ramadan, Sohaib (AUTHOR), Sharaf, Bahaa (AUTHOR), Adel, Abdulrahman (AUTHOR), Ashry, Hamid (AUTHOR), Hesham Abdelfattah, Hadeer (AUTHOR)
Source: Journal of Asthma. Nov2025, Vol. 62 Issue 11, p1880-1892. 13p.
Subjects: Asthma, Oxidative stress, Flavonoids, NF-kappa B, Ovalbumins, Bronchitis, Anti-inflammatory agents, Antioxidants
Abstract: Background: Asthma is a pulmonary disorder marked by limited lung function and a noticeable infiltrate of inflammatory cells. Chalcones are commonly found in food plants and are regarded as precursors of flavonoids. Moreover, they can also be synthesized by chemical processes in controlled laboratory conditions. 2-Hydroxychalcone (2HC) has been associated with several biological functions, such as antioxidant, anti-inflammatory, antidiabetic, and anticancer properties. However, we have yet to study its potential for treating asthma. This study aimed to investigate the inhibitory effects of 2HC on allergic asthma. Methods: We established a mouse model of asthma by subjecting BALB/c mice to ovalbumin (OVA) exposure and sensitization. We conducted a study to examine the impact of 2HC on airway inflammation, the infiltration of inflammatory cells, oxidative stress, excessive mucus production, immunoglobulin E (IgE) levels, and the production of IL-4 and IL-1β. In addition, NF-κB expression was quantified using ELISA and immunohistochemistry (IHC). Results: The administration of 2HC resulted in a considerable reduction in lung oxidative stress, infiltration of inflammatory cells, levels of IgE, IL-4, and IL-1β, production of mucus, and activation of NF-κB. Conclusion: Our findings showed that 2HC is anti-inflammatory and antioxidant, suggesting that it may be useful in treating asthma by blocking NF-κB activation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Data: 2-Hydroxychalcone attenuates airway inflammation, oxidative stress, and NF-κB activation in ovalbumin-induced asthma model.
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  Data: <searchLink fieldCode="AR" term="%22Abdelmawgood%2C+Islam+Ahmed%22">Abdelmawgood, Islam Ahmed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kotb%2C+Mohamed+A%2E%22">Kotb, Mohamed A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Waleed+Ebeed%2C+Bassam%22">Waleed Ebeed, Bassam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Samy+Hassan+Eltras%2C+Hassan%22">Samy Hassan Eltras, Hassan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahmoud+Badr%2C+Abeer%22">Mahmoud Badr, Abeer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahana%2C+Noha+A%2E%22">Mahana, Noha A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saber+Mohamed%2C+Ayman%22">Saber Mohamed, Ayman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goda%2C+Lamiaa%22">Goda, Lamiaa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lotfy+Khalaf%2C+Marina%22">Lotfy Khalaf, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sayed%2C+Ahmed+M%2E%22">Sayed, Ahmed M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zahran%2C+Rawan+G%2E%22">Zahran, Rawan G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdelazeem%2C+Menna+S%2E%22">Abdelazeem, Menna S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eltaweel%2C+Seif+H%2E%22">Eltaweel, Seif H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali+Ramadan%2C+Sohaib%22">Ali Ramadan, Sohaib</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharaf%2C+Bahaa%22">Sharaf, Bahaa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adel%2C+Abdulrahman%22">Adel, Abdulrahman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ashry%2C+Hamid%22">Ashry, Hamid</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hesham+Abdelfattah%2C+Hadeer%22">Hesham Abdelfattah, Hadeer</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Nov2025, Vol. 62 Issue 11, p1880-1892. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Flavonoids%22">Flavonoids</searchLink><br /><searchLink fieldCode="DE" term="%22NF-kappa+B%22">NF-kappa B</searchLink><br /><searchLink fieldCode="DE" term="%22Ovalbumins%22">Ovalbumins</searchLink><br /><searchLink fieldCode="DE" term="%22Bronchitis%22">Bronchitis</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Asthma is a pulmonary disorder marked by limited lung function and a noticeable infiltrate of inflammatory cells. Chalcones are commonly found in food plants and are regarded as precursors of flavonoids. Moreover, they can also be synthesized by chemical processes in controlled laboratory conditions. 2-Hydroxychalcone (2HC) has been associated with several biological functions, such as antioxidant, anti-inflammatory, antidiabetic, and anticancer properties. However, we have yet to study its potential for treating asthma. This study aimed to investigate the inhibitory effects of 2HC on allergic asthma. Methods: We established a mouse model of asthma by subjecting BALB/c mice to ovalbumin (OVA) exposure and sensitization. We conducted a study to examine the impact of 2HC on airway inflammation, the infiltration of inflammatory cells, oxidative stress, excessive mucus production, immunoglobulin E (IgE) levels, and the production of IL-4 and IL-1β. In addition, NF-κB expression was quantified using ELISA and immunohistochemistry (IHC). Results: The administration of 2HC resulted in a considerable reduction in lung oxidative stress, infiltration of inflammatory cells, levels of IgE, IL-4, and IL-1β, production of mucus, and activation of NF-κB. Conclusion: Our findings showed that 2HC is anti-inflammatory and antioxidant, suggesting that it may be useful in treating asthma by blocking NF-κB activation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/02770903.2025.2526384
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      – Code: eng
        Text: English
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        PageCount: 13
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        Type: general
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      – SubjectFull: Anti-inflammatory agents
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