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Estrogen and Estrogen Receptors in Cardioimmunology: Implications in Physiology, Pathophysiology, and Therapeutic Strategies.

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Title: Estrogen and Estrogen Receptors in Cardioimmunology: Implications in Physiology, Pathophysiology, and Therapeutic Strategies.
Authors: Hou, Hongjian (AUTHOR), Adzika, Gabriel K. (AUTHOR)
Source: Acta Physiologica. Dec2025, Vol. 241 Issue 12, p1-19. 19p.
Subjects: Estrogen, Estrogen receptors, Cardiovascular diseases, Inflammation, Therapeutics, Immunoregulation, Cardiovascular agents
Abstract: Estrogen (E2) and estrogen receptors (ERs) play vital roles in conferring cardioprotection by modulating several immunological homeostatic responses in cardiovascular tissues. Over the recent decades, the role of inflammatory responses as a tangential component impacting cardiac function and disease are being appreciated and investigated to elucidate the underlying pathomechanisms, identify and develop therapeutic strategies; thus, the emergence of the multi‐disciplinary field—cardioimmunology. Here, after summarizing expressions and functionalities of ERs in cellular constituents of the cardiovascular system, we discuss synergistic estrogenic signaling mechanisms preserving cardiovascular function and immune homeostasis. Next, we review studies implicating E2 and ERs in inflammation‐driven cardiovascular disease initiation and progression and highlight therapeutic strategies and clinical implications to foster further research into promoting cardiovascular health. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Estrogen and Estrogen Receptors in Cardioimmunology: Implications in Physiology, Pathophysiology, and Therapeutic Strategies.
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  Data: <searchLink fieldCode="AR" term="%22Hou%2C+Hongjian%22">Hou, Hongjian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adzika%2C+Gabriel+K%2E%22">Adzika, Gabriel K.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Dec2025, Vol. 241 Issue 12, p1-19. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Estrogen%22">Estrogen</searchLink><br /><searchLink fieldCode="DE" term="%22Estrogen+receptors%22">Estrogen receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases%22">Cardiovascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+agents%22">Cardiovascular agents</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Estrogen (E2) and estrogen receptors (ERs) play vital roles in conferring cardioprotection by modulating several immunological homeostatic responses in cardiovascular tissues. Over the recent decades, the role of inflammatory responses as a tangential component impacting cardiac function and disease are being appreciated and investigated to elucidate the underlying pathomechanisms, identify and develop therapeutic strategies; thus, the emergence of the multi‐disciplinary field—cardioimmunology. Here, after summarizing expressions and functionalities of ERs in cellular constituents of the cardiovascular system, we discuss synergistic estrogenic signaling mechanisms preserving cardiovascular function and immune homeostasis. Next, we review studies implicating E2 and ERs in inflammation‐driven cardiovascular disease initiation and progression and highlight therapeutic strategies and clinical implications to foster further research into promoting cardiovascular health. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/apha.70124
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      – Code: eng
        Text: English
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        PageCount: 19
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    Subjects:
      – SubjectFull: Estrogen
        Type: general
      – SubjectFull: Estrogen receptors
        Type: general
      – SubjectFull: Cardiovascular diseases
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Immunoregulation
        Type: general
      – SubjectFull: Cardiovascular agents
        Type: general
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      – TitleFull: Estrogen and Estrogen Receptors in Cardioimmunology: Implications in Physiology, Pathophysiology, and Therapeutic Strategies.
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              M: 12
              Text: Dec2025
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              Y: 2025
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